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Biomimetic Nanosystems in Targeted Drug Delivery

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Biomimetic Biomaterials for Tissue Regeneration and Drug Delivery

Abstract

Nanotechnology in cancer has been a boon to the translational science bringing advantages to the conventional drug delivery approaches. There are different types of nanoparticles such as liposomes, dendrimers, and mesoporous silica nanoparticles that are being employed to improve the overall biodistribution of the drug; however, this often fails in in vivo model due to the lack of stealth property, ultimately leading to immune rejection. PEG, chitosan, etc. are polymeric coatings that have been used as stealth covering around nanoparticles that prevent the nanoparticles from aggregation of proteins and opsonization. However, synthesis of polymeric coatings requires chemistries for conjugation that are often tedious and labor intensive. In this scenario, biomimetic nanoparticles have become convenient as they can be produced without much use of organic solvents. In addition, they can mediate natural targeting due to the virtue of homotypic interaction with membrane proteins present on the host cell. In addition, they can also prevent immune recognition due to the presence of marker proteins that are often recognized as “self” by the body. There have been several achievements in this field; still there are certain limitations that need to be dealt with. Techniques to produce biomimetic nanoparticles in a cost-effective manner in larger batches can lessen the burden in manufacturing process. Biomimetic nanoparticles possess immense benefits with better targeting and stealth property that can reduce the shortcomings of the traditional nanoparticles employed.

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Authors and Affiliations

  1. Institute of Life Sciences, Bhubaneswar, Odisha, India

    Pratigyan Dash & Mamoni Dash

  2. School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) University, Bhubaneswar, Odisha, India

    Pratigyan Dash

Authors
  1. Pratigyan Dash
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  2. Mamoni Dash
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Correspondence to Mamoni Dash .

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Editors and Affiliations

  1. Institute of Life Sciences, Bhubaneswar, Odisha, India

    Mamoni Dash

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Dash, P., Dash, M. (2022). Biomimetic Nanosystems in Targeted Drug Delivery. In: Dash, M. (eds) Biomimetic Biomaterials for Tissue Regeneration and Drug Delivery. Springer, Singapore. https://doi.org/10.1007/978-981-16-4566-2_3

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