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A Guide to Botulinum Toxin and Fillers

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Skin Diseases in Females

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Abstract

The process of ageing on the face leads to dynamic wrinkles and static wrinkles. Botulinum toxin is a neuromodulator that relaxes targeted muscles, thereby reducing the intensity of contraction and dynamic wrinkling. Dermal fillers are used to replace lost volume due to loss of collagen, elastin, atrophy of deep fat pads and bone resorption. Fillers aid in contouring, lifting and rejuvenating ageing skin and are also used to enhance and accentuate facial features.

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References

  1. Parish LC, Crissey JT. Cosmetics: a historical review. Clin Dermatol. 1988;6(3):1–4.

    Article  CAS  PubMed  Google Scholar 

  2. Carruthers JD, Carruthers JA. Treatment of glabellar frown lines with C. botulinum-A exotoxin. J Dermatol Surg Oncol. 1992;18(1):17–21.

    Article  CAS  PubMed  Google Scholar 

  3. Source: The Aesthetic Society. https://www.surgery.org/sites/default/files/Top-5.pdf

  4. Schiavo G, Matteoli M, Montecucco C. Neurotoxins affecting neuroexocytosis. Physiol Rev. 2000;80(2):717–66.

    Article  CAS  PubMed  Google Scholar 

  5. Jankovic J, Brin MF. Therapeutic uses of botulinum toxin. N Engl J Med. 1991;324(17):1186–94.

    Article  CAS  PubMed  Google Scholar 

  6. Gart MS, Gutowski KA. Overview of botulinum toxins for aesthetic uses. Clin Plast Surg. 2016;43(3):459–71.

    Article  PubMed  Google Scholar 

  7. Bhidayasiri R, Truong D. Evidence for effectiveness of botulinum toxin for hyperhidrosis. J Neural Transm. 2008;115:641–5.

    Article  CAS  PubMed  Google Scholar 

  8. Wenzel RG. Pharmacology of botulinum neurotoxin serotype A. Am J Health Syst Pharm. 2004;61(6):5–10.

    Article  Google Scholar 

  9. Liu A, Carruthers A, Cohen JL, et al. Recommendations and current practices for the reconstitution and storage of botulinum toxin type A. J Am Acad Dermatol. 2012;67(3):373–8.

    Article  CAS  PubMed  Google Scholar 

  10. Gulec AT. Dilution of botulinum toxin A in lidocaine vs. in normal saline for the treatment of 429 primary axillary hyperhidrosis: a double-blind, randomized, comparative preliminary study. J Eur Acad Dermatol Venereol. 2012;26(3):314–8.

    Article  CAS  PubMed  Google Scholar 

  11. Hexsel DM, De Almeida AT, Rutowitsch M, et al. Multicenter, double-blind study of the efficacy of injections with botulinum toxin type A reconstituted up to six consecutive weeks before application. Dermatol Surg. 2003;29:523–9.

    PubMed  Google Scholar 

  12. Sloop RR, Cole BA, Escutin RO. Reconstituted botulinum toxin type A does not lose potency in humans if it is refrozen or refrigerated for 2 weeks before use. Arch Facial Plast Surg. 2008;10:273–9.

    Google Scholar 

  13. Shome D, Nair AH, Kapoor R, et al. Botulinum toxin A: is it really that fragile a molecule? Dermatol Surg. 2010;36:2106–10.

    Article  CAS  PubMed  Google Scholar 

  14. Flynn TC. Botulinum toxin: examining duration of effect in facial aesthetic applications. Am J Clin Dermatol. 2010;11(3):189–99.

    Article  Google Scholar 

  15. Campanati A, Martina E, Giuliodori K, et al. Botulinum toxin off-label use in dermatology: a review. Skin Appendage Disord. 2017;3(1):39–56.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Ascher B, Talarico S, Cassuto D, et al. International consensus recommendations on the aesthetic usage of botulinum toxin type A (Speywood Unit): part I. Upper facial wrinkles. J Eur Acad Dermatol Venereol. 2010;24(11):1278–84.

    Article  CAS  PubMed  Google Scholar 

  17. Frankel AS, Kamer FM. Chemical browlift. Arch Otolaryngol Head Neck Surg. 1998;124(3):321–3.

    Article  CAS  PubMed  Google Scholar 

  18. Carruthers J, Carruthers A. Aesthetic botulinum A toxin in the mid and lower face and neck. Dermatol Surg. 2003;29(5):468–76.

    PubMed  Google Scholar 

  19. Alam M, Tung R. Injection technique in neurotoxins and fillers: indications, products, and outcomes. J Am Acad Dermatol. 2018;79(3):423–35. https://doi.org/10.1016/j.jaad.2018.01.037.

    Article  CAS  PubMed  Google Scholar 

  20. Cheng J, Hsu SH, McGee JS. Botulinum toxin injections for masseter reduction in East Asians. Dermatol Surg. 2019;45(4):566–72.

    Article  CAS  PubMed  Google Scholar 

  21. Sepehr A, Chauhan N, Alexander AJ, et al. Botulinum toxin type A for facial rejuvenation: treatment evolution and patient satisfaction. Aesthet Plast Surg. 2010;34(5):583–6.

    Article  Google Scholar 

  22. Nawrocki S, Cha J. Botulinum toxin: pharmacology and injectable administration for the treatment of primary hyperhidrosis. J Am Acad Dermatol. 2020;82(4):969–79.

    Article  CAS  PubMed  Google Scholar 

  23. Naumann M, Jankovic J. Safety of botulinum toxin type A: a systematic review and meta547 analysis. Curr Med Res Opin. 2004;20(7):981–90.

    Article  CAS  PubMed  Google Scholar 

  24. Dressler D, Hallett M. Immunological aspects of botox, dysport and myobloc/neurobloc. Eur J Neurol. 2006;13(1):11–5.

    Article  PubMed  Google Scholar 

  25. Atassi MZ. Basic immunological aspects of botulinum toxin therapy. Mov Disord. 2004;19(8):68–84.

    Article  Google Scholar 

  26. Dressler D, Dirnberger G, Bhatia KP, et al. Botulinum toxin antibody testing: comparison between the mouse protection assay and the mouse lethality assay. Mov Disord. 2000;15(5):973–6.

    Article  CAS  PubMed  Google Scholar 

  27. Liu MH, Beynet DP, Gharavi NM. Overview of deep dermal fillers. Facial Plast Surg. 2019;35(3):224–9.

    Article  CAS  PubMed  Google Scholar 

  28. Source: The Aesthetic Society. https://www.surgery.org/sites/default/files/2019-Trends.pdf.

  29. Rohrich RJ, Bartlett EL, Dayan E. Practical approach and safety of hyaluronic acid fillers. Plast Reconstr Surg Glob Open. 2019;7(6):e2172.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Stocks D, Sundaram H, Michaels J, et al. Rheological evaluation of the physical properties of hyaluronic acid dermal fillers. J Drugs Dermatol. 2011;10(9):974–80.

    CAS  PubMed  Google Scholar 

  31. Kablik J, Monheit GD, Yu L, et al. Comparative physical properties of hyaluronic acid dermal fillers. Dermatol Surg. 2009;35:302–12.

    Article  CAS  PubMed  Google Scholar 

  32. Lee JG, Yang HM, Hu KS, et al. Frontal branch of the superficial temporal artery: anatomical study and clinical implications regarding injectable treatments. Surg Radiol Anat. 2015;37(1):61–8.

    Article  PubMed  Google Scholar 

  33. Beleznay K, Carruthers JD, Humphrey S, Jones D. Avoiding and treating blindness from fillers: a review of the world literature. Dermatol Surg. 2015;41(10):1097–117.

    Article  CAS  PubMed  Google Scholar 

  34. Rohrich RJ, Pessa JE. The fat compartments of the face: anatomy and clinical implications for cosmetic surgery. Plast Reconstr Surg. 2007;119(7):2219–27.

    Article  CAS  PubMed  Google Scholar 

  35. Mendelson BC. Anatomic study of the retaining ligaments of the face and applications for facial rejuvenation. Aesthet Plast Surg. 2013;37(3):513–5.

    Article  Google Scholar 

  36. de Maio M, DeBoulle K, Braz A, et al. Facial assessment and injection guide for botulinum toxin and injectable hyaluronic acid fillers: focus on the midface. Alliance for the Future of Aesthetics Consensus Committee. Plast Reconstr Surg. 2017;140(4):540–50.

    Article  Google Scholar 

  37. Zimbler MS, Kokoska MS, Thomas JR. Anatomy and pathophysiology of facial aging. Facial Plast Surg Clin North Am. 2001;9(2):179–87.

    CAS  PubMed  Google Scholar 

  38. de Maio M, Wu WTL, Goodman GJ, Monheit G. Facial assessment and injection guide for botulinum toxin and injectable hyaluronic acid fillers: focus on the lower face. Plast Reconstr Surg. 2017;140(3):393–404.

    Article  Google Scholar 

  39. Vanaman Wilson MJ, Jones IT, et al. Role of nonsurgical chin augmentation in full face rejuvenation: a review and our experience. Dermatol Surg. 2018;44(7):985–93.

    Article  CAS  PubMed  Google Scholar 

  40. Kassir M, Gupta M, Galadari H, et al. Complications of botulinum toxin and fillers: a narrative review. J Cosmet Dermatol. 2020;19(3):570–3. https://doi.org/10.1111/jocd.13266.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Dermatology, Twacha Skin Clinic, New Delhi, India

    Richa Ojha Sharma

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  1. Richa Ojha Sharma
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Editors and Affiliations

  1. Department of Dermatology, Lady Hardinge Medical College and associated SSK and KSC Hospitals, Shaheed Bhagat Singh Marg, New Delhi, India

    Rashmi Sarkar

  2. Senior Specialist & Professor, Department of Dermatology, Venereology and Leprology Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) & Dr. Ram Manohar Lohia Hospital, New Delhi, India

    Surabhi Sinha

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Sharma, R.O. (2022). A Guide to Botulinum Toxin and Fillers. In: Sarkar, R., Sinha, S. (eds) Skin Diseases in Females. Springer, Singapore. https://doi.org/10.1007/978-981-16-6065-8_22

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  • DOI: https://doi.org/10.1007/978-981-16-6065-8_22

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-6064-1

  • Online ISBN: 978-981-16-6065-8

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