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Relationship Between Probiotics and Gut-Skin Axis in Skin Wound Healing: A Recent Update

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Probiotic Research in Therapeutics

Abstract

There is an intricate relationship between human skin health and gut microenvironment, and both are equally influenced using probiotics. In recent years, there is growing evidence suggesting the role of probiotics in metabolism, immunomodulation, wound healing, and various inflammatory and infectious conditions. Both the skin and gut are morphologically different but share some common physiological features. The gut and skin interact mainly through this microbiota and the metabolites secreted by them that interfere with a cascade of biological pathways regulating metabolism, immunity, inflammation, oxidative stress, and neuroendocrine function. Understanding the mechanism of action by which gut influences skin health (inside-out) is essential to define the cross talk between the two compartments. Probiotics can be exploited as modern therapeutics or as an adjuvant to classical therapies in the management of a variety of human diseases. However, limited data is available on the clinical potential of oral and topical probiotics in the treatment of skin- and gut-associated diseases. Although probiotics are considered safe, a comprehensive investigation is also required to establish the safety measures in immunocompromised persons. The present review highlighted the significance of probiotics in the gut-skin axis with a special reference to gut microbiota, skin homeostasis, and skin wound healing.

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Acknowledgments

We acknowledge the support provided by the grant from the United States Department of Defense (SC160029).

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The authors declare no conflict of interest, financial or otherwise.

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Author notes

  1. Manoj Kumar Tembhre, Mehma Kaur Chawla and Suneel Kumar contributed equally with all other contributors.

Authors and Affiliations

  1. Department of Cardiac Biochemistry, Cardio-Thoracic Sciences Centre, All India Institute of Medical Sciences, New Delhi, India

    Manoj Kumar Tembhre

  2. Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA

    Mehma Kaur Chawla, Francois Berthiaume & Suneel Kumar

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  1. Manoj Kumar Tembhre
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Correspondence to Suneel Kumar .

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Editors and Affiliations

  1. Center for Dermal Research (CDR) and Laboratory for Drug Delivery (LDD), Rutgers-The State University of New Jersey, Piscataway, NJ, USA

    Kavita Beri

  2. G.H.G. Khalsa College of Pharmacy, Gurusar Sadhar, Ludhiana, Punjab, India

    Parneet Kaur Deol

  3. Taro Pharmaceutical Industries Limited, Brampton, ON, Canada

    Simarjot Kaur Sandhu

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Tembhre, M.K., Chawla, M.K., Berthiaume, F., Kumar, S. (2022). Relationship Between Probiotics and Gut-Skin Axis in Skin Wound Healing: A Recent Update. In: Beri, K., Deol, P.K., Sandhu, S.K. (eds) Probiotic Research in Therapeutics. Springer, Singapore. https://doi.org/10.1007/978-981-16-5628-6_8

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