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Indication of Pancreas Transplantation (Donor and Recipient)

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Pancreas Transplantation – the Asian Experience

Abstract

The vast majority of pancreas grafts are obtained from cadaver, heart-beating donors, and small portion from living donor. Although pancreas grafts from non-heart-beating donors have been successfully transplanted, this practice has been extremely limited [1, 2]. The suitability of a cadaver pancreas donor is based on general criteria common to all organ procurements as well as on specific pancreas-related factors.

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References

  1. Gruessner RW, Sutherland DER. Transplantation of pancreas. Chap 8.1.1. New York: Springer; 2004.

    Book  Google Scholar 

  2. Tojimbara T, Teraoka S, Babazono T, et al. Long-term outcome after combined pancreas and kidney transplantation from nonheart-beating cadaver donors. Transplant Proc. 1998;30:3793–4.

    Article  CAS  PubMed  Google Scholar 

  3. Kapur S, Bonharn CA, Dodson SF, Dvorchik I, et al. Strategies to expand the donor pool for pancreas transplantation. Transplantation. 1999;67:284–90.

    Article  CAS  PubMed  Google Scholar 

  4. Sutherland DE, Goetz C, Najarian JS. Pancreas transplantation at the University of Minnesota: donor and recipient selection, operative and postoperative management, and outcome. Transplant Proc. 1987;19(Supp1 4):63–74.

    CAS  PubMed  Google Scholar 

  5. Penn I. Malignancies associated with immunosuppressive or cytotoxic therapy. Surgery. 1978;83:492–502.

    CAS  PubMed  Google Scholar 

  6. Gottesdiener KM. Transplanted infections: donor-to-host transmission with the allograft. Ann Intern Med. 1989;110:1001–16.

    Article  CAS  PubMed  Google Scholar 

  7. Nelson PW, Delmonieo FL, Tolkoff-Rubin NE, et al. Unsuspected donor Pseudomonas infection causing arterial disruption after renal transplantation. Transplantation. 1984;37:313–4.

    Article  CAS  PubMed  Google Scholar 

  8. O’Connor KJ, DelMonico FL. Donor selection and management. In: Ginns LC, Cosimi AB, Morris PJ, editors. Transplantation. Oxford, UK: Blackwell Science; 1999. p. 239–69.

    Google Scholar 

  9. Benedetti E, Gruessner AC, Troppmann C, Papalois BE, Sutherland DE, Dunn DL, Gruessner RW. Intra-abdominal fungal infections after pancreatic transplantation: incidence, treatment, and outcome. J Am Coll Surg. 1996;183:307–16.

    CAS  PubMed  Google Scholar 

  10. Gibe LJ, Sterling W, Hoy W, Harford A. Is serological evidence of infection with syphilis a contraindication to kidney donation? Case report and review of the literature. J Urol. 1987;138:1226–7.

    Article  Google Scholar 

  11. Lutwick LI, Sywassink JM, Corry RJ, Shorey JW. The transmission of hepatitis B by renal transplantation. Clin Nephrol. 1983;19:317–9.

    CAS  PubMed  Google Scholar 

  12. Gonzalez-Peralta RP, Andres JM, Tung FY, et al. Transplantation of a hepatitis B surface antigen-positive donor liver into a hepatitis B virus-negative recipient. Transplantation. 1994;58:114–6.

    Article  CAS  PubMed  Google Scholar 

  13. Wachs ME, Amend WJ, Ascher NL, et al. The risk of transmission of hepatitis B from HBsAg(-), HBcAb(+), HBIgM(-)organ donors. Transplantation. 1995;59:230–4.

    Article  CAS  PubMed  Google Scholar 

  14. Dodson SF, Issa S, Araya V, et al. Infectivity of hepatic allografts with antibodies to hepatitis B virus. Transplantation. 1997;64:1582–4.

    Article  CAS  PubMed  Google Scholar 

  15. Sutherland DE, Gruessner R, Gillingham K, et al. A single institution’s experience with solitary pancreas transplantation: a multivariate analysis of factors leading to improved outcome. Clin Transplant. 1991:141–52.

    Google Scholar 

  16. Gruessner AC, Barrou B, Jones J, et al. Donor impact on outcome of bladder-drained pancreas transplants. Transplant Proc. 1993;25:3114–5.

    CAS  PubMed  Google Scholar 

  17. Bonham CA, Kapur S, Dodson SF, et al. Potential use of marginal donors for pancreas transplantation. Transplant Proc. 1999;31:612–3.

    Article  CAS  PubMed  Google Scholar 

  18. Gruessner RW, Sutherland DE, Troppmann C, et al. The surgical risk of pancreas transplantation in the cyclosporine era: an overview. J Am Coll Surg. 1997;185:128–44.

    Article  CAS  PubMed  Google Scholar 

  19. Hantson P, Mahieu P, Hassoun A, Otte JB. Outcome following organ removal from poisoned donors in brain death status: a report of 12 cases and review of the literature. J Toxicol Clin Toxicol. 1995;33:709–12.

    Article  CAS  PubMed  Google Scholar 

  20. Barkoukis TJ, Sarbak CA, Lewis D, Whittier FC. Multiorgan procurement from a victim of cyanide poisoning. A case report and review of the literature. Transplantation. 1993;55:1434–6.

    Article  CAS  PubMed  Google Scholar 

  21. Friedlaender MM, Rosenmann E, Rubinger D, et al. Successful renal transplantation from two donors with methanol intoxication. Transplantation. 1996;61:1549–52.

    Article  CAS  PubMed  Google Scholar 

  22. Hantson P, Vekemans MC, Squifflet JP, Mahieu P. Outcome following organ removal from poisoned donors: experience with 12 cases and a review of the literature. Transplant Int. 1995;8:185–9.

    Article  CAS  Google Scholar 

  23. Gores PF, Gillingham KJ, Dunn DL, et al. Donor hyperglycemia as a minor risk factor and immunologic variables as major risk factors for pancreas allograft loss in a multivariate analysis of a single institution’s experience. Ann Surg. 1992;215:217–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Sutherland DER, Gruessner RWG. Current status of pancreas transplantation for the treatment of type I diabetes mellitus. Acta Gastroenterol Belg. 1997;60:294–7.

    CAS  PubMed  Google Scholar 

  25. Shaffer D, Madras PN, Sahyoun AI, et al. Cadaver donor hyperglycemia does not impair long-term pancreas allograft survival or function. Transplant Proc. 1994;26:439–40.

    CAS  PubMed  Google Scholar 

  26. Hesse VJ, Sutherland DE. Influence of serum amylase and plasma glucose levels in pancreas cadaver donors on graft function in recipients. Diabetes. 1989;38:1–3.

    Article  PubMed  Google Scholar 

  27. Troppmann C, Gruessner AC, Benedetti E, et al. Vascular graft thrombosis after pancreatic transplantation: univariate and multivariate operative and nonoperative risk factor analysis. J Am Coll Surg. 1996;182:285–316.

    CAS  PubMed  Google Scholar 

  28. Ciealese L, Giacomoni A, Rastellini C, Benedetti E. Pancreatic transplantation: a review. Int Surg. 1999;84:305–12.

    Google Scholar 

  29. Criteria of the donor for pancreas transplantation. Website of Central committee for pancreas transplantation in Japan. http://www.ptccc.jp/.

  30. Health Bureau, Ministry of Health, Labor and Welfare, Health, Issue No. 798, July 30, 2001).

    Google Scholar 

  31. Health Bureau, Ministry of Health, Labor and Welfare, Health, Issue 0114 No. 3, January 14, 2010).

    Google Scholar 

  32. Sasaki TM, Gray RS, Ratner RE, et al. Successful long-term kidney-pancreas transplants in diabetic patients with high C-peptide levels. Transplantation. 1998;65:1510–2.

    Article  CAS  PubMed  Google Scholar 

  33. Gruessner AC, Laftavi MR, Pankewycz O, Gruessner RWG. Simultaneous pancreas and kidney transplantation-is it a treatment option for patients with type 2 diabetes mellitus? An analysis of the International Pancreas Transplant Registry. Curr Diab Rep. 2017;17(6):44.

    Article  PubMed  Google Scholar 

  34. Margreiter C, Resch T, Oberhuber R, Aigner F, Maier H, Sucher R, Schneeberger S, Ulmer H, Bösmüller C, Margreiter R, Pratschke J, Öllinger R. Combined pancreas-kidney transplantation for patients with end-stage nephropathy caused by type-2 diabetes mellitus. Transplantation. 2013;95(8):1030–6.

    Article  CAS  PubMed  Google Scholar 

  35. Sampaio MS, Kuo H-T, Bunnapradist S. Outcomes of simultaneous pancreas-kidney transplantation in type 2 diabetic recipients. Clin J Am Soc Nephrol. 2011;6(5):1198–206.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Shin S, Jung CH, Choi JY, Kwon HW, Jung JH, Kim YH, Han DJ. Long-term metabolic outcomes of functioning pancreas transplants in type 2 diabetic recipients. Transplantation. 2017;101(6):1254–60.

    Article  CAS  PubMed  Google Scholar 

  37. Sutherland DE. Is immunosuppression justified for nonuremic diabetic patients to keep them insulin independent? (The argument for). Transplant Proc. 2002;34:1927–8.

    Article  CAS  PubMed  Google Scholar 

  38. Cryer PE. Hypoglycemia-associated autonomic failure in diabetes. Am J Physiol Endocrinol Metab. 2001;281:E1115–21.

    Article  CAS  PubMed  Google Scholar 

  39. Gruessner RW, Sutherland DE, Drangstveit MB, Bland BJ, Gruessner AC. Pancreas transplants from living donors: short- and long-term outcome. Transplant Proc. 2001;33:819–20.

    Article  CAS  PubMed  Google Scholar 

  40. Sutherland DER, Gruessner RGW, Humar A, Kandaswamy R, Najarian JS, Dunn DL, Gruessner A. Pretransplant immunosuppression for pancreas transplants alone in nonuremic diabetic recipients. Transplant Proc. 2001;33:1656–8.

    Article  CAS  PubMed  Google Scholar 

  41. Quinibi WY, Al-Sibai MB, Taher S, et al. Mycobacterial infection after renal transplantation-report of 14 cases and review of the literature. Q J Med. 1990;77:1039–60.

    Article  Google Scholar 

  42. Weir MR, Irwin BC, Maters AW, et al. Incidence of cytomegalovirus disease in cyclosporine-treated renal transplant recipients based on donor-recipient pre-transplant immunity. Transplantation. 1987;43:187–91.

    Article  CAS  PubMed  Google Scholar 

  43. Green M. Management of Epstein-Barr virus induced post-transplant lymphoproliferative disease in recipients of solid organ transplantation. Am J Transplant. 2001;1:103–8.

    CAS  PubMed  Google Scholar 

  44. Hiesse C, Buffet C, Neyrat N, et al. Impact of hepatitis B antigenemia on long-term patient survival and causes of death after renal transplantation. Clin Transplant. 1992;46:461–7.

    Google Scholar 

  45. Popkin MK, Callies AL, Colon EA. Psychiatric diagnosis and the surgical outcome of pancreas transplantation in patients with type I diabetes mellitus. Psychosomatics. 1993;34:251–8.

    Article  CAS  PubMed  Google Scholar 

  46. Kim SH, Ha YE, Youn JC, et al. Fatal scedosporiosis in multiple solid organ allografts transmitted from a nearly drowned donor. Am J Transplant. 2015;15:833–40.

    Article  CAS  PubMed  Google Scholar 

  47. Lackner M, de Hoog GS, Verweij PE, et al. Species specific antifungal susceptibility patterns of scedosporium and pseudallescheria species. Antimicrob Agents Chemother. 2012;56:2635–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Criteria of the recipient for pancreas transplantation. Website of Central committee for pancreas transplantation in Japan. http://www.ptccc.jp/.

  49. Recipient selection criteria for deceased donor pancreas transplantation. Website of JOT, https://www.jotnw.or.jp/files/news1/2020/rec-pancreas.pdf.

  50. Taiwan Organ Registry and Sharing Center. (http://www.torsc.org.tw/about/about_08.jsp.

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Author information

Authors and Affiliations

  1. Saitama Prefectural University, Koshigaya, Japan

    Takuya Awata

  2. Fujita Health University, Toyoake, Japan

    Takashi Kenmochi

  3. Department of Surgery, General surgery, Taipei Veterans General Hospital, Taipei, Taiwan

    Yi-Ming Shyr

  4. Asan Medical Center, Seoul, Korea

    Duck-Jong Han

Authors
  1. Takuya Awata
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  2. Takashi Kenmochi
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  3. Yi-Ming Shyr
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  4. Duck-Jong Han
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Editor information

Editors and Affiliations

  1. Department of Surgery, Asan Medical Center, Seoul, Korea (Republic of)

    Duck-Jong Han

  2. Department of Organ Transplant Surg, Fujita Health University, Toyoake, Aichi, Japan

    Takashi Kenmochi

  3. Department of Surgery, General surgery, Taipei Veterans General Hospital, Taipei, Taiwan

    Yi-Ming Shyr

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Awata, T., Kenmochi, T., Shyr, YM., Han, DJ. (2022). Indication of Pancreas Transplantation (Donor and Recipient). In: Han, DJ., Kenmochi, T., Shyr, YM. (eds) Pancreas Transplantation – the Asian Experience. Springer, Singapore. https://doi.org/10.1007/978-981-16-4597-6_2

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  • DOI: https://doi.org/10.1007/978-981-16-4597-6_2

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-4596-9

  • Online ISBN: 978-981-16-4597-6

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