Abstract
The International Human Epigenome Consortium (IHEC) coordinates the creation of high-resolution reference epigenome maps for healthy and diseased human tissues. The IHEC Data Portal (http://epigenomesportal.ca/ihec) provides open access to discover, visualize, compare, and download annotation tracks generated for these reference epigenomes, along with their associated metadata. More than 16,000 transcriptome, methylome, and histone tracks, sourced from over 900 tissues and compared against the hg19 and hg38 reference genomes are provided. The standardized IHEC Data Hub submission protocol ensures that complete and compatible data is integrated from the consortium members. The data portal offers a highly visual, interactive, and intuitive data grid interface to facilitate dataset selection across multiple criteria. All data may be correlated, visualized in popular genome browsers, exported to a Galaxy instance, downloaded for further analysis, or saved as a session for future retrieval. Through providing access to IHEC’s database of reference epigenomic datasets, the IHEC Data Portal reinforces the consortium’s commitment to Open Science.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bujold D, de Lima Morais DA, Gauthier C, Côté C, Caron M, Kwan T, Chen KC, Laperle J, Markovits AN, Pastinen T, Caron B (2016) The international human epigenome consortium data portal. Cell Syst 3(5):496–499
Cell Ontology (2019). http://cellontology.org
Eilbeck K, Lewis SE, Mungall CJ, Yandell M, Stein L, Durbin R, Ashburner M (2005) The Sequence Ontology: a tool for the unification of genome annotations. Genome Biol 6:R44
Epigenome Reference Registry (2019). https://www.ebi.ac.uk/vg/epirr/
Giardine B, Riemer C, Hardison RC, Burhans R, Elnitski L, Shah P, Zhang Y, Blankenberg D, Albert I, Taylor J, Miller W (2005) Galaxy: a platform for interactive large-scale genome analysis. Genome Res 15(10):1451–1455
Global Alliance for Genomics and Health (2019). https://www.ga4gh.org/
Kent WJ, Zweig AS, Barber G, Hinrichs AS, Karolchik D (2010) BigWig and BigBed: enabling browsing of large distributed datasets. Bioinformatics 26(17):2204–2207
Laperle J, Hébert-Deschamps S, Raby J et al (2019) The epiGenomic Efficient Correlator (epiGeEC) tool allows fast comparison of user datasets with thousands of public epigenomic datasets. Bioinformatics 35(4):674–676. https://doi.org/10.1093/bioinformatics/bty655
Leinonen R, Akhtar R, Birney E, Bower L, Cerdeno-Tárraga A, Cheng Y, Cleland I, Faruque N, Goodgame N, Gibson R, Hoad G (2010) The European nucleotide archive. Nucleic Acids Res 39(Suppl 1):D28–D31
Malone J, Holloway E, Adamusiak T, Kapushesky M, Zheng J, Kolesnikov N, Zhukova A, Brazma A, Parkinson H (2010) Modeling sample variables with an experimental factor ontology. Bioinformatics 26(8):1112–1118
Mungall C, Haendel M, Dahdul W, Ibrahim N, Segerdell E, Blackburn D, Comte A, Niknejad A, Decechi A (2016) Uberon ontology. http://purl.obolibrary.org/obo/uberon/releases/2016-01-26/uberon.owl
NCI Metathesaurus (2019). https://ncim.nci.nih.gov/ncimbrowser/
Stunnenberg HG, Abrignani S, Adams D, de Almeida M, Altucci L, Amin V, Amit I, Antonarakis SE, Aparicio S, Arima T, Arrigoni L (2016) The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery. Cell 167(5):1145–1149
Tateno Y, Imanishi T, Miyazaki S, Fukami-Kobayashi K, Saitou N, Sugawara H, Gojobori T (2002) DNA Data Bank of Japan (DDBJ) for genome scale research in life science. Nucleic Acids Res 30(1):27–30
The Ontology for Biomedical Investigations (2016) PLoS One 11(4):e0154556. https://doi.org/10.1371/journal.pone.0154556. eCollection 2016
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Bujold, D., Grégoire, R., Brownlee, D., Zaytseva, K., Bourque, G. (2021). IHEC Data Portal. In: Abugessaisa, I., Kasukawa, T. (eds) Practical Guide to Life Science Databases. Springer, Singapore. https://doi.org/10.1007/978-981-16-5812-9_4
Download citation
DOI: https://doi.org/10.1007/978-981-16-5812-9_4
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-16-5811-2
Online ISBN: 978-981-16-5812-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)