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Nanotechnology in Venom Research: Recent Trends and Its Application

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Nanotechnology for Biomedical Applications

Abstract

Nanotechnology is a cutting-edge technology facilitating involvement, development, and viable effect on nanomedicine and nanoscience. With the recent trends and developments in nanotechnology, the scenarios of applied engineered nanomaterials in industrial applications, biomedical research, drug delivery, disease diagnoses, antivenom activity, cancer treatment, and other fields have improved speedily. The potential for nanotechnology in venom research that is endless, with original, innovative solicitations continuously being explored. Venom or animal toxin is a unique bioresource of different dynamic constituents, which have revealed significant and promising application in medical science. The ongoing nanotechnology science is joint with emerging venom study and amalgamation these two distinctive areas should be known as “Venom Nanotechnology.” Recent developments in venom nanotechnology, the impetus, or intent is clearly articulated to treating chronic human diseases by target-specific, competent delivery of drugs or therapeutic molecules, augment drug solubility, enhanced stability, reduced toxicity, bioavailability, and drug stability. In this chapter, a comprehensive overview to the utilization of venom nanomaterial-based formulations on the treatment of different type’s cancer and infectious diseases along with green synthesized nanoparticles as an antidote against snake venom for life-saving was discussed. We also emphasize the need for future research for broad commercialization of nano-based formulations in snake venom research aiming a positive impact on public health.

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References

  1. Kumar S, Bhushan P, Bhattacharya S (2018) Fabrication of nanostructures with bottom-up approach and their utility in diagnostics, therapeutics, and others. In: Environmental, chemical and medical sensors. pp 167–198. https://doi.org/10.1007/978-981-10-7751-7_8

  2. Jeevanandam J, Barhoum A, Chan YS, Dufresne A, Danquah MK (2018) Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations. Beilstein J Nanotechnol 9:1050–1074. https://doi.org/10.3762/bjnano.9.98

    Article  Google Scholar 

  3. Mohamed Abd El-Aziz T, Garcia Soares A, Stockand JD (2019) Snake venoms in drug discovery: valuable therapeutic tools for life saving. Toxins (Basel). 11:564. https://doi.org/10.3390/toxins11100564

  4. Singh P, Yasir M, Hazarika R, Sugunan S, Shrivastava R (2017) A review on venom enzymes neutralizing ability of secondary metabolites from medicinal plants. J Pharmacopuncture 20:173–178. https://doi.org/10.3831/KPI.2017.20.020

    Article  Google Scholar 

  5. Saha P, Bhowmik T, Dasgupta A, Gomes A (2014) Nano gold conjugation, anti-arthritic potential and toxicity studies of snake Naja kaouthia (Lesson, 1831) venom protein toxin NKCT1 in male albino rats and mice. Indian J Exp Biol 52:763–772

    Google Scholar 

  6. Bhowmik T, Gomes A (2016) NKCT1 (purified Naja kaouthia protein toxin) conjugated gold nanoparticles induced Akt/mTOR inactivation mediated autophagic and caspase 3 activated apoptotic cell death in leukemic cell. Toxicon 121:86–97. https://doi.org/10.1016/j.toxicon.2016.08.004

  7. Gomes A, Saha PP, Bhowmik T, Dasgupta AK, Dasgupta SC (2016a) Protection against osteoarthritis in experimental animals by nanogold conjugated snake venom protein toxin gold nanoparticle-Naja kaouthia cytotoxin 1. Indian J Med Res. https://doi.org/10.4103/ijmr.IJMR_1078_14

    Article  Google Scholar 

  8. Bhowmik T, Saha PP, Sarkar A, Gomes A (2017) Evaluation of cytotoxicity of a purified venom protein from Naja kaouthia (NKCT1) using gold nanoparticles for targeted delivery to cancer cell. Chem Biol Interact 261:35–49. https://doi.org/10.1016/j.cbi.2016.11.007

  9. Attarde SS, Pandit SV (2020) Anticancer potential of nanogold conjugated toxin GNP-NN-32 from Naja naja venom. J Venom Anim Toxins Incl Trop Dis 26:e20190047–e20190047. https://doi.org/10.1590/1678-9199-JVATITD-2019-0047

    Article  CAS  Google Scholar 

  10. Fu Y, An N, Li K, Zheng Y, Liang A (2012) Chlorotoxin-conjugated nanoparticles as potential glioma-targeted drugs. J Neurooncol 107:457–462. https://doi.org/10.1007/s11060-011-0763-6

    Article  CAS  Google Scholar 

  11. Jalaei J, Layeghi-Ghalehsoukhteh S, Hosseini A, Fazeli M (2018) Antibacterial effects of gold nanoparticles functionalized with the extracted peptide from Vespa orientalis wasp venom. J Pept Sci 24:e3124. https://doi.org/10.1002/psc.3124

  12. Al-Sadoon MK, Rabah DM, Badr G (2013) Enhanced anticancer efficacy of snake venom combined with silica nanoparticles in a murine model of human multiple myeloma: molecular targets for cell cycle arrest and apoptosis induction. Cell Immunol 284:129–138. https://doi.org/10.1016/j.cellimm.2013.07.016

  13. Badr G, Al-Sadoon MK, Rabah DM (2013) Therapeutic efficacy and molecular mechanisms of snake (Walterinnesia aegyptia) venom-loaded silica nanoparticles in the treatment of breast cancer- and prostate cancer-bearing experimental mouse models. Free Radic Biol Med 65:175–189. https://doi.org/10.1016/j.freeradbiomed.2013.06.018

  14. Bala E, Hazarika R, Singh P, Yasir M, Shrivastava R (2018) A biological overview of Hyaluronidase: a venom enzyme and its inhibition with plants materials. In: Materials today: proceedings. https://doi.org/10.1016/j.matpr.2017.12.252

  15. Singh P, Yasir M, Shrivastava R (2019) Screening and identification of plant metabolites against snake venom enzymes using in vitro to in silico approach. Indian J Pharm Educ Res 53:s607–s618. https://doi.org/10.5530/ijper.53.4s.156

    Article  CAS  Google Scholar 

  16. Mahamadi C, Wunganayi T (2018) Green synthesis of silver nanoparticles using Zanthoxylum chalybeum and their antiprolytic and antibiotic properties. Cogent Chem 4:1–12. https://doi.org/10.1080/23312009.2018.1538547

    Article  CAS  Google Scholar 

  17. Singh P, Yasir M, Khare R, Shrivastava R (2020) Green synthesis of silver nanoparticles using Indian male fern (Dryopteris Cochleata), operational parameters, characterization and bioactivity on Naja naja venom neutralization. Toxicol Res (Camb) 9:706–713. https://doi.org/10.1093/toxres/tfaa070

    Article  Google Scholar 

  18. Ghosh S, Dasgupta SC, Dasgupta AK, Gomes A, Gomes A (2020) Gold Nanoparticles (AuNPs) conjugated with andrographolide ameliorated viper (Daboia russellii russellii) venom-induced toxicities in animal model. J Nanosci Nanotechnol 20:3404–3414. https://doi.org/10.1166/jnn.2020.17421

    Article  CAS  Google Scholar 

  19. Gomes A, Sengupta J, Ghosh S, Gomes A (2016b) Application of gold nanoparticle conjugation with 2-hydroxy-4-methoxy benzoic acid (HMBA) from hemidesmus indicus root enhancing neutralization of snake (Viper) venom activity. J Nanosci Nanotechnol. https://doi.org/10.1166/jnn.2016.11777

    Article  Google Scholar 

  20. Oliveira ICF, de Paula MO, Lastra HCB, de Alves BB, Moreno DAN, Yoshida EH, Amaral Filho J, Cogo JC, Varanda EA, Rai M, dos Santos CA, Oshima-Franco Y (2019) Activity of silver nanoparticles on prokaryotic cells and Bothrops jararacussu snake venom. Drug Chem Toxicol 42:60–64. https://doi.org/10.1080/01480545.2018.1478850

  21. Chakrabartty S, Alam MI, Bhagat S, Alam A, Dhyani N, Khan GA, Alam MS (2019) Inhibition of snake venom induced sterile inflammation and PLA2 activity by Titanium dioxide Nanoparticles in experimental animals. Sci Rep 9:11175. https://doi.org/10.1038/s41598-019-47557-y

    Article  CAS  Google Scholar 

  22. Bukke S, Beeram E, Divya B, Pallavi C, Venkataswamy M, Kemparaj KKT (2018) Effect of silver nano particles synthesized of Trichodesma indicum against Naja Naja (Cobra) Venom. Int J Pharm Sci Res. https://doi.org/10.13040/ijpsr.0975-8232.9(8).3291-96

  23. O’Brien J, Lee S-H, Gutiérrez JM, Shea KJ (2018) Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis. PLoS Negl Trop Dis 12:e0006736–e0006736. https://doi.org/10.1371/journal.pntd.0006736

    Article  CAS  Google Scholar 

  24. Saha K, Gomes A (2017) Russell’s viper venom induced nephrotoxicity, myotoxicity, and hepatotoxicity—Neutralization with gold nanoparticle conjugated 2-hydroxy-4-methoxy benzoic acid in vivo. Indian J Exp Biol 55:7–14

    CAS  Google Scholar 

  25. Hingane VC, Pangam D, Dongre PM (2018) Inhibition of crude viper venom action by silver nanoparticles: a biophysical and biochemical study. Biophys Physicobiol 15:204–213. https://doi.org/10.2142/biophysico.15.0_204

    Article  CAS  Google Scholar 

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Correspondence to Dhruv Kumar .

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Singh, P., Tripathi, M.K., Kumar, D. (2022). Nanotechnology in Venom Research: Recent Trends and Its Application. In: Gopi, S., Balakrishnan, P., Mubarak, N.M. (eds) Nanotechnology for Biomedical Applications. Materials Horizons: From Nature to Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-16-7483-9_17

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