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Mesenchymal Stem Cells

A Boon or Bane in Cancer Progression and Metastasis

  • Living reference work entry
  • First Online:
Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Tumor microenvironment (TME) is a complex network with a heterogeneous ensemble of cancer cells, mesenchymal stromal/stem cells (MSCs), inflammatory cells, immune cells, secreted factors, and extracellular matrix proteins. The interaction between cancer cells and its microenvironment decides the fate of tumors. This justifies the present impetus to target the components of the TME for better therapeutic responses. MSCs are integral components of the TME that play an active role in tumor initiation, progression, and metastasis. MSCs, owing to their antitumorigenic activity, ease of isolation, and inherent migratory capabilities, have emerged as effective anticancer therapeutics. In the present chapter, we discuss recent advances on the role of MSCs as potent antitumor agents. Additionally, we explore the therapeutic potential of MSCs and MSC-derived extracellular vesicles as carriers for anticancer agents at the preclinical and clinical levels. Therefore, it is anticipated that the new insights into the use of MSCs as anticancer agents will lead to the development of novel stem cell-based therapeutic strategies that enhance the safety and survivability of cancer patients.

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Acknowledgments

AD acknowledges institutional funding provided by the Council of Scientific and Industrial Research (CSIR), Ministry of Science and Technology, Government of India for Projects under Healthcare theme. The fellowship provided by CSIR-JRF/SRF to RY is gratefully acknowledged (Manuscript Communication number: IICT/Pubs./2021/130).

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Applied Biology, Council of Scientific & Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, TS, India

    Ragini Yeeravalli & Amitava Das

  2. Academy of Scientific and Innovative Research, Ghaziabad, UP, India

    Ragini Yeeravalli & Amitava Das

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  1. Ragini Yeeravalli
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  2. Amitava Das
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Correspondence to Amitava Das .

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Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Cellular Stress and Immune Response Laboratory, Centre for Cancer Biology, University of South Australia, Adelaide, South Australia, Australia

    Nirmal Robinson

  2. Department of Morphofunctional Sciences, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

    Cornelia Amalinei

  3. Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana State, India

    Amitava Das

  4. Biological Sciences, Academy of Scientific and Innovative Research, Ghaziabad,, UP, India

    Amitava Das

  5. Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Chennai, Tamil Nadu, India

    Surajit Pathak

  6. Stem Cell Facility, DBT-Centre of Excellence for Stem Cell Research, All India Institute of Medical Sciences, New Delhi, India

    Sujata Mohanty

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Yeeravalli, R., Das, A. (2022). Mesenchymal Stem Cells. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_228-1

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