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Overview on Biological Activities of Imidazole Derivatives

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Nanostructured Biomaterials

Part of the book series: Materials Horizons: From Nature to Nanomaterials ((MHFNN))

Abstract

Imidazole and its derivatives are one of the most important and widely used heterocycles in medicinal chemistry, natural products, and synthetic chemicals. Because of the imidazole ring's unique structural features, imidazole derivatives may easily attach to a wide range of enzymes and receptors via a number of weak interactions, demonstrating a wide range of biological and pharmacological effects. Several imidazole derivatives have been widely used in the clinic to treat a wide range of illnesses, suggesting their enormous potential for further research. In the realm of medicinal chemistry, this chapter presents a comprehensive summary of current findings in imidazole derivatives as anti-inflammatory, anticancer, antiviral, antibacterial, and other therapeutic agents.

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Abbreviations

U.S. FDA:

United States Food and Drug Administration

ZE:

Zollinger-Ellison syndrome

ARB:

Angiotensin II receptor blocker

DNA:

Deoxyribonucleic Acid

CNS:

Central Nervous System

ACE:

Angiotensin-converting enzyme

GABA:

Gamma-Aminobutyric Acid

NSAID:

Non-steroidal Anti-inflammatory Drugs

MTIC:

3-Methyl-(triazen-1-yl)imidazole-4-carboxamide

TIMP:

Thioinosine monophosphate

HER2:

Human Epidermal Growth Factor Receptor 2

RNA:

Ribonucleic Acid

HCV:

Hepatitis C Virus

IBS-D:

Irritable Bowel Syndrome with Diarrhoea

CYP3A:

Cytochrome P450 3A

ara-GTP:

Ara-G triphosphate

GERD:

Gastroesophageal Reflux Disease

DPP-4:

Dipeptidyl peptidase-4

GLP-1:

Glucagon-like peptide 1

GIP:

Gastric inhibitory polypeptide

TK:

Thymidine kinase

NS5A:

Nonstructural protein 5A

XMP:

Xanthosine monophosphate

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Authors and Affiliations

  1. Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal, Manipur, 795004, India

    Raghuram Gujjarappa, Arup K. Kabi, Nagaraju Vodnala, Ujjawal Tyagi, Dhananjaya Kaldhi & Chandi C. Malakar

  2. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Chunilal Bhawan, 168, Maniktala Main Road, KolkataKolkata, 70005, India

    Sattu Sravani, Aakriti Garg, Ravichandiran Velayutham & Sreya Gupta

  3. Department of Chemistry, Central University of Punjab, Bathinda, Punjab, 151001, India

    Virender Singh

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  1. Raghuram Gujjarappa
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Correspondence to Chandi C. Malakar .

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  1. Department of Physics, National Institute of Technology Manipur, Imphal, India

    Bibhu Prasad Swain

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Gujjarappa, R. et al. (2022). Overview on Biological Activities of Imidazole Derivatives. In: Swain, B.P. (eds) Nanostructured Biomaterials. Materials Horizons: From Nature to Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-16-8399-2_6

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