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Developing Brain and Anesthetic Neurotoxicity

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Fundamentals of Pediatric Neuroanesthesia

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Abstract

Within the last decade, animal models of anesthetic neurotoxicity and related developmental disorders have raised concerns for comparable effects in children after exposure to general anesthesia in early infancy. Millions of children undergo surgery during their first 4 years of life worldwide. Delaying non-elective surgical procedures might put children at risk of disease progression including neurodevelopmental impairment. Moreover, controlled anesthetic exposure is difficult to accomplish. This chapter describes the developing brain and different aspects of anesthesia-induced neurotoxicity.

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Authors and Affiliations

  1. Department of Anesthesiology and Neurological Surgery, Stony Brook University, Stony Brook, NY, USA

    Sergio D. Bergese

  2. Department of Anesthesiology, Women’s Hospital, Pereira Rossell Medical Center, Montevideo, Uruguay

    Fabrizzio Sacchet-Cardozo

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  1. Sergio D. Bergese
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  2. Fabrizzio Sacchet-Cardozo
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Correspondence to Sergio D. Bergese .

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  1. Department of Neuroanesthesiology & Critical Care, All India Institute of Medical Sciences, New Delhi, Delhi, India

    Girija Prasad Rath

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Bergese, S.D., Sacchet-Cardozo, F. (2021). Developing Brain and Anesthetic Neurotoxicity. In: Rath, G.P. (eds) Fundamentals of Pediatric Neuroanesthesia. Springer, Singapore. https://doi.org/10.1007/978-981-16-3376-8_41

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  • DOI: https://doi.org/10.1007/978-981-16-3376-8_41

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