Skip to main content
SpringerLink
Log in

Evaluation of the Anticancer Activities of Isatin-Based Derivatives

  • Reference work entry
  • First Online:
Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

Abstract

Isatin-based derivatives are important organic molecules that use isatin (1H-indole-2,3-dione) as a backbone/scaffold; manipulation of key groups on the isatin backbone allows for synthesis of a wide range of derivatives of different classes which possess varied biological effects. These compounds have been found to act as ligands/antagonists of key receptors which regulate cancer signal transduction and metabolism in different cancer types. During thorough literature survey, we stumbled upon potent anticancer isatin derivatives of different kinds. These compounds have been synthesized, purified, characterized (using a range of biophysical techniques), and explored for prospective anticancer activity with the aid of in silico, in vitro, and in vivo methodologies. This chapter presents some of the representative anticancer isatin derivatives with potent anticancer activities. Since isatin is a naturally occurring compound in both plants and animals, utilization of this backbone for substitution reactions yields diverse pharmacophores with low toxicity and higher affinity for key cancer target receptors. Hence, these molecules may be safer for human chemotherapeutic interventions when compared to some routinely used anticancer chemotherapeutic agents which are organometallic complexes like cisplatin. A review of isatin-based derivatives is presented, and an attempt is made to encapsulate the rich structural and functional diversities of a few biologically active (and particularly, anticancer and redox active) isatin derivatives which may have potential to clear clinical trials and develop into standard chemotherapeutic agents.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Abbreviations

Akt:

Serine/Threonine protein kinase (Protein Kinase B)

BAX:

BCL-2 Associated X Apoptosis Receptor

BCL-2:

B-cell Lymphoma 2

CDK 1/CDK2:

Cyclin-Dependent Kinase 1 or 2

CLK:

CDC2-Like Kinase

EGFR:

Epidermal Growth Factor Receptor

EPR:

Electron Paramagnetic Resonance

ERB:

Estrogen Receptor Beta

FITC:

Fluorescein isothiocyanate

FTIR:

Fourier Transform Infrared Spectroscopy

GSK3β:

Glycogen Synthase Kinase3

HGF:

Hepatocyte growth factor

HRMS:

High-Resolution Mass Spectroscopy

IBD:

Isatin-Based derivatives

JAK/STAT:

Janus Kinase/Signal Transducer and Activity of Transcription

JNK3:

c- Jun NH2 Terminal Kinase

MAPK:

Mitogen-Activated Protein Kinase

MDR:

Multiple Drug Resistance

mTOR:

Mechanistic Target of Rapamycin

OxPhos:

Oxidative Phosphorylation

PDGFR:

Platelet-Derived Growth Factor Receptor

PI3K:

Phosphoinositide 3-Kinase

QSAR:

Quantitative Structure Activity Relationship

RCS:

Reactive Carbon Species

RHS:

Reactive Halogen Species

RNS:

Reactive Nitrogen Species

ROS:

Reactive Oxygen Species

RSS:

Reactive Sulphur Species

RTK:

Receptor Tyrosine Kinase

SRC:

Proto-Oncogene Tyrosine Protein Kinase

References

  • Abo-Salem HM, Nassrallah A, Soliman AA, Ebied MS, Elawady ME, Abdelhamid SA, El-Sawy ER, Al-Sheikh YA, Aboul-Soud MA (2020) Synthesis and bioactivity assessment of novel spiro pyrazole-oxindole congeners exhibiting potent and selective in vitro anticancer effects. Molecules 25(5):1124

    CAS  Google Scholar 

  • Ali AQ, Teoh SG, Eltayeb NE, Ahamed MBK, Majid AA (2014a) Synthesis of copper (II) complexes of isatin thiosemicarbazone derivatives: in vitro anti-cancer, DNA binding, and cleavage activities. Polyhedron 74:6–15

    CAS  Google Scholar 

  • Ali AQ, Teoh SG, Eltayeb NE, Ahamed MBK, Majid AA (2014b) Synthesis of nickel (II) complexes of isatin thiosemicarbazone derivatives: in vitro anti-cancer, DNA binding, and cleavage activities. J Coord Chem 67(20):3380–3400

    CAS  Google Scholar 

  • Al-Salem HS, Arifuzzaman M, Issa IS, Rahman A (2021) Isatin-hydrazones with multiple Receptor Tyrosine Kinases (RTKs) inhibitory activity and in-silico binding mechanism. Appl Sci 11(9):3746

    CAS  Google Scholar 

  • Ammar YA, Fayed EA, Bayoumi AH, Ezz RR, Alsaid MS, Soliman AM, Ghorab MM (2017) New chalcones bearing isatin scaffold: synthesis, molecular modeling and biological evaluation as anticancer agents. Res Chem Intermed 43(12):6765–6786

    CAS  Google Scholar 

  • Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Varoli L, Cremonini MA, Placucci G (2010) New isatin derivatives with antioxidant activity. Eur J Med Chem 45(4):1374–1378

    CAS  Google Scholar 

  • Aneja B, Khan NS, Khan P, Queen A, Hussain A, Rehman MT, Alajmi MF, El-Seedi HR, Ali S, Hassan MI (2019) Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis. Eur J Med Chem 163:840–852

    CAS  Google Scholar 

  • Aruoma OI, Murcia A, Butler J, Halliwell B (1993) Evaluation of the antioxidant and prooxidant actions of gallic acid and its derivatives. J Agric Food Chem 41(11):1880–1885

    CAS  Google Scholar 

  • Badavath VN, Kumar A, Samanta PK, Maji S, Das A, Blum G, Jha A, Sen A (2020) Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (mpro): A molecular docking, molecular dynamics and structure-activity relationship studies. J Biomol Struct Dyn:1–19

    Google Scholar 

  • Balachandran C, Haribabu J, Jeyalakshmi K, Bhuvanesh NS, Karvembu R, Emi N, Awale S (2018) Nickel (II) bis (isatin thiosemicarbazone) complexes induced apoptosis through mitochondrial signaling pathway and G0/G1 cell cycle arrest in IM-9 cells. J Inorg Biochem 182:208–221

    CAS  Google Scholar 

  • Britto KB, Francisco CS, Ferreira D, Borges BJ, Conti R, Profeti D, Rodrigues LR, Lacerda V, Morais PA, Borges WS (2020) Identifying new Isatin derivatives with GSK-3β inhibition capacity through molecular docking and bioassays. J Braz Chem Soc 31:476–487

    CAS  Google Scholar 

  • Cao J, Gao H, Bemis G, Salituro F, Ledeboer M, Harrington E, Wilke S, Taslimi P, Pazhanisamy S, Xie X (2009) Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors. Bioorg Med Chem Lett 19(10):2891–2895

    CAS  Google Scholar 

  • Chandran VI, Matesic L, Locke JM, Skropeta D, Ranson M, Vine KL (2012) Anti-cancer activity of an acid-labile N-alkyl isatin conjugate targeting the transferrin receptor. Cancer Lett 316(2):151–156

    CAS  Google Scholar 

  • Chen G, Wang Y, Hao X, Mu S, Sun Q (2011) Simple isatin derivatives as free radical scavengers: synthesis, biological evaluation and structure-activity relationship. Chem Cent J 5(1):1–5

    CAS  Google Scholar 

  • Circu ML, Aw TY (2010) Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 48(6):749–762

    CAS  Google Scholar 

  • Dao VT-V, Casas AI, Maghzal GJ, Seredenina T, Kaludercic N, Robledinos-Anton N, Di Lisa F, Stocker R, Ghezzi P, Jaquet V (2015) Pharmacology and clinical drug candidates in redox medicine. Antioxid Redox Signal 23(14):1113–1129

    CAS  Google Scholar 

  • de Paiva REF, Vieira EG, da Silva DR, Wegermann CA, Ferreira AMC (2020) Anticancer compounds based on isatin-derivatives: strategies to ameliorate selectivity and efficiency. Front Mol Biosci 7

    Google Scholar 

  • Ding Y, Zhao L, Fu Y, Hao L, Fu Y, Yuan Y, Yu P, Teng Y (2021) Synthesis and antiproliferatory activities evaluation of multi-substituted Isatin derivatives. Molecules 26(1):176

    CAS  Google Scholar 

  • El-Azab AS, Al-Dhfyan A, Abdel-Aziz AA-M, Abou-Zeid LA, Alkahtani HM, Al-Obaid AM, Al-Gendy MA (2017) Synthesis, anticancer and apoptosis-inducing activities of quinazoline–isatin conjugates: epidermal growth factor receptor-tyrosine kinase assay and molecular docking studies. J Enzyme Inhib Med Chem 32(1):935–944

    CAS  Google Scholar 

  • Eldehna WM, Altoukhy A, Mahrous H, Abdel-Aziz HA (2015) Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents. Eur J Med Chem 90:684–694

    CAS  Google Scholar 

  • Eldehna WM, Abo-Ashour MF, Nocentini A, El-Haggar RS, Bua S, Bonardi A, Al-Rashood ST, Hassan GS, Gratteri P, Abdel-Aziz HA (2019) Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents. Eur J Med Chem 162:147–160

    CAS  Google Scholar 

  • Eldehna WM, Salem R, Elsayed ZM, Al-Warhi T, Knany HR, Ayyad RR, Traiki TB, Abdulla M-H, Ahmad R, Abdel-Aziz HA (2021) Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer. J Enzyme Inhib Med Chem 36(1):1424–1435

    Google Scholar 

  • Fares M, Eldehna WM, Abou-Seri SM, Abdel-Aziz HA, Aly MH, Tolba MF (2015) Design, synthesis and in vitro antiproliferative activity of novel isatin-quinazoline hybrids. Arch Pharm 348(2):144–154

    CAS  Google Scholar 

  • Fayed EA, Eldin RRE, Mehany A, Bayoumi AH, Ammar YA (2021) Isatin-Schiff’s base and chalcone hybrids as chemically apoptotic inducers and EGFR inhibitors; design, synthesis, anti-proliferative activities and in silico evaluation. J Mol Struct 1234:130159

    CAS  Google Scholar 

  • Filomeni G, Cerchiaro G, Ferreira AMDC, De Martino A, Pedersen JZ, Rotilio G, Ciriolo MR (2007) Pro-apoptotic activity of novel Isatin-Schiff base copper (II) complexes depends on oxidative stress induction and organelle-selective damage. J Biol Chem 282(16):12010–12021

    CAS  Google Scholar 

  • Gangarapu K, Thumma G, Manda S, Jallapally A, Jarapula R, Rekulapally S (2017) Design, synthesis and molecular docking of novel structural hybrids of substituted isatin based pyrazoline and thiadiazoline as antitumor agents. Med Chem Res 26(4):819–829

    CAS  Google Scholar 

  • Guo H, Diao Q-P (2020) The anti-breast cancer potential of Bis-Isatin scaffolds. Curr Top Med Chem 20(16):1499–1503

    CAS  Google Scholar 

  • Gupta AK, Tulsyan S, Bharadwaj M, Mehrotra R (2019) Systematic review on cytotoxic and anticancer potential of n-substituted isatins as novel class of compounds useful in multidrug-resistant cancer therapy: in silico and in vitro analysis. Top Curr Chem 377(3):15

    Google Scholar 

  • Hasinoff BB (2010) The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity. Toxicol Appl Pharmacol 244(2):190–195

    CAS  Google Scholar 

  • Hasinoff BB, Patel D (2010) The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro. Toxicol Appl Pharmacol 249(2):132–139

    CAS  Google Scholar 

  • Jeding I, Evans PJ, Akanmu D, Dexter D, Spencer JD, Aruoma OI, Jenner P, Halliwell B (1995) Characterization of the potential antioxidant and pro-oxidant actions of some neuroleptic drugs. Biochem Pharmacol 49(3):359–365

    CAS  Google Scholar 

  • Kakkar R (2019) Isatin and its derivatives: a survey of recent syntheses, reactions, and applications. MedChemComm 10(3):351–368

    Google Scholar 

  • Kalyanaraman B, Perez-Reyes E, Mason RP (1980) Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs. Biochim Biophys Acta (BBA) 630(1):119–130

    CAS  Google Scholar 

  • Karthikeyan C, Solomon VR, Lee H, Trivedi P (2013) Design, synthesis and biological evaluation of some isatin-linked chalcones as novel anti-breast cancer agents: a molecular hybridization approach. Biomed Prev Nutr 3(4):325–330

    Google Scholar 

  • Ke S, Shi L, Yang Z (2015) Discovery of novel isatin–dehydroepiandrosterone conjugates as potential anticancer agents. Bioorg Med Chem Lett 25(20):4628–4631

    CAS  Google Scholar 

  • Khaldoun K, Safer A, Boukabcha N, Dege N, Ruchaud S, Souab M, Bach S, Chouaih A, Saidi-Besbes S (2019) Synthesis and evaluation of new isatin-aminorhodanine hybrids as PIM1 and CLK1 kinase inhibitors. J Mol Struct 1192:82–90

    CAS  Google Scholar 

  • Kohanski MA, Dwyer DJ, Hayete B, Lawrence CA, Collins JJ (2007) A common mechanism of cellular death induced by bactericidal antibiotics. Cell 130(5):797–810

    CAS  Google Scholar 

  • Kumar MR, Manikandan A, Sivakumar A, Dhayabaran VV (2018a) An eco-friendly catalytic system for multicomponent, one-pot synthesis of novel spiro-chromeno indoline-triones and their anti-prostate cancer potentials evaluated via alkaline phosphatase inhibition mechanism. Bioorg Chem 81:44–54

    CAS  Google Scholar 

  • Kumar MR, Alagumuthu M, Dhayabaran VV (2018b) N-substituted hydroxynaphthalene imino-oxindole derivatives as new class of PI 3-kinase inhibitor and breast cancer drug: molecular validation and structure–activity relationship studies. Chem Biol Drug Des 91(1):277–284

    Google Scholar 

  • Kumar MR, Dhayabaran VV, Sudhapriya N, Manikandan A, Gideon DA, Annapoorani S (2020) p-TSA. H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer. Bioorg Chem 102:104046

    Google Scholar 

  • Kumar R, Gideon DA, Mariadasse R, Nirusimhan V, Castin J, Jeyakanthan J, Dhayabaran VV (2021) In silico evaluation of isatin-based derivatives with RNA-dependent RNA polymerase of the novel coronavirus SARS-CoV-2

    Google Scholar 

  • Levy M, Courtney CM, Chowdhury PP, Ding Y, Grey EL, Goodman SM, Chatterjee A, Nagpal P (2018) Assessing different reactive oxygen species as potential antibiotics: selectivity of intracellular superoxide generation using quantum dots. ACS Appl Bio Mater 1(2):529–537

    CAS  Google Scholar 

  • Liang Z, Zhang D, Ai J, Chen L, Wang H, Kong X, Zheng M, Liu H, Luo C, Geng M (2011) Identification and synthesis of N′-(2-oxoindolin-3-ylidene) hydrazide derivatives against c-met kinase. Bioorg Med Chem Lett 21(12):3749–3754

    CAS  Google Scholar 

  • Lotfy G, Said MM, El Sayed H, El Sayed H, Al-Dhfyan A, Aziz YMA, Barakat A (2017) Synthesis of new spirooxindole-pyrrolothiazole derivatives: anti-cancer activity and molecular docking. Bioorg Med Chem 25(4):1514–1523

    CAS  Google Scholar 

  • Maadwar S, Galla R (2019) Cytotoxic oxindole derivatives: in vitro EGFR inhibition, pharmacophore modeling, 3D-QSAR and molecular dynamics studies. J Recept Sig Transd 39(5–6):460–469

    CAS  Google Scholar 

  • Mahapatra DK, Bharti SK, Asati V (2015) Anti-cancer chalcones: structural and molecular target perspectives. Eur J Med Chem 98:69–114

    CAS  Google Scholar 

  • Manoj KM (2020) Murburn concept: a paradigm shift in cellular metabolism and physiology. Biomol Concepts 11(1):7–22

    CAS  Google Scholar 

  • Manoj KM, Parashar A, Venkatachalam A, Goyal S, Singh PG, Gade SK, Periyasami K, Jacob RS, Sardar D, Singh S (2016) Atypical profiles and modulations of heme-enzymes catalyzed outcomes by low amounts of diverse additives suggest diffusible radicals’ obligatory involvement in such redox reactions. Biochimie 125:91–111

    CAS  Google Scholar 

  • Manoj KM, Soman V, Jacob VD, Parashar A, Gideon DA, Kumar M, Manekkathodi A, Ramasamy S, Pakshirajan K, Bazhin NM (2019) Chemiosmotic and murburn explanations for aerobic respiration: predictive capabilities, structure-function correlations and chemico-physical logic. Arch Biochem Biophys 676:108128

    CAS  Google Scholar 

  • Marengo B, Nitti M, Furfaro AL, Colla R, Ciucis CD, Marinari UM, Pronzato MA, Traverso N, Domenicotti C (2016) Redox homeostasis and cellular antioxidant systems: crucial players in cancer growth and therapy. Oxidative Med Cell Longev 2016

    Google Scholar 

  • Matesic L, Locke JM, Vine KL, Ranson M, Bremner JB, Skropeta D (2011) Synthesis and hydrolytic evaluation of acid-labile imine-linked cytotoxic isatin model systems. Bioorg Med Chem 19(5):1771–1778

    CAS  Google Scholar 

  • McDonald PC, Winum J-Y, Supuran CT, Dedhar S (2012) Recent developments in targeting carbonic anhydrase IX for cancer therapeutics. Oncotarget 3(1):84

    Google Scholar 

  • Medvedev AE, Clow A, Sandler M, Glover V (1996) Isatin: a link between natriuretic peptides and monoamines? Biochem Pharmacol 52(3):385–391

    CAS  Google Scholar 

  • Medvedev A, Buneeva O, Glover V (2007) Biological targets for isatin and its analogues: implications for therapy. Biolog Targets Ther 1(2):151

    CAS  Google Scholar 

  • Medvedev A, Buneeva O, Gnedenko O, Ershov P, Ivanov A (2018) Isatin, an endogenous nonpeptide biofactor: a review of its molecular targets, mechanisms of actions, and their biomedical implications. Biofactors 44(2):95–108

    CAS  Google Scholar 

  • Nath R, Pathania S, Grover G, Akhtar MJ (2020) Isatin containing heterocycles for different biological activities: analysis of structure activity relationship. J Mol Struct:128900

    Google Scholar 

  • Premanathan M, Radhakrishnan S, Kulangiappar K, Singaravelu G, Thirumalaiarasu V, Sivakumar T, Kathiresan K (2012) Antioxidant & anticancer activities of isatin (1H-indole-2, 3-dione), isolated from the flowers of Couroupita guianensis Aubl. Indian J Med Res 136(5):822

    CAS  Google Scholar 

  • Rodrı̀guez-Argüelles MC, Ferrari MB, Bisceglie F, Pelizzi C, Pelosi G, Pinelli S, Sassi M (2004) Synthesis, characterization and biological activity of Ni, Cu and Zn complexes of isatin hydrazones. J Inorg Biochem 98(2):313–321

    Google Scholar 

  • Shuhendler AJ, Pu K, Cui L, Uetrecht JP, Rao J (2014) Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing. Nat Biotechnol 32(4):373–380

    CAS  Google Scholar 

  • Sun J, Liu B, Xu B (2013) Copper-catalyzed tandem oxidative cyclization of arylacetamides: efficient access to N-functionalized isatins. RSC Adv 3(17):5824–5827

    CAS  Google Scholar 

  • Tahermansouri H, Chitgar F (2013) Synthesis of isatin derivative on the short multiwalled carbon nanotubes and their effect on the mkn-45 and sw742 cancer cells. J Chem 2013

    Google Scholar 

  • Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39(1):44–84

    CAS  Google Scholar 

  • Verma M, Pandeya SN, Singh KN, Stables JP (2004) Anticonvulsant activity of Schiff bases of isatin derivatives. Acta Pharma 54(1):49–56

    CAS  Google Scholar 

  • Vine KL, Belfiore L, Jones L, Locke JM, Wade S, Minaei E, Ranson M (2016) N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines. Heliyon 2(1):e00060

    Google Scholar 

  • Wondrak GT (2009) Redox-directed cancer therapeutics: molecular mechanisms and opportunities. Antioxid Redox Signal 11(12):3013–3069

    CAS  Google Scholar 

  • Xu Z, Zhao S-J, Lv Z-S, Gao F, Wang Y, Zhang F, Bai L, Deng J-L (2019) Fluoroquinolone-isatin hybrids and their biological activities. Eur J Med Chem 162:396–406

    CAS  Google Scholar 

  • Yousef MA, Ali AM, El-Sayed WM, Quayed WS, Farag HH, Aboul-Fadl T (2020) Design and synthesis of novel isatin-based derivatives targeting cell cycle checkpoint pathways as potential anticancer agents. Bioorg Chem 105:104366

    CAS  Google Scholar 

  • Yu B, Yu D-Q, Liu H-M (2015) Spirooxindoles: promising scaffolds for anticancer agents. Eur J Med Chem 97:673–698

    CAS  Google Scholar 

  • Zhang YZ, Du HZ, Liu HL, He QS, Xu Z (2020) Isatin dimers and their biological activities. Arch Pharm 353(3):1900299

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biotechnology and Bioinformatics, Bishop Heber College (Autonomous), Affiliated to Bharathidasan University, Tiruchirappalli, Tamil Nadu, India

    Daniel A. Gideon

  2. Periyar EVR College (Autonomous), Tiruchirappalli, India

    Pushparaj Annadurai

  3. Department of Bioinformatics, Alagappa University, Karaikudi, India

    Vijay Nirusimhan

  4. Department of Biotechnology, Vignan’s Foundation for Science, Technology and Research, Guntur, India

    Abhinav Parashar

  5. Department of Medicine, Department of Physiology, University of Arizona, Tucson, AZ, USA

    Joel James

  6. Scintelligent Biotechnology Solutions, Tiruchirappalli, Tamil Nadu, India

    Daniel A. Gideon

  7. Department of Biotechnology and Bioinformatics, Bishop Heber College (Autonomous), Tiruchirappalli, India

    V. Violet Dhayabaran

  8. Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine, Tucson, AZ, USA

    Joel James

Authors
  1. Daniel A. Gideon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pushparaj Annadurai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Vijay Nirusimhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Abhinav Parashar
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Joel James
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. Violet Dhayabaran
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. The Gurdon Institute, University of Cambridge, Cambridge, UK

    Jan Jezek

  2. Department of Pharmaceutical Sciences, St. John's University, Queens, NY, USA

    Zhe-Sheng Chen

  3. Department of Physiology, University of Arizona, Tucson, Arizona, USA

    Amritlal Mandal

  4. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Jishu Naskar

  5. Department of Veterinary Clinical Complex (V.M.E.J.), West Bengal University of Animal & Fishery Sciences, Kolkata, West Bengal, India

    Tanmoy Rana

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Singapore Pte Ltd.

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Gideon, D.A., Annadurai, P., Nirusimhan, V., Parashar, A., James, J., Dhayabaran, V.V. (2022). Evaluation of the Anticancer Activities of Isatin-Based Derivatives. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_51

Download citation

Publish with us

Policies and ethics

Search

Navigation