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Crystallization and Polymorphism of Amino Acids Controlled by High-Repetition-Rate Femtosecond Laser Pulses

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High-Energy Chemistry and Processing in Liquids

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Abstract

This chapter first reviews the history of laser-induced crystallization and polymorphism control and then presents the experimental results on crystallization and polymorphism obtained by high-repetition-rate femtosecond laser irradiation, which is based on various physical phenomena (optical trapping and laser ablation). Femtosecond laser pulses are focused on clusters of amino acid solutions (L-phenylalanine (L-Phe) and L-serine (L-Ser)) in solution. These clusters are gathered at a high local concentration in the focal volume, eventually leading to crystal nucleation. This phenomenon is called optical trapping-induced crystallization (OTIC). OTIC yields crystals with different molecular arrangements (polymorphs) depending on the laser irradiation conditions. Among the reported polymorphs are monohydrate and anhydrous crystals of both L-Phe and L-Ser, which exhibit similar thermal behaviors. However, unlike L-Ser, L-Phe has a benzene moiety in its chemical structure, so its crystallization and polymorphism phenomena are governed by multiphoton absorption under femtosecond laser irradiation and essentially differ from those of L-Ser. Herein, the mechanism of polymorph control is uniformly discussed in terms of classical nucleation theory. Polymorphs are controlled by the degree of local concentration achieved by laser irradiation. All phenomena and experimental results presented in this chapter are characteristic of high-energy lasers and provide many insights into the emerging field of high-energy chemistry.

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Authors and Affiliations

  1. Department of Applied Chemistry, National Yang Ming Chiao Tung University, 1001 University Road, Hsinchu, 30010, Taiwan

    Teruki Sugiyama

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  1. Teruki Sugiyama
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Correspondence to Teruki Sugiyama .

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Editors and Affiliations

  1. National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan

    Yoshie Ishikawa

  2. Tohoku University, Sendai, Japan

    Takahiro Nakamura

  3. >National Institutes for Quantum Science and Technology (QST), Takasaki, Japan

    Morihisa Saeki

  4. National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan

    Tadatake Sato

  5. National Yang Ming Chiao Tung University, Hsinchu City, Taiwan

    Teruki Sugiyama

  6. Tokyo Institute of Technology, Yokohama, Japan

    Hiroyuki Wada

  7. Osaka City University, Osaka, Japan

    Tomoyuki Yatsuhashi

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Sugiyama, T. (2022). Crystallization and Polymorphism of Amino Acids Controlled by High-Repetition-Rate Femtosecond Laser Pulses. In: Ishikawa, Y., et al. High-Energy Chemistry and Processing in Liquids. Springer, Singapore. https://doi.org/10.1007/978-981-16-7798-4_15

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