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Implications of Synthesis Methodology on Physicochemical and Biological Properties of Hydroxyapatite

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Handbook on Synthesis Strategies for Advanced Materials

Part of the book series: Indian Institute of Metals Series ((IIMS))

Abstract

Hydroxyapatite (HAp) is a well-known ceramic biomaterial, which has widely been used in various biomedical applications. It has garnered the attention of researchers mainly due to its chemical and mechanical similarities with the apatite phase present in the bones and teeth of humans. Owing to its biological similarity, HAp has excellent biocompatibility and can trigger both osteoconduction and osteoinduction activities. Therefore, HAp has been employed in a wide range of therapeutic applications ranging from simple dental fillings, bioactive coatings on implants to strategically designed drug delivery systems, and even for tissue engineering applications. Synthesis methodology plays an important role in determining the physicochemical properties of HAp, which in turn affects its mechanical and biological performance. The desired characteristics of HAp can be achieved by choosing an appropriate method of synthesis with optimized reaction conditions. This chapter, in depth, will discuss the various methods of synthesizing HAp, along with their advantages and disadvantages and implications on physicochemical characteristics and biological performance.

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Acknowledgements

Dr. Gunjan Verma thanks Dr. A. K. Tyagi, Associate Director, Chemistry Group, BARC, and Dr. P. A. Hassan, Head, Nanotherapeutics and Biosensor Section, BARC, for their constant support and encouragement. Ms. Mural Quadros thanks Mrs. Ozilia Quadros for being a pillar of unwavering support, guidance, and motivation.

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Authors and Affiliations

  1. Chemistry Division, Bhabha Atomic Research Centre, Mumbai 400 085, India

    Mural Quadros & Gunjan Verma

  2. Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle, Mumbai 400 056, India

    Mural Quadros & Munira Momin

  3. Homi Bhabha National Institute, Mumbai 400 094, India

    Gunjan Verma

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  1. Mural Quadros
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  2. Munira Momin
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Correspondence to Gunjan Verma .

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  1. Chemistry Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India

    A. K. Tyagi

  2. Chemistry Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India

    Raghumani S. Ningthoujam

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Quadros, M., Momin, M., Verma, G. (2022). Implications of Synthesis Methodology on Physicochemical and Biological Properties of Hydroxyapatite. In: Tyagi, A.K., Ningthoujam, R.S. (eds) Handbook on Synthesis Strategies for Advanced Materials. Indian Institute of Metals Series. Springer, Singapore. https://doi.org/10.1007/978-981-16-1803-1_15

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