Functional Correlation Between ROS and Cancer Stem Cells in Cancer Progression

Vishnupriya, P.; Aparna, A.; Vijaya Padma, V.

doi:10.1007/978-981-16-5422-0_89

P. Vishnupriya²^na1,
A. Aparna²^na1 &
V. Vijaya Padma²^na1

22 Accesses

Abstract

Reactive oxygen species (ROS) are extremely active molecules which are primarily consequential to aerobic metabolism. They serve as a “double-edged sword” by playing a regulatory role in both promotion and suppression of tumor. Cancer cells maintain a state of high ROS levels, whereas cancer stem cells (CSCs) survive in low ROS level which is crucial to maintain the self-renewal and stemness. Tumor hypoxia in CSCs is known for its significant role in EMT which may lead to cancer progression. Surprisingly, the generation of cells having stem cell properties is possible through EMT signaling. Interdependence of hypoxia, ROS production, EMT, and CSCs has been posited in the retrospective literature. CSCs are characterized by unique properties such as resistance to radio- and chemotherapy when compared to non-CSCs. The observation of CSCs holding enhanced protection mechanism from ROS-induced stress and a different metabolism from the differentiated part of the tumor has opened up a novel avenue in research, and it started developing drugs targeting CSC-specific signaling. Hence, the strategies that could increase the ROS and oxidative stress in CSCs might assist in eradication of these parent cells and a comprehensive picture about the CSC niche, and decoding the mechanisms of redox regulation in CSCs could lead to the discovery of therapeutic approaches for cancer. The chapter summarizes the role of ROS-induced tumor angiogenesis, metastasis and inflammation, ROS in the maintenance of CSCs, CSCs in EMT, and therapeutic targeting of CSCs.

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P. Vishnupriya and A. Aparna contributed equally with all other contributors.

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Translational Research Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, Tamil Nadu, India
P. Vishnupriya, A. Aparna & V. Vijaya Padma

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P. Vishnupriya
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A. Aparna
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V. Vijaya Padma
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Correspondence to V. Vijaya Padma .

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Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India
Sajal Chakraborti

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Cellular Stress and Immune Response Laboratory, Centre for Cancer Biology, University of South Australia, Adelaide, South Australia, Australia
Nirmal Robinson
Department of Morphofunctional Sciences, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania
Cornelia Amalinei
Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana State, India
Amitava Das
Biological Sciences, Academy of Scientific and Innovative Research, Ghaziabad,, UP, India
Amitava Das
Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Chennai, Tamil Nadu, India
Surajit Pathak
Stem Cell Facility, DBT-Centre of Excellence for Stem Cell Research, All India Institute of Medical Sciences, New Delhi, India
Sujata Mohanty

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Vishnupriya, P., Aparna, A., Vijaya Padma, V. (2022). Functional Correlation Between ROS and Cancer Stem Cells in Cancer Progression. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_89

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DOI: https://doi.org/10.1007/978-981-16-5422-0_89
Published: 29 September 2022
Publisher Name: Springer, Singapore
Print ISBN: 978-981-16-5421-3
Online ISBN: 978-981-16-5422-0
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences

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