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Future Therapies for Diabetes

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Stroke Revisited: Diabetes in Stroke

Part of the book series: Stroke Revisited ((STROREV))

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Abstract

Diabetes is one of the most prevalent diseases and the most prevalent metabolic disorder. Pancreatic islet transplantation is a promising treatment for diabetes that aims to replace lost pancreatic beta cells. However, donor shortage is a problem. As an alternative to pancreatic islets derived from human donors, one option would be artificial functional pancreatic islet cells (bioartificial pancreatic islets). One such system, created using human pluripotent stem cells (hPSCs), would confer pancreatic beta cells with the ability to secrete insulin according to blood glucose level. However, the most suitable method for creating this system has not yet been established. The effect of the current transplant protocol is insufficient, and a greater functional improvement is required from pancreatic beta cells derived from hPSCs. On the other hand, pancreatic progenitor cells derived from hPSCs can mature into glucose-responsive beta cells after the transplant in vivo and transplantation methods are available. In addition, gene therapy studies are also being conducted. Other promising therapies include xenotransplantation of porcine pancreatic islets. In this review, I describe their advantages and problems.

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Authors and Affiliations

  1. Department of Pancreatic Islet Cell Transplantation, National Center for Global Health and Medicine, Tokyo, Japan

    Masayuki Shimoda

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  1. Masayuki Shimoda
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Correspondence to Masayuki Shimoda .

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Editors and Affiliations

  1. Department of Neurology, Seoul National University Hospital, Seoul, Korea (Republic of)

    Seung-Hoon Lee

  2. Korean Cerebrovascular Research Institute, Seoul, Korea (Republic of)

    Dong-Wan Kang

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Shimoda, M. (2021). Future Therapies for Diabetes. In: Lee, SH., Kang, DW. (eds) Stroke Revisited: Diabetes in Stroke. Stroke Revisited. Springer, Singapore. https://doi.org/10.1007/978-981-16-5123-6_16

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  • DOI: https://doi.org/10.1007/978-981-16-5123-6_16

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