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Development of αβ T Cells with Innate Functions

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Innate Lymphoid Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1365))

Abstract

Although we mostly think of αβ T cells as components of the adaptive immune system, a number of them differentiate into alternative lineages. These lineages express TCRs with limited diversity, and functionally bridge the gap between innate and adaptive immunity. They tend to be tissue resident, and mount potent cytokine responses very rapidly after activation, and their development and functional maturation are strongly influenced by the microbiome. Here, we compare the development pathways and interactions with the microbiome of natural killer T (NKT) cells and mucosal-associated invariant T (MAIT cells), the two best studied “innate-like” αβ T cell populations.

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Acknowledgements

J.A.I. is funded by NIH R01 AI129458.

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Authors and Affiliations

  1. Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, OK, USA

    José Alberola-Ila

  2. Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA

    José Alberola-Ila

  3. Department of Cell Biology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA

    José Alberola-Ila

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  1. José Alberola-Ila
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Correspondence to José Alberola-Ila .

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  1. Program in Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

    Xiao-Hong Sun

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Alberola-Ila, J. (2022). Development of αβ T Cells with Innate Functions. In: Sun, XH. (eds) Innate Lymphoid Cells. Advances in Experimental Medicine and Biology, vol 1365. Springer, Singapore. https://doi.org/10.1007/978-981-16-8387-9_10

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