Skip to main content

Removal of Pharmaceutical Compounds: Overview of Treatment Methods

  • Chapter
  • First Online:
New Trends in Emerging Environmental Contaminants

Part of the book series: Energy, Environment, and Sustainability ((ENENSU))

Abstract

As human lifestyle is improved over the years due to technological, medical and many more developments but in the same time, it has also increased new environment and health challenges. The Emerging contaminants (ECs) are uncontrolled disposal of pollutants, they include group of synthetic chemicals in worldwide use such as water disinfection by-products, pharmaceuticals, chemical fertilizers, pesticides, gasoline additives, and man-made nanomaterials, etc. Pharmaceutical compounds (PCs) are the emerging pollutants, which need to be regulated. They have large potential of causing environment damage, ecosystems as well as human and animal health. Due to huge consumption of pharmaceuticals, effluents contains anti-diabetics, stimulant drugs, and antimicrobials compounds and many more. The decomposition of ECs is dependent on the chemical and biological persistence of ECs, their physicochemical characteristics, the technique applied, etc. The methods to trace and degrade/remove the PCs are very critical to address the issue. Several techniques have been adopted to minimize their hazards like adsorption, coagulation, constructed wetland, advanced oxidation process, membrane reactors (reverse osmosis, nanofiltration, microfiltration, etc.) and photocatalysis, etc. In this chapter, the different types of PCs and their affects will be summarized. The techniques involved to remove/degrade the compounds will also be discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Ahmadpour N, Sayadi MH, Sobhani S, Hajiani M (2020) Photocatalytic degradation of model pharmaceutical pollutant by novel magnetic TiO2@ZnFe2O4/Pd nanocomposite with enhanced photocatalytic activity and stability under solar light irradiation. J Environ Manag 271:110964

    Google Scholar 

  • Alkatheri AM, Alyousif SM, Alshabanah N, Abdulkareem M (2014) of Kidney diseases and transplantation original article medication adherence among adult patients on hemodialysis. Saudi J Kidney Dis Transpl 25:762–768

    Google Scholar 

  • Al-Khateeb LA, Almotiry S, Salam MA (2014) Adsorption of pharmaceutical pollutants onto graphene nanoplatelets. Chem Eng J 248:191–199

    CAS  Google Scholar 

  • Astas S (2008) Use of selected advanced oxidation processes (AOPs) for wastewater treatment—a mini review. Glob NEST J 10:376–385

    Google Scholar 

  • Baccar R, Sarrà M, Bouzid J, Feki M, Blánquez P (2012) Removal of pharmaceutical compounds by activated carbon prepared from agricultural by-product. Chem Eng J 211–212:310–317

    Google Scholar 

  • Badawy MI, Souaya EMR, Gad-Allah TA, Abdel-Wahed MS Ulbricht M (2014) Fabrication of Ag/TiO2 photocatalyst for the treatment of simulated hospital wastewater under sunlight. Environ Prog Sustain Energy 33:886–894

    Google Scholar 

  • Bhagawan D et al (2017) Industrial solid waste landfill leachate treatment using electrocoagulation and biological methods. Desalin Water Treat 68:137–142

    CAS  Google Scholar 

  • Bilgin Simsek E (2017) Solvothermal synthesized boron doped TiO2 catalysts: photocatalytic degradation of endocrine disrupting compounds and pharmaceuticals under visible light irradiation. Appl Catal B 200:309–322

    CAS  Google Scholar 

  • Blair B, Nikolaus A, Hedman C, Klaper R, Grundl T (2015) Evaluating the degradation, sorption, and negative mass balances of pharmaceuticals and personal care products during wastewater treatment. Chemosphere 134:395–401

    CAS  Google Scholar 

  • Bolong N, Ismail AF, Salim MR, Matsuura T (2009) A review of the effects of emerging contaminants in wastewater and options for their removal. Desalination 239:229–246

    CAS  Google Scholar 

  • Brahmi C et al (2021) Performance improvement of the photocatalytic process for the degradation of pharmaceutical compounds using new POM/polymer photocatalysts. J Environ Chem Eng 9:106015

    Google Scholar 

  • Bui TX, Pham VH, Le ST, Choi H (2013) Adsorption of pharmaceuticals onto trimethylsilylated mesoporous SBA-15. J Hazard Mater 254–255:345–353

    Google Scholar 

  • Burns WG, Sims HE (1981) Effect of radiation type in water radiolysis. J Chem Soc, Faraday Trans 1: Phys Chem Condens Phases 77:2803–2813

    Google Scholar 

  • Carballa M, Omil F, Lema JM (2005) Removal of cosmetic ingredients and pharmaceuticals in sewage primary treatment. Water Res 39:4790–4796

    CAS  Google Scholar 

  • Chakraborty S et al (2017) Photocatalytic hollow fiber membranes for the degradation of pharmaceutical compounds in wastewater. J Environ Chem Eng 5:5014–5024

    CAS  Google Scholar 

  • Chandrashekar Kollarahithlu S, Balakrishnan RM (2021) Adsorption of pharmaceuticals pollutants, ibuprofen, acetaminophen, and streptomycin from the aqueous phase using amine functionalized superparamagnetic silica nanocomposite. J Clean Prod 294:126155

    Google Scholar 

  • Chaves M de JS et al. (2020) Pharmaceuticals and personal care products in a Brazilian wetland of international importance: occurrence and environmental risk assessment. Sci Total Environ 734:139374

    Google Scholar 

  • Chon K, Kim SJ, Moon J, Cho J (2012) Combined coagulation-disk filtration process as a pretreatment of ultrafiltration and reverse osmosis membrane for wastewater reclamation: an autopsy study of a pilot plant. Water Res 46:1803–1816

    CAS  Google Scholar 

  • Cimetiere N, Soutrel I, Lemasle M, Laplanche A, Crocq A (2013) Standard addition method for the determination of pharmaceutical residues in drinking water by SPE–LC–MS/MS. Environ Technol 34:3031–3041

    CAS  Google Scholar 

  • Comeau F, Surette C, Brun GL, Losier R (2008) The occurrence of acidic drugs and caffeine in sewage effluents and receiving waters from three coastal watersheds in Atlantic Canada. Sci Total Environ 396:132–146

    CAS  Google Scholar 

  • Cuhorka J, Wallace E, Mikulášek P (2020) Removal of micropollutants from water by commercially available nanofiltration membranes. Sci Total Environ 720:137474

    Google Scholar 

  • Cunningham VL, Binks SP, Olson MJ (2009) Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment. Regul Toxicol Pharmacol 53:39–45

    CAS  Google Scholar 

  • De Andrade JR, Oliveira MF, Da Silva MGC, Vieira MGA (2018) Adsorption of pharmaceuticals from water and wastewater using nonconventional low-cost materials: a review. Ind Eng Chem Res 57:3103–3127

    Google Scholar 

  • Delgado N, Capparelli A, Navarro A, Marino D (2019) Pharmaceutical emerging pollutants removal from water using powdered activated carbon: study of kinetics and adsorption equilibrium. J Environ Manage 236:301–308

    CAS  Google Scholar 

  • Dharupaneedi SP et al (2019) Membrane-based separation of potential emerging pollutants. Sep Purif Technol 210:850–866

    CAS  Google Scholar 

  • Dhinesh Kumar R, Jayavel R (2014) Facile hydrothermal synthesis and characterization of LaFeO3 nanospheres for visible light photocatalytic applications. J Mater Sci: Mater Electron 25:3953–3961

    Google Scholar 

  • Ebele AJ, Abou-Elwafa Abdallah M, Harrad S (2017) Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment. Emerg Contam 3:1–16

    Google Scholar 

  • Egbuna C et al (2021) Emerging pollutants in Nigeria: a systematic review. Environ Toxicol Pharmacol 85:103638

    Google Scholar 

  • Elizalde-Velázquez A et al (2016) Amoxicillin in the aquatic environment, its fate and environmental risk. Environ Health Risk—Hazard Factors Living Species. https://doi.org/10.5772/62049

    Article  Google Scholar 

  • Fan H, Li J, Zhang L, Feng L (2014) Contribution of sludge adsorption and biodegradation to the removal of five pharmaceuticals in a submerged membrane bioreactor. Biochem Eng J 88:101–107

    CAS  Google Scholar 

  • Femina Carolin C, Senthil Kumar P, Janet Joshiba G, Vinoth Kumar V (2021) Analysis and removal of pharmaceutical residues from wastewater using membrane bioreactors: a review. Environ Chem Lett 19:329–343

    Google Scholar 

  • Fernández-López C, Guillén-Navarro JM, Padilla JJ, Parsons JR (2016) Comparison of the removal efficiencies of selected pharmaceuticals in wastewater treatment plants in the region of Murcia, Spain. Ecol Eng 95:811–816

    Google Scholar 

  • Flaherty CM, Dodson SI (2005) Effects of pharmaceuticals on Daphnia survival, growth, and reproduction. Chemosphere 61:200–207

    CAS  Google Scholar 

  • Focazio MJ et al (2008) A national reconnaissance for pharmaceuticals and other organic wastewater contaminants in the United States—II) Untreated drinking water sources. Sci Total Environ 402:201–216

    CAS  Google Scholar 

  • Fram MS, Belitz K (2011) Occurrence and concentrations of pharmaceutical compounds in groundwater used for public drinking-water supply in California. Sci Total Environ 409:3409–3417

    CAS  Google Scholar 

  • Ganzenko O et al (2018) Bioelectro-Fenton: evaluation of a combined biological—advanced oxidation treatment for pharmaceutical wastewater. Environ Sci Pollut Res 25:20283–20292

    CAS  Google Scholar 

  • Goswami L et al (2018) Membrane bioreactor and integrated membrane bioreactor systems for micropollutant removal from wastewater: a review. J Water Process Eng 26:314–328

    Google Scholar 

  • Grandclément C et al (2017) From the conventional biological wastewater treatment to hybrid processes, the evaluation of organic micropollutant removal: a review. Water Res, 297–317

    Google Scholar 

  • Hena S, Gutierrez L, Croué JP (2021) Removal of pharmaceutical and personal care products (PPCPs) from wastewater using microalgae: a review. J Hazard Mater 403

    Google Scholar 

  • Hernandez-Ruiz S, Abrell L, Wickramasekara S, Chefetz B, Chorover J (2012) Quantifying PPCP interaction with dissolved organic matter in aqueous solution: combined use of fluorescence quenching and tandem mass spectrometry. Water Res 46:943–954

    CAS  Google Scholar 

  • Ji K et al (2010a) Effects of sulfathiazole, oxytetracycline and chlortetracycline on steroidogenesis in the human adrenocarcinoma (H295R) cell line and freshwater fish Oryzias latipes. J Hazard Mater 182:494–502

    Google Scholar 

  • Ji L, Shao Y, Xu Z, Zheng S, Zhu D (2010b) Adsorption of monoaromatic compounds and pharmaceutical antibiotics on carbon nanotubes activated by KOH etching. Environ Sci Technol 44:6429–6436

    Google Scholar 

  • Kalaji HM, Rastogi A (2017) Pharmaceutical compounds: an emerging pollutant (A review on plant-pharmaceuticals interaction). Chiang Mai J Sci

    Google Scholar 

  • Kanakaraju D, Glass BD, Oelgemöller M (2014) Titanium dioxide photocatalysis for pharmaceutical wastewater treatment. Environ Chem Lett 12:27–47

    CAS  Google Scholar 

  • Khalil AME et al (2020) Nanostructured porous graphene for efficient removal of emerging contaminants (pharmaceuticals) from water. Chem Eng J 398:125440

    Google Scholar 

  • Korhonen C, Peterson K, Bruder C, Jung P (2007) Self-reported adverse events associated with antimalarial chemoprophylaxis in peace corps volunteers. Am J Prev Med 33:194–199

    Google Scholar 

  • Lapworth DJ, Baran N, Stuart ME, Ward RS (2012) Emerging organic contaminants in groundwater: a review of sources, fate and occurrence. Environ Pollut, 287–303

    Google Scholar 

  • Lee CS, Robinson J, Chong MF (2014) A review on application of flocculants in wastewater treatment. Process Saf Environ Prot, 489–508

    Google Scholar 

  • Li S et al (2020) Facile construction of novel Bi2WO6/Ta3N5 Z-scheme heterojunction nanofibers for efficient degradation of harmful pharmaceutical pollutants. Chem Eng J 402:126165

    Google Scholar 

  • Li X, Li G (2015) A review: pharmaceutical wastewater treatment technology and research in China. In: Proceedings of the 2015 Asia-Pacific Energy Equipment Engineering Research Conference 9:345–348

    Google Scholar 

  • Li Y, Zhu G, Ng WJ, Tan SK (2014) A review on removing pharmaceutical contaminants from wastewater by constructed wetlands: design, performance and mechanism. Sci Total Environ, 908–932

    Google Scholar 

  • Liu X et al (2019) A review on removing antibiotics and antibiotic resistance genes from wastewater by constructed wetlands: performance and microbial response. Environ Pollut 254:112996

    Google Scholar 

  • López-Serna R et al (2013) Occurrence of 95 pharmaceuticals and transformation products in urban groundwaters underlying the metropolis of Barcelona, Spain. Environ Pollut 174:305–315

    Google Scholar 

  • Méndez-Arriaga F, Gimenez J, Esplugas S (2008) Photolysis and TiO2 photocatalytic treatment of naproxen: degradation, mineralization, intermediates and toxicity. J Adv Oxid Technol 11:435–444

    Google Scholar 

  • Mezzelani M, Gorbi S, Regoli F (2018) Pharmaceuticals in the aquatic environments: evidence of emerged threat and future challenges for marine organisms. Mar Environ Res 140:41–60

    CAS  Google Scholar 

  • Narvaez JFV, Jimenez CC (2012) Pharmaceutical products in the environment: sources, effects and risks/Productos Farmacéuticos En El Ambiente: Fuentes, Efectos Y Riesgos. Vitae 19:93–108

    Google Scholar 

  • Oller I, Malato S (2021) Photo-Fenton applied to the removal of pharmaceutical and other pollutants of emerging concern. Curr Opin Green Sustain Chem 29:100458

    Google Scholar 

  • Papageorgiou M, Kosma C, Lambropoulou D (2016) Seasonal occurrence, removal, mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece. Sci Total Environ 543:547–569

    CAS  Google Scholar 

  • Park J, Yamashita N, Wu G, Tanaka H (2017) Removal of pharmaceuticals and personal care products by ammonia oxidizing bacteria acclimated in a membrane bioreactor: contributions of cometabolism and endogenous respiration. Sci Total Environ 605–606:18–25

    Google Scholar 

  • Park J et al (2021) Determination of pharmaceuticals in solid samples in municipal wastewater treatment plants by online SPE LC–MS/MS using QuEChERS extraction. Environ Monit Assess 193:279

    CAS  Google Scholar 

  • Paul T, Miller PL, Strathmann TJ (2007) Visible-light-mediated TiO2 photocatalysis of fluoroquinolone antibacterial agents. Environ Sci Technol 41:4720–4727

    CAS  Google Scholar 

  • Pauletto PS, Lütke SF, Dotto GL, Salau NPG (2021) Adsorption mechanisms of single and simultaneous removal of pharmaceutical compounds onto activated carbon: isotherm and thermodynamic modeling. J Mol Liq 336:116203

    Google Scholar 

  • Petrovic M et al (2008) Emerging contaminants in waste waters: sources and occurrence. Handb Environ Chem, 5. Water Pollut 5 S1:1–35

    Google Scholar 

  • Plósz BG, Langford KH, Thomas KV (2012) An activated sludge modeling framework for xenobiotic trace chemicals (ASM-X): assessment of diclofenac and carbamazepine. Biotechnol Bioeng 109:2757–2769

    Google Scholar 

  • Ramasundaram S et al (2013) Titanium dioxide nanofibers integrated stainless steel filter for photocatalytic degradation of pharmaceutical compounds. J Hazard Mater 258–259:124–132

    Google Scholar 

  • Rehman MSU et al (2015) Global risk of pharmaceutical contamination from highly populated developing countries. Chemosphere 138:1045–1055

    CAS  Google Scholar 

  • Rey A et al (2014) WO3–TiO2 based catalysts for the simulated solar radiation assisted photocatalytic ozonation of emerging contaminants in a municipal wastewater treatment plant effluent. Appl Catal B 154–155:274–284

    Google Scholar 

  • Richardson SD (2007) Water analysis: emerging contaminants and current issues. Anal Chem, 4295–4323

    Google Scholar 

  • Rivera-Utrilla J, Sánchez-Polo M, Ferro-García MÁ, Prados-Joya G, Ocampo-Pérez R (2013) Pharmaceuticals as emerging contaminants and their removal from water. A review. Chemosphere, 1268–1287

    Google Scholar 

  • Roberts J et al (2016) Pharmaceuticals and personal care products (PPCPs) in Australia’s largest inland sewage treatment plant, and its contribution to a major Australian river during high and low flow. Sci Total Environ 541:1625–1637

    CAS  Google Scholar 

  • Salgado R et al (2012) Assessing the removal of pharmaceuticals and personal care products in a full-scale activated sludge plant. Environ Sci Pollut Res 19:1818–1827

    CAS  Google Scholar 

  • Schröder HF et al (2012) The removal and degradation of pharmaceutical compounds during membrane bioreactor treatment. Water Sci Technol 65:833–839

    Google Scholar 

  • Simazaki D et al (2015) Occurrence of selected pharmaceuticals at drinking water purification plants in Japan and implications for human health. Water Res 76:187–200

    CAS  Google Scholar 

  • Sun H, Wang T, Yang Z, Yu C, Wu W (2019) Simultaneous removal of nitrogen and pharmaceutical and personal care products from the effluent of waste water treatment plants using aerated solid-phase denitrification system. Bioresour Technol 287:121389

    Google Scholar 

  • Tang H et al (2013) Hydrothermal synthesis and visible-light photocatalytic activity of α-Fe2O3/TiO2 composite hollow microspheres. Ceram Int 39:8633–8640

    CAS  Google Scholar 

  • Taoufik N et al (2020) Removal of emerging pharmaceutical pollutants: a systematic mapping study review. J Environ Chem Eng 8

    Google Scholar 

  • Teoh WY, Mädler L, Beydoun D, Pratsinis SE, Amal R (2005) Direct (one-step) synthesis of TiO2 and Pt/TiO2 nanoparticles for photocatalytic mineralisation of sucrose. Chem Eng Sci 60:5852–5861

    CAS  Google Scholar 

  • Ternes TA (1998) Occurrence of drugs in German sewage treatment plants and rivers. Water Res 32:3245–3260

    CAS  Google Scholar 

  • Thiebault T, Guégan R, Boussafir M (2015) Adsorption mechanisms of emerging micro-pollutants with a clay mineral: case of tramadol and doxepine pharmaceutical products. J Colloid Interface Sci 453:1–8

    CAS  Google Scholar 

  • Varma KS et al (2020) Photocatalytic degradation of pharmaceutical and pesticide compounds (PPCs) using doped TiO2 nanomaterials: a review. Water-Energy Nexus 3:46–61

    Google Scholar 

  • Velempini T, Prabakaran E, Pillay K (2021a) Recent developments in the use of metal oxides for photocatalytic degradation of pharmaceutical pollutants in water—a review. Mater Today Chem

    Google Scholar 

  • Velempini T, Prabakaran E, Pillay K (2021) Recent developments in the use of metal oxides for photocatalytic degradation of pharmaceutical pollutants in water—a review. Mater Today Chem 19:100380

    Google Scholar 

  • Vieno NM, Tuhkanen T, Kronberg L (2006) Analysis of neutral and basic pharmaceuticals in sewage treatment plants and in recipient rivers using solid phase extraction and liquid chromatography–tandem mass spectrometry detection. J Chromatogr A 1134:101–111

    CAS  Google Scholar 

  • Villegas- Guzman P et al (2017) A green solar photo-Fenton process for the elimination of bacteria and micropollutants in municipal wastewater treatment using mineral iron and natural organic acids. Appl Catal B: Environ 219:538–549

    Google Scholar 

  • Wanda EMM, Nyoni H, Mamba BB, Msagati TAM (2017) Occurrence of emerging micropollutants in water systems in Gauteng, Mpumalanga, and North West provinces, South Africa. Int J Environ Res Public Health 14:8–20

    Google Scholar 

  • Wang J, Wang S (2016) Removal of pharmaceuticals and personal care products (PPCPs) from wastewater: a review. J Environ Manage 182:620–640

    CAS  Google Scholar 

  • Wenten IG (2003) Recent development in membrane science and its industrial applications. J Sci Technol 24:1009–1024

    Google Scholar 

  • Wilkinson J, Hooda PS, Barker J, Barton S, Swinden J (2017) Occurrence, fate and transformation of emerging contaminants in water: an overarching review of the field. Environ Pollut 231:954–970

    CAS  Google Scholar 

  • Xiang Y, Fang J, Shang C (2016) Kinetics and pathways of ibuprofen degradation by the UV/chlorine advanced oxidation process. Water Res 90:301–308

    CAS  Google Scholar 

  • Yang J, Zhong H, Li M, Zhang L, Zhang Y (2009) Markedly enhancing the visible-light photocatalytic activity of LaFeO3 by post-treatment in molten salt. React Kinet Catal Lett 97:269–274

    CAS  Google Scholar 

  • Yoon Y, Westerhoff P, Snyder SA, Esparza M (2003) HPLC-fluorescence detection and adsorption of bisphenol A, 17β-estradiol, and 17α-ethynyl estradiol on powdered activated carbon. Water Res 37:3530–3537

    CAS  Google Scholar 

  • Yuan F, Hu C, Hu X, Qu J, Yang M (2009) Degradation of selected pharmaceuticals in aqueous solution with UV and UV/H2O2. Water Res 43:1766–1774

    CAS  Google Scholar 

  • Zaviska F, Drogui P, Grasmick A, Azais A, Héran M (2013) Nanofiltration membrane bioreactor for removing pharmaceutical compounds. J Membr Sci 429:121–129

    CAS  Google Scholar 

  • Zhang R et al (2019) Highly effective removal of pharmaceutical compounds from Aqueous solution by magnetic Zr-based MOFs composites. Ind Eng Chem Res 58:3876–3884

    CAS  Google Scholar 

  • Zhang L et al (2020) Occurrence, distribution, and ecological risk of pharmaceuticals in a seasonally ice-sealed river: From ice formation to melting. J Hazard Mater 389:122083

    Google Scholar 

  • Zheng Q et al (2014) Electrochromic titania nanotube arrays for the enhanced photocatalytic degradation of phenol and pharmaceutical compounds. Chem Eng J 249:285–292

    CAS  Google Scholar 

  • Zotou A, Miltiadou N (2002) Sensitive LC determination of ciprofloxacin in pharmaceutical preparations and biological fluids with fluorescence detection. J Pharm Biomed Anal 28:559–568

    CAS  Google Scholar 

  • Żyłła R, Boruta T, Gmurek M, Milala R, Ledakowicz S (2019) Integration of advanced oxidation and membrane filtration for removal of micropollutants of emerging concern. Process Saf Environ Prot 130:67–76

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Narendra Singh .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Lakshmi, C.N., Singh, N. (2022). Removal of Pharmaceutical Compounds: Overview of Treatment Methods. In: P. Singh, S., Agarwal, A.K., Gupta, T., Maliyekkal, S.M. (eds) New Trends in Emerging Environmental Contaminants. Energy, Environment, and Sustainability. Springer, Singapore. https://doi.org/10.1007/978-981-16-8367-1_8

Download citation

Publish with us

Policies and ethics