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Pathophysiology of Cerebral Aneurysms

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Endovascular Surgery of Cerebral Aneurysms

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Abstract

Understanding the pathophysiology of the formation and growth of cerebral aneurysms is crucial for early detection, risk assessment, and therapeutic monitoring of intracranial aneurysms. A multifactorial model can be applied to study the formation and growth of cerebral aneurysms. This model is mainly based on patient and aneurysm-specific characteristics. Potential patient-specific factors include smoking status, hypertension, inflammatory disease, bone mineral loss, and sex hormone exposure. Aneurysm-specific factors include aneurysm size, bifurcation site, multiplicity, presence of a daughter sac, higher dome-to-neck ratio, multi-lobularity, and adjacent arterial geometry. Other factors that can affect the development and growth of aneurysms include female sex, short stature, bone fragility, malnutrition, and the existence of genetic disorders, and a range of aortic pathologies, including bicuspid aortic valve, dilated aortic root, aortic aneurysm, and arterial dissection. The goal of this chapter is to summarize the existing evidence and potential prospects for cerebral aneurysm pathophysiological studies.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Washington, Seattle, WA, USA

    Zaid Aljuboori

  2. Department of Neurosurgery, Neurosurgery Teaching Hospital, Baghdad, Iraq

    Samer S. Hoz, Zahraa Al-Sharshahi & Mohammed A. Alrawi

Authors
  1. Zaid Aljuboori
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  2. Samer S. Hoz
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  3. Zahraa Al-Sharshahi
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  4. Mohammed A. Alrawi
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Corresponding author

Correspondence to Zaid Aljuboori .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China

    Xianli Lv

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Aljuboori, Z., Hoz, S.S., Al-Sharshahi, Z., Alrawi, M.A. (2022). Pathophysiology of Cerebral Aneurysms. In: Lv, X. (eds) Endovascular Surgery of Cerebral Aneurysms. Springer, Singapore. https://doi.org/10.1007/978-981-16-7102-9_1

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  • DOI: https://doi.org/10.1007/978-981-16-7102-9_1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-7101-2

  • Online ISBN: 978-981-16-7102-9

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