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Application of Stimuli-Responsive Polymers in Cancer Therapy

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Stimuli-responsive drug delivery systems used in cancer therapy based on stimuli-responsive polymers are having advantage over conventional chemotherapeutic agents with very less side effects, high concentration at tumor site, and improved efficiency in the treatment of cancer. Cancer chemotherapy have a lot of disadvantages such as systemic toxicity, non-specificity, low concentration in tumor site, and ubiquitous biodistribution. At the time of cancer treatment, multiple changes occur in different body parts simultaneously. To mimic such changes in biological processes, stimuli-responsive polymers are required to sense and respond toward these changes in a particular manner. Stimuli-responsive polymers have property to mimic and recognize changes of biological processes for targeting the specific cancer cells. In continuation of this, stimuli-responsive polymers act at site either simultaneously or in a step-by-step manner to initiate the drug from its very first step to reach the cancer cell. In last decades, polymers are extremely use in target specific drug delivery to inactivate or kill cancerous cells. In continuation of this, a number of endogenous stimuli-responsive polymers (redox-, pH-, enzyme-responsive polymers) and exogenous stimuli-responsive polymers (temperature, light) proved helpful in drug delivery. The present chapter depicts about the stimuli-responsive polymers as well as multi-responsive polymers and their significant role with respect to drug delivery system in the treatment of cancer.

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Author information

Authors and Affiliations

  1. Department of Zoology, Chaudhary Bansi lal University, Bhiwani, Haryana, India

    Parvati Sharma & Asha Poonia

  2. Department of Zoology, Research Scholar, Chaudhary Bansi lal University, Bhiwani, Haryana, India

    Monika Jangra &  Ankur

Authors
  1. Parvati Sharma
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  2. Asha Poonia
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  3. Monika Jangra
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  4. Ankur
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Editor information

Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. The Gurdon Institute, University of Cambridge, Cambridge, UK

    Jan Jezek

  2. Department of Pharmaceutical Sciences, St. John's University, Queens, NY, USA

    Zhe-Sheng Chen

  3. Department of Physiology, University of Arizona, Tucson, Arizona, USA

    Amritlal Mandal

  4. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Jishu Naskar

  5. Department of Veterinary Clinical Complex (V.M.E.J.), West Bengal University of Animal & Fishery Sciences, Kolkata, West Bengal, India

    Tanmoy Rana

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Sharma, P., Poonia, A., Jangra, M., Ankur (2022). Application of Stimuli-Responsive Polymers in Cancer Therapy. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_50

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