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Autophagy in Aging and Longevity

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Aging Mechanisms II

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Abstract

Macroautophagy (autophagy) is an evolutionally conserved cytoplasmic degradation system in which varieties of materials are sequestered by a double membrane structure, called autophagosome, and delivered to the lysosomes for the degradation. Due to the wide varieties of targets, autophagic activity is essential for cellular homeostasis and survival. Accumulating evidences suggest that the activity of autophagy decreases with age, whereas several interventions which induce activation of autophagy promote longevity and prevents age-related diseases. Here we summarize recent progress regarding the role of autophagy in animal aging and life span regulation.

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Authors and Affiliations

  1. Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan

    Shuhei Nakamura, Tatsuya Shioda & Tamotsu Yoshimori

Authors
  1. Shuhei Nakamura
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  2. Tatsuya Shioda
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  3. Tamotsu Yoshimori
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Correspondence to Shuhei Nakamura .

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Editors and Affiliations

  1. Fukuoka International University of Health and Welfare, Fukuoka, Japan

    Nozomu Mori

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Nakamura, S., Shioda, T., Yoshimori, T. (2022). Autophagy in Aging and Longevity. In: Mori, N. (eds) Aging Mechanisms II . Springer, Singapore. https://doi.org/10.1007/978-981-16-7977-3_11

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