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Role of Homocysteine Metabolism in Cardiovascular Diseases

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Homocysteine Metabolism in Health and Disease

Abstract

Homocysteine is a methyl group metabolic intermediate that requires numerous B-vitamin cofactors in the diet to function properly. The relationship between homocysteine metabolism and health and disease is becoming more well-known. Homocysteine metabolism disturbances, primarily intracellular and subsequent circulatory homocysteine buildup (hyperhomocysteinemia), are linked to vascular disease risk and other diseases. On the other hand, B-vitamin treatment has successfully restored average homocysteine concentrations without corresponding decreases in disease risk. As a result, researchers are still investigating the molecular link between homocysteine equilibrium and disease states and the efficacy of homocysteine regulation.

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Authors and Affiliations

  1. Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, Uttar Pradesh, India

    Prashant Kumar

  2. Department of Biotechnology, B. N. College of Engineering & Technology, Lucknow, Uttar Pradesh, India

    Sunil Kumar Verma

  3. School of Pharmacy, Chhatrapati Shahu Ji Maharaj University, Kanpur, Uttar Pradesh, India

    Sweta Rai

  4. Department of Biomedical Engineering, School of Engineering and Technology, Mody University, Sikar, Rajasthan, India

    P. Shakti Prakash

  5. Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, Uttar Pradesh, India

    Dheeraj Chitara

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  1. Kriya Sharira and Kaya Chikitsa, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Govind Prasad Dubey

  2. Department of Applied Sciences, Indian Institute of Information Technology (IIITA), Prayagraj, Uttar Pradesh, India

    Krishna Misra

  3. Department of Computer Application, Nehru Gram Bharati (Deemed to be University), Prayagraj, Uttar Pradesh, India

    Rajesh K. Kesharwani

  4. Department of Zoology, Nehru Gram Bharati (Deemed to be University), Prayagraj, Uttar Pradesh, India

    Rudra P. Ojha

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Kumar, P., Verma, S.K., Rai, S., Prakash, P.S., Chitara, D. (2022). Role of Homocysteine Metabolism in Cardiovascular Diseases. In: Dubey, G.P., Misra, K., Kesharwani, R.K., Ojha, R.P. (eds) Homocysteine Metabolism in Health and Disease. Springer, Singapore. https://doi.org/10.1007/978-981-16-6867-8_14

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