Abstract
In recent times, microchannel and its fabrication have found immense recognition in biomedical applications. It is because, the microchannels provide devices that are economical and portable. They can be widely used in miniaturized biomedical devices with lab-on-a-chip concept such as electrochemical sensors, microfluidic devices, circuit patterning and microreactors. Thus, keeping in view the importance of the microchannels, this chapter reviews several advanced fabrication technologies of microchannels such as lithography, microwire moulding, imprinting, direct laser micromachining and laser-induced plasma-assisted ablation, each with many advantages and disadvantages. A brief study on the operation principle of each of these fabrication processes, its process parameters, process capabilities and its recent advancements is conveyed. It has been found that laser has certain advantages over the other fabrication technologies. It has proved to be most time saving and precise. As such, discussion on the laser fabrication technology of microchannel is presented with more emphasis on it. Additionally, some of the experimental results of microchannel formation and its thermal bonding to get a closed microchannel have also been presented. This chapter signifies the diverse applications of the microchannels as well.
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References
Daghighi, Y.: Microfluidic technology and its biomedical applications. J. Ther. Eng. 1(7), 621–626 (2015)
Pan, C., Chen, K., Liu, B., Ren, L., Wang, J., Hu, Q., Liang, L., Zhou, J., Jiang, L.: Fabrication of micro-texture channel on glass by laser-induced plasma-assisted ablation and chemical corrosion for microfluidic devices. J. Mater. Process. Technol. 240, 314–323 (2017)
Xu, S., Liu, B., Pan, C., Ren, L., Tang, B., Hu, Q., Jiang, L.: Ultrafast fabrication of micro-channels and graphite patterns on glass by nanosecond laser-induced plasma-assisted ablation (LIPAA) for electrofluidic devices. J. Mater. Process. Technol. 247, 204–213 (2017)
Kim, H.G., Park, M.S.: Circuit patterning using laser on transparent material. Surf. Coat. Technol. 315, 377–384 (2017)
Suryawanshi, P.L., Gumfekar, S.P., Bhanvase, B.A., Sonawane, S.H., Pimplapure, M.S.: A review on microreactors: reactor fabrication, design, and cutting-edge applications. Chem. Eng. Sci. 189, 431–448 (2018)
Chandra, P., Segal, E.: Nanobiosensors for Personalized and Onsite Biomedical Diagnosis. The Institution of Engineering and Technology (2016)
Shirzadfar, H., Khanahmadi, M.: Review on structure, function and applications of microfluidic systems. Int. J. Biosens. Bioelectron. 4(6), 263–265 (2018)
Nieto, D., Delgado, T., Flores-Arias, M.T.: Fabrication of microchannels on soda-lime glass substrates with a Nd: YVO4 laser. Opt. Lasers Eng. 63, 11–18 (2014)
Singh, S.S., Baruah, P.K., Khare, A., Joshi, S.N.: Effect of laser beam conditioning on fabrication of clean micro-channel on stainless steel 316L using second harmonic of Q-switched Nd: YAG laser. Opt. Laser Technol. 99, 107–117 (2018)
Kim, K.R., Kim, H.J., Choi, H.I., Shin, K.S., Cho, S.H., Choi, B.D.: Ultrafast laser microfabrication of a trapping device for colorectal cancer cells. Microelectron. Eng. 140, 1–5 (2015)
Li, G., Xu, S.: Small diameter microchannel of PDMS and complex three-dimensional microchannel network. Mater. Des. 81, 82–86 (2015)
Prakash, S., Kumar, S.: Fabrication of rectangular cross-sectional microchannels on PMMA with a CO2 laser and underwater fabricated copper mask. Opt. Laser Technol. 94, 180–192 (2017)
Kanca, Y., Milner, P., Dini, D., Amis, A.A.: Tribological evaluation of biomedical polycarbonate urethanes against articular cartilage. J. Mech. Behav. Biomed. Mater. 82, 394–402 (2018)
Mehendale, S.S., Jacobi, A.M., Shah, R.K.: Fluid flow and heat transfer at micro- and meso-scales with application to heat exchanger design. ASME. Appl. Mech. Rev. 53(7), 175–193 (2000)
Kandlikar, S.G., Grande, W.J.: Evolution of microchannel flow passages–thermohydraulic performance and fabrication technology. Heat Transf. Eng. 24(1), 3–17 (2003)
Effati, E., Pourabbas, B.: New portable microchannel molding system based on micro-wire molding, droplet formation studies in circular cross-section microchannel. Mater. Today Commun. 16, 119–123 (2018)
Kumar, U., Panda, D., Biswas, K.G.: Non-lithographic copper-wire based fabrication of micro-fluidic reactors for biphasic flow applications. Chem. Eng. J. 344, 221–227 (2018)
Su, S., Jing, G., Zhang, M., Liu, B., Zhu, X., Wang, B., Fu, M., Zhu, L., Cheng, J., Guo, Y.: One-step bonding and hydrophobic surface modification method for rapid fabrication of polycarbonate-based droplet microfluidic chips. Sens. Actuators, B Chem. 282, 60–68 (2019)
Liu, Y., Ganser, D., Schneider, A., Liu, R., Grodzinski, P., Kroutchinina, N.: Microfabricated polycarbonate CE devices for DNA analysis. Anal. Chem. 73(17), 4196–4201 (2001)
Xu, J., Locascio, L., Gaitan, M., Lee, C.S.: Room-temperature imprinting method for plastic microchannel fabrication. Anal. Chem. 72(8), 1930–1933 (2000)
Yao, P., Schneider, G.J., Prather, D.W.: Three-dimensional lithographical fabrication of microchannels. J. Microelectromech. Syst. 14(4), 799–805 (2005)
Hirschbiel, A.F., Geyer, S., Yameen, B., Welle, A., Nikolov, P., Giselbrecht, S., Scholpp, S., Delaittre, G., Barner-Kowollik, C.: Photolithographic patterning of 3D-formed polycarbonate films for targeted cell guiding. Adv. Mater. 27(16), 2621–2626 (2015)
Retolaza, A., Juarros, A., Ramiro, J., Merino, S.: Thermal roll to roll nanoimprint lithography for micropillars fabrication on thermoplastics. Microelectron. Eng. 193, 54–61 (2018)
Wu, H.C., Xu, X., He, M., Zhang, M., Ma, K.J., Bao, M.: Fabrication of size-tunable antireflective nanopillar array using hybrid nano-patterning lithography. Surf. Coat. Technol. 240, 413–418 (2014)
Chen, P.C., Pan, C.W., Lee, W.C., Li, K.M.: Optimization of micromilling microchannels on a polycarbonate substrate. Int. J. Precis. Eng. Manuf. 15(1), 149–154 (2014)
Getu, H., Ghobeity, A., Spelt, J.K., Papini, M.: Abrasive jet micromachining of acrylic and polycarbonate polymers at oblique angles of attack. Wear 265(5–6), 888–901 (2008)
Zhang, L., Wang, W., Ju, X.J., Xie, R., Liu, Z., Chu, L.Y.: Fabrication of glass-based microfluidic devices with dry film photoresists as pattern transfer masks for wet etching. RSC Adv. 5(8), 5638–5646 (2015)
Kang, J.W., Kim, J.S., Kim, J.J.: Optimized oxygen plasma etching of polycarbonate for low-loss optical waveguide fabrication. Jpn. J. Appl. Phys. 40(5R), 3215 (2001)
Jia, Y., Jiang, J., Ma, X., Li, Y., Huang, H., Cai, K., Cai, S., Wu, Y.: PDMS microchannel fabrication technique based on microwire-molding. Chin. Sci. Bull. 53(24), 3928–3936 (2008)
McUsic, A.C., Lamba, D.A., Reh, T.A.: Guiding the morphogenesis of dissociated newborn mouse retinal cells and hES cell-derived retinal cells by soft lithography-patterned microchannel PLGA scaffolds. Biomaterials 33(5), 1396–1405 (2012)
Laviano, F., Ghigo, G., Mezzetti, E., Hollmann, E., Wördenweber, R.: Control of the vortex flow in microchannel arrays produced in YBCO films by heavy-ion lithography. Phys. C 470(19), 844–847 (2010)
Wang, S., Wang, X., Wang, L., Pu, Q., Du, W., Guo, G.: Plasma-assisted alignment in the fabrication of microchannel-array-based in-tube solid-phase microextraction microchips packed with TiO2 nanoparticles for phosphopeptide analysis. Anal. Chim. Acta 1018, 70–77 (2018)
Zhai, H., Li, J., Chen, Z., Su, Z., Liu, Z., Yu, X.: A glass/PDMS electrophoresis microchip embedded with molecular imprinting SPE monolith for contactless conductivity detection. Microchem. J. 114, 223–228 (2014)
Lei, J.D., Tong, A.J.: Preparation of Zl-Phe-OH-NBD imprinted microchannel and its molecular recognition study. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 61(6), 1029–1033 (2005)
McCann, R., Bagga, K., Groarke, R., Stalcup, A., Vázquez, M., Brabazon, D.: Microchannel fabrication on cyclic olefin polymer substrates via 1064 nm Nd: YAG laser ablation. Appl. Surf. Sci. 387, 603–608 (2016)
Wu, T., Ke, C., Wang, Y.: Fabrication of trapezoidal cross-sectional microchannels on PMMA with a multi-pass translational method by CO2 laser. Optik 183, 953–961 (2019)
Mohammed, M.K., Umer, U., Al-Ahmari, A.: Optimization of Nd: YAG laser for microchannels fabrication in alumina ceramic. J. Manuf. Process. 41, 148–158 (2019)
Singh, S.S., Khare, A., Joshi, S.N.: Fabrication of microchannel on polycarbonate below the laser ablation threshold by repeated scan via the second harmonic of Q-switched Nd: YAG laser. J. Manuf. Process. 55, 359–372 (2020)
Sugioka, K., Midorikawa, K., Yamaoka, H., Gomi, Y., Otsuki, M., Hong, M.H., Wu, D.J., Wong, L.L., Chong, T.C.: Glass microprocessing by laser-induced plasma-assisted ablation: fundamental to industrial applications. In: Nonresonant Laser-Matter Interaction (NLMI-11), pp. 1–10. St. Petersburg (2003)
Sarma, U., Joshi, S.N.: Machining of micro-channels on polycarbonate by using Laser-Induced Plasma Assisted Ablation (LIPAA). Opt. Laser Technol. 128, 106257 (2020)
Pallav, K., Saxena, I., Ehmann, K.F.: Comparative assessment of the laser-induced plasma micromachining and the ultrashort pulsed laser ablation processes. J. Micro Nano-Manuf. 2(3), 031001 (2014)
Bhandari, S., Murnal, M., Cao, J., Ehmann, K.: Comparative experimental investigation of micro-channel fabrication in Ti alloys by laser ablation and laser-induced plasma micro-machining. Proc. Manuf. 34, 418–423 (2019)
Malhotra, R., Saxena, I., Ehmann, K., Cao, J.: Laser-induced plasma micro-machining (LIPMM) for enhanced productivity and flexibility in laser-based micro-machining processes. CIRP Ann. 62(1), 211–214 (2013)
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Sarma, U., Chandra, P., Joshi, S.N. (2022). Advanced Microchannel Fabrication Technologies for Biomedical Devices. In: Joshi, S.N., Chandra, P. (eds) Advanced Micro- and Nano-manufacturing Technologies. Materials Horizons: From Nature to Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-16-3645-5_6
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DOI: https://doi.org/10.1007/978-981-16-3645-5_6
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