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Protective Effect of Quercetin, Luteolin, and Fisetin via Stimulating the p53-Mediated Signaling in Cancer

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Cancer, a leading cause of global mortality, has been estimated to cause more deaths than all coronary heart disease or stroke. Mutation in the p53 gene is one of the major etiologies leading to carcinogenesis. p53 regarded as the “Guardian of the genome” regulates a large number of events including cell cycle arrest and apoptosis, among others. Treatment of cancer has mostly been confined to chemotherapy, radiotherapy, and surgery. However, these therapies can cause a severe threat to the life of the individual. Natural plant products have also been used due to their protective effect against various types of cancer. Quercetin, Luteolin, and Fisetin are polyphenolic compounds widely found in fruits and vegetables. They have been reported to possess antioxidant, anti-inflammatory, and antiproliferative properties among others. These properties make them a good candidate as an anticancer agent. Quercetin, Luteolin, and Fisetin have been shown to have a positive effect on the p53 expression. p53 shows potential in suppressing the expression of NF-κB, thereby repressing inflammation. Quercetin-, Luteolin-, and Fisetin-mediated stimulation of p53 causes arrest of cancerous cells at the various checkpoint of the cell cycle which further leads to apoptosis of cancerous cells. This section, therefore, discusses the anticancerous effect of quercetin, Luteolin, and Fisetin on the p53-mediated signaling in cancer.

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Authors and Affiliations

  1. Department of Toxicology, Jamia Hamdard, New Delhi, India

    Johirul Islam

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  1. Johirul Islam
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Editor information

Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Department of Internal Medicine, General Hospital Minamiseiko Hospital, Nagoya, Japan

    Takehiko Takayanagi

  2. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA

    Prakash Radhakrishnan

  3. Department of Nutrition and Dietetics, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey

    Ayse Günes-Bayir

  4. Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, Illinois, USA

    Gnanasekar Munirathinam

  5. Dean, Research, Central University of Punjab, Bathinda, Punjab, India

    Anjana Munsi

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Islam, J. (2022). Protective Effect of Quercetin, Luteolin, and Fisetin via Stimulating the p53-Mediated Signaling in Cancer. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_20-1

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  • DOI: https://doi.org/10.1007/978-981-16-1247-3_20-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-1247-3

  • Online ISBN: 978-981-16-1247-3

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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