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Zebrafish: A Potential Preclinical Model for Neurological Research in Modern Biology

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Zebrafish Model for Biomedical Research

Abstract

Zebrafish have recently acquired the attention of the research community as a model to study neurological pathologies and behavioural anomalies. The small size and high fecundity have made the zebrafish highly suitable for high-throughput screening. The relatively simple organisation of its nervous system and the optically transparent embryos allow real-time neurological imaging of the zebrafish embryos. Further, genetic malleability and highly varied behavioural repertoire increase its suitability as a model for neurological studies. The recent increase in ageing population and the number of patients suffering with neurodegeneration pose the pressing need for effective models for the study of neurological diseases. The current dearth of therapies for the treatment of neurological disorders is mainly due to the lack of absolute and robust in vivo models. Interestingly, zebrafish models have been found to successfully simulate Alzheimer’s disease (AD) and tauopathy pathologies along with other neurodegenerative conditions. This chapter summarizes the contemporary research studies that employ zebrafish as neurological models for the development of improved translational therapeutic strategies.

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Acknowledgement

The authors acknowledge the financial support from the DBT-RA Program in Biotechnology and Life Sciences and DBT-Nanobiotechnology Program (San. No. BT/PR6765/NNT/28/618/2012), Government of India.

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  1. Neuroscience Lab, Centre for Molecular and Nanomedical Sciences, Centre for Nanoscience and Nanotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, (Deemed to be University), Chennai, Tamil Nadu, India

    Suraiya Saleem & Rajaretinam Rajesh Kannan

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  1. Suraiya Saleem
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  2. Rajaretinam Rajesh Kannan
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Correspondence to Rajaretinam Rajesh Kannan .

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  1. Department of Pharmacology, Symbiosis Medical College for Women, Pune, Maharashtra, India

    Prasan R. Bhandari

  2. Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), P. V. Narsimha Rao Telangana Veterinary University (PVNRTVU), Warangal, Telangana, India

    Kala Kumar Bharani

  3. Centre for Biomedical Engineering (CBME), Indian Institute of Technology (IIT) Delhi, New Delhi, Delhi, India

    Amit Khurana

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Saleem, S., Kannan, R.R. (2022). Zebrafish: A Potential Preclinical Model for Neurological Research in Modern Biology. In: Bhandari, P.R., Bharani, K.K., Khurana, A. (eds) Zebrafish Model for Biomedical Research . Springer, Singapore. https://doi.org/10.1007/978-981-16-5217-2_14

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