Abstract
Graphene family nanomaterials (GFNs) are well-known carbonaceous materials, which find application in several fields like optoelectronics, photocatalysis, nanomedicine, and tissue regeneration. Despite possessing many advantages in biomedical applications, GFNs exhibited toxicity depending on various parameters including dosage, size, exposure time, and kinds of administration. GFNS are majorly classified into nanosheets, quantum dots, nanoplatelets, and nanoribbons based on morphology. Understanding the toxic effects of GFNs would provide new suggestions as to how the materials can be utilized effectively. Hence, we are summarizing here some of the recent findings in cellular and animal level toxicity studies of GFNs on the perspective of their different morphologies. Notwithstanding, we highlight progress, challenges, and new toxicological approaches to ensure biosafety of GFNs for future directions.
Iruthayapandi Selestin Raja and Anara Molkenova equally contributed to this work.
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Acknowledgments
This research was supported by National Research Foundation of Korea (NRF) funded by the Ministry of Science (NRF-2021R1A2C2006013) and by Korea Evaluation Institute of Industrial Technology (KEIT) grant funded by the Ministry of Trade, Industry and Energy (MOTIE, Korea) (No. 20014399).
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Raja, I.S. et al. (2022). Differential Toxicity of Graphene Family Nanomaterials Concerning Morphology. In: Han, DW., Hong, S.W. (eds) Multifaceted Biomedical Applications of Graphene. Advances in Experimental Medicine and Biology, vol 1351. Springer, Singapore. https://doi.org/10.1007/978-981-16-4923-3_2
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