Abstract
The model that G-quadruplexes (G4) form in living cells has long been accepted due to their specific location and their evolutionary conservation. G4s are discussed to affect cellular functions. In the past, mainly negative impacts of G4s on cell function and genome stability were observed. However, in recent years, it became evident that G4s fulfill a purpose in living cells, to support and fine tune cellular pathways and functions. If stable G4s are a molecular tool in living cells, two classes of proteins are required, one type of protein to support the formation of G4s and a second type which recognizes the folded nucleic acid structure. In this chapter, we summarized the G4 interacting proteins that were identified either in global assays or by specific biochemical methods. In particular, we summarized and discussed if protein-G4 interaction was experimentally determined in vitro and in vivo and how this impacts cellular functions.
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Acknowledgments
Due to citation limitations, we majorly cited review articles in the review. We apologize to all authors if their work was not directly cited. Research in the Paeschke laboratory is funded by an ERC Stg Grant (638988-G4DSB) and by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation): Project-ID 369799452 – TRR237” and under Germany’s Excellence Strategy – EXC2151 – 390873048.
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Simon, P., Schult, P., Paeschke, K. (2023). Binding and Modulation of G-quadruplex DNA and RNA Structures by Proteins. In: Sugimoto, N. (eds) Handbook of Chemical Biology of Nucleic Acids. Springer, Singapore. https://doi.org/10.1007/978-981-16-1313-5_102-1
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