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Impact of Common Natural Compound in the Treatment of Alzheimer’s Disease

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Autism Spectrum Disorder and Alzheimer's Disease

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Abstract

Alzheimer’s disease (AD) is considered one of the most complex neurodegenerative disorders. Amyloid and tau pathology, along with neurofibrillary tangles, are most commonly seen in this disease. Various compounds show promising responses in treating this disease, but they also cause severe side effects. To minimize these side effects, researchers explored several natural products for the treatment of this disease. Natural products cause very minimal side effects as compared to isolated chemical compounds. The minimal side effect might be due to the complex synergistic effects of various bioactive components present in these natural products. Several natural products like green tea, epigallocatechin gallate, baicalein, berberine, and quercetin show a robust response in the treatment of AD. Some natural compounds like Ginkgo biloba extract and Huperzine A passed the clinical trial on PD. This chapter has explored the potential of some of the most common natural products to treat AD in a sequence-wide manner.

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Acknowledgments

Authors would like to acknowledge UGC Dr. D.S. Kothari Postdoctoral scheme for awarding the fellowship to Dr. Sachchida Nand Rai (Ref. No-F.4-2/2006 (BSR)/BL/19-20/0032). CS, VK, HH, TB, VP, and AS wish to thank Director, ISF College of Pharmacy, Moga, for motivation to write this manuscript.

Conflict of Interest

All authors declared that there is no conflict of interest.

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Author notes

  1. Vishav Prabhjot Kaur and Sachchida Nand Rai contributed equally to this work.

Authors and Affiliations

  1. Department of Pharmaceutics, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, India

    Vishav Prabhjot Kaur, Tania Bajaj, Hemraj Heer, Vishal Puri, Arti Singh & Charan Singh

  2. Centre of Biotechnology, University of Allahabad, Prayagraj, Uttar Pardesh, India

    Sachchida Nand Rai, Vivek K. Chaturvedi & M. P. Singh

  3. Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

    Ghulam Md Ashraf

  4. King Fahd Medical Research Center, Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia

    Ghulam Md Ashraf

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  1. Vishav Prabhjot Kaur
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  1. King Fahd Medical Research Center Department of Medical Laboratory Sciences Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia

    Ghulam Md Ashraf

  2. Department of Science and Engineering, Novel Global Community Educational Foundation, Sydney, Australia

    Athanasios Alexiou

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Kaur, V.P. et al. (2021). Impact of Common Natural Compound in the Treatment of Alzheimer’s Disease. In: Md Ashraf, G., Alexiou, A. (eds) Autism Spectrum Disorder and Alzheimer's Disease . Springer, Singapore. https://doi.org/10.1007/978-981-16-4558-7_4

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