Abstract
Bacterial cells (gram positive and negative) utilize generalized secretory pathways such as Sec and Tat pathways that are ubiquitous to all domains of life. Sec system transports unfolded proteins while Tat system transports folded proteins. These systems result in the export of the substrate protein to extracellular environment directly in gram-positive bacteria and after passing through the periplasmic space in gram-negative bacteria. There are different secretion systems, Type I to Type IX, for translocation of proteins or effector molecules from periplasm to outside of the cell in gram-negative bacteria. These systems are Sec-dependent and Sec-independent depending upon state of the protein during secretion. In gram-positive bacteria, the protein secretion system involves special proteins, SecA2 and sortases.
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Gupta, R., Gupta, N. (2021). Protein Secretion. In: Fundamentals of Bacterial Physiology and Metabolism. Springer, Singapore. https://doi.org/10.1007/978-981-16-0723-3_8
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DOI: https://doi.org/10.1007/978-981-16-0723-3_8
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