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Natural Chemopreventive Agents for the Treatment and Prevention of Oral Squamous Cell Carcinoma

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Oral cancer is a severe health problem claiming around 120,000 deaths annually, of which 90% is oral squamous cell carcinoma (OSCC). Despite the development of various chemical drugs, the overall survival rate remains limited. Further, resistances to the standard chemotherapeutic drugs and targeted therapy amounts to severe challenges in the treatment and prevention of OSCC. Hence, the development of novel anticancer drugs with minimum adverse effects would aid in to circumvent this current scenario. In fact, the interrelation between healthy diet and reduced prevalence of cancer opened up a new arena for researchers to explore phytochemicals to complement current cancer therapies. Surprisingly, these plant-derived natural compounds exert their beneficial effects through the regulation of various molecular pathways, such as cellular proliferation, invasion and metastasis through exerting its antioxidant activity, apoptosis, cell cycle arrest, and inactivation of carcinogen. In this review, we are focusing on various phytochemicals that have shown to have chemopreventive activity against OSCC and their pharmacological activity corresponding to their molecular targets.

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Authors and Affiliations

  1. Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India

    Viji Remadevi, Juberiya M. Azeez, Vini Ravindran, Sreeharshan Sreeja & Anjana Sasikumar Sujatha

  2. Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA

    Saifudeen Ismael

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  1. Viji Remadevi
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  2. Juberiya M. Azeez
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  3. Vini Ravindran
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  4. Sreeharshan Sreeja
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  5. Anjana Sasikumar Sujatha
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  6. Saifudeen Ismael
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Editor information

Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Department of Internal Medicine, General Hospital Minamiseiko Hospital, Nagoya, Japan

    Takehiko Takayanagi

  2. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA

    Prakash Radhakrishnan

  3. Department of Nutrition and Dietetics, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey

    Ayse Günes-Bayir

  4. Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, Illinois, USA

    Gnanasekar Munirathinam

  5. Dean, Research, Central University of Punjab, Bathinda, Punjab, India

    Anjana Munsi

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Remadevi, V., Azeez, J.M., Ravindran, V., Sreeja, S., Sujatha, A.S., Ismael, S. (2022). Natural Chemopreventive Agents for the Treatment and Prevention of Oral Squamous Cell Carcinoma. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_207

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