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Emerging Role of Redox-Active Nanoceria in Cancer Therapeutics via Oxidative Stress

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

Abstract

Cancer is one of the leading causes of death throughout the world. Various conventional therapeutic techniques, such as surgery, chemotherapy, radiation therapy, immunotherapy, and hormone therapy, have been implemented to cure cancer. However, most of these therapeutic approaches possess several limitations including high costs, multidrug resistance, low response rate, lack of effective and targeted delivery of the anticancer agents, and off-target side effects. Nanotechnology has provided the opportunity to overcome these shortcomings. Among various nanoparticles, nanoceria (cerium oxide nanoparticle, CeO2NP) has emerged as a promising therapeutic agent toward cancer treatment due to its unique redox activity (Ce3+/Ce4+). As a result of this property, it acts as an antioxidant in physiological conditions, thus providing cytoprotection to normal cells from oxidative damage, whereas it acts as a pro-oxidant in acidic conditions and thus is cytotoxic toward cancer cells by generating oxidative stress. Besides, nanoceria has also been used as a carrier for targeted delivery of anticancer drugs to the specific tumor site, hence enhancing the antitumor efficacy of the drugs. In this chapter, we have discussed the possible oxidative stress-mediated anticancer mechanism of nanoceria on different cancer types. In addition, the drug delivery application of nanoceria has also been summarized to achieve synergistic anticancer effect in combination with various anticancer drugs against different types of cancers.

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Abbreviations

CeO2NP:

cerium oxide nanoparticle

Ce6:

chlorin e6

DDS:

drug delivery system

DLC:

drug loading content

DOX:

doxorubicin

EDA:

ethylenediamine

FA:

folic acid

FUDR:

floxuridine

GO:

graphene oxide

GT:

ganetespib

HA:

hyaluronic acid

HL:

hydrolysis

HT:

hydrothermal

LSL:

lactonic sophorolipid

MDDS:

multifunctional drug delivery system

MPs:

microparticles

MSN:

mesoporous silica nanoparticle

NIR:

near-infrared irradiation

NPs:

nanoparticles

NSCLC:

non-small cell lung cancer

PAA:

polyacrylic acid

PAA:

poly-allylamine

PARP:

(poly (ADP-ribose) polymerase)

PEI:

poly-ethylenimine

PSS:

sodium polystyrene sulfonate

PVP:

poly (N-vinylpyrrolidone)

Rb:

retinoblastoma

RGO:

reduced graphene oxide

ROS:

reactive oxygen species

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Authors and Affiliations

  1. School of Advanced Chemical Sciences, Faculty of Basic Sciences, Shoolini University, Solan, Himachal Pradesh, India

    Neelam Thakur

  2. Department of Chemistry, Physical Sciences, Mizoram University, Aizawl, Mizoram, India

    Joydeep Das

  3. Division of Molecular Medicine, Bose Institute, Kolkata, India

    Parames C. Sil

Authors
  1. Neelam Thakur
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  2. Joydeep Das
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  3. Parames C. Sil
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Corresponding author

Correspondence to Parames C. Sil .

Editor information

Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Department of Chemistry and Biochemistry, University of Texas, El Paso, Texas, USA

    Mahesh Narayan

  2. School of Biotechnology, KIIT Deemed to be University, Institute of Eminence, Bhubaneswar, India

    Gopal C. Kundu

  3. Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela-, Odisha, India

    Subhankar Paul

  4. Institute of Bioinformatics and Biotechnology, SavitribaiPhule Pune University, Pune, Maharastra, India

    Tuli Dey

  5. Department of Animal Biotechnology, Lala lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, India

    Minakshi Prasad Ph.D

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Thakur, N., Das, J., Sil, P.C. (2021). Emerging Role of Redox-Active Nanoceria in Cancer Therapeutics via Oxidative Stress. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_117-1

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  • DOI: https://doi.org/10.1007/978-981-16-1247-3_117-1

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  • Print ISBN: 978-981-16-1247-3

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