Therapeutic Potential of Natural Agents Against Oxidative Stress-Influenced Colitis-Associated Cancer

Venkatesan, Aarthy; Sadik, Saabira Banu Sahubar; Sivaprakasam, Prathibha; A. Adil, Mohamed; Chandrabose, Karthikeyan; Anandasadagopan, Suresh Kumar; Pandurangan, Ashok Kumar

doi:10.1007/978-981-16-5422-0_8

Aarthy Venkatesan²,
Saabira Banu Sahubar Sadik²,
Prathibha Sivaprakasam²,
Mohamed A. Adil³,
Karthikeyan Chandrabose⁴,
Suresh Kumar Anandasadagopan⁵ &
…
Ashok Kumar Pandurangan²

37 Accesses

Abstract

The association among inflammation, oxidative stress, and cancer is an established epidemiological data. Oxidative stress is responsible for the production of ROS (reactive oxygen species) and for the diminishing of the antioxidant resistance system. ROS are highly generated by the immune system products as a result of inflammatory reactions. The oxidative stress generated in an inflamed tissue with non-infective cause is a major risk factor for the result of development of different types of malignant cancer. Untreated chronic inflammation in the colon may lead to colitis-associated cancer (CAC) which is a type of colorectal cancer (CRC). It is the characterization of the inflammation of the large bowel (IBD – inflammatory bowel diseases). There are many works with proven data demonstrating that inflammation, oxidative stress, and cancer are closely associated. Here, the mechanism of oxidative stress in causing CAC, sources of the free radicals, various pathways affected by ROS leading to tumor progression, and antioxidant defense mechanisms are focused.

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School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Chennai, India
Aarthy Venkatesan, Saabira Banu Sahubar Sadik, Prathibha Sivaprakasam & Ashok Kumar Pandurangan
School of Allied Health Sciences, Meenakshi Academy of Higher Education and Research (MAHER), Chennai, India
Mohamed A. Adil
School of Allied Health Sciences, Meenakshi Academy of Higher Education and Research (MAHER), Bhopal, India
Karthikeyan Chandrabose
Department of Biochemistry and Biotechnology Lab, CSIR-Central Leather Research Institute, Chennai, India
Suresh Kumar Anandasadagopan

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Aarthy Venkatesan
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Saabira Banu Sahubar Sadik
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Prathibha Sivaprakasam
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Mohamed A. Adil
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Karthikeyan Chandrabose
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Suresh Kumar Anandasadagopan
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Ashok Kumar Pandurangan
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Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India
Sajal Chakraborti

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Department of Internal Medicine, General Hospital Minamiseiko Hospital, Nagoya, Japan
Takehiko Takayanagi
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA
Prakash Radhakrishnan
Department of Nutrition and Dietetics, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey
Ayse Günes-Bayir
Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, Illinois, USA
Gnanasekar Munirathinam
Dean, Research, Central University of Punjab, Bathinda, Punjab, India
Anjana Munsi

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Venkatesan, A. et al. (2022). Therapeutic Potential of Natural Agents Against Oxidative Stress-Influenced Colitis-Associated Cancer. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_8

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