Abstract
One of the characteristics that easily distinguish every human being is their skin complexion. The primary pigment that brings about this distinction is melanin. And just like most other physical characteristics, the degree of pigmentation is a genetically inherited factor. As is explained by the gradation of colours from very light to dark brown, it is understood that skin colour is not governed by one specific gene, rather it is a polygenic trait. Skin colour is also influenced to some extent by the environment as well, for example, sun exposure. That is to say, while genetic expression decides the basal level of melanin synthesis, exposure to ultraviolet radiation acts as a fine tuner and upregulates or downregulates this synthesis and distribution. It is known with some clarity that apart from imparting pigment to the skin, melanin also plays a photoprotective role by preventing the cellular and molecular damage caused due to UV radiations. However, lately it has been observed that melanin also has deleterious effects that arise due to its photolabile nature. This chapter focuses on the ethnic classifications of skin types based on the melanin synthesis and susceptibility of these skin types to UV-induced cancer. Further it elaborates on the genetic correlates of melanin synthesis and distribution. The chapter concludes with the molecular mechanisms that underlie both the protective and the deleterious effects of melanin.
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References
Arda O, Goksugur N et al (2014) Basic histological structure and functions of facial skin. Clin Dermatol 32(1):3–13
Moellmann G, McGuire J et al (1973) Ultrastructure and cell biology of pigment cells. Intracellular dynamics and the fine structure of melanocytes with special reference to the effects of MSH and cyclic AMP on microtubules and 10-nm filaments. J Biol Med 46(5):337–360
Tarnowski WM (1970) Ultrastructure of the epidermal melanocyte dense plate. J Invest Dermatol 55(4):265–268
Solano F (2014) Melanins: skin pigments and much more—types, structural models, biological functions, and formation routes. New J Sci 2014:498276
Breathnach AS, Nazzaro-Porro M et al (1991) Ultrastructure of melanocytes in chronically sun-exposed skin of elderly subjects. Pigment Cell Res 4(2):71–79
Brenner M, Hearing VJ (2008) The protective role of melanin against UV damage in human skin. Photochem Photobiol 84(3):539–549
Gilchrest BA, Park HY et al (1996) Mechanisms of ultraviolet light-induced pigmentation. Photochem Photobiol 63(1):1–10
Ali YH (2019) Proposed genetic classification for the skin types: Helmy's skin types classification. Plast Reconstr Surg Glob Open 7(4):e2130
Del Bino S, Duval C et al (2018) Clinical and biological characterization of skin pigmentation diversity and its consequences on UV impact. Int J Mol Sci 19(9):2668
McEvoy B, Beleza S et al (2006) The genetic architecture of normal variation in human pigmentation: an evolutionary perspective and model. Hum Mol Genet 15:176–181
Sturm RA (2009) Molecular genetics of human pigmentation diversity. Hum Mol Genet 18(R1):9–17
Sulem P, Gudbjartsson DF et al (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. Nat Genet 39(12):1443–1452
Han J, Kraft P et al (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. PLoS Genet 4(5):e1000074
Bonilla C, Boxill LA et al (2005) The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans. Hum Genet 116(5):402–406
Martin AR, Lin M et al (2017) An unexpectedly complex architecture for skin pigmentation in Africans. Cell 171(6):1340–1353
Crawford NG, Kelly DE et al (2017) Loci associated with skin pigmentation identified in African populations. Science 358(6365):8433
Norton HL, Kittles RA et al (2007) Genetic evidence for the convergent evolution of light skin in Europeans and East Asians. Mol Biol Evol 24(3):710–722
Basu Mallick C, Iliescu FM et al (2013) The light skin allele of SLC24A5 in South Asians and Europeans shares identity by descent. PLoS Genet 9(11):e1003912
Edwards M, Bigham A et al (2010) Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: further evidence of convergent evolution of skin pigmentation. PLoS Genet 6(3):e1000867
Yang Z, Zhong H et al (2016) A genetic mechanism for convergent skin lightening during recent human evolution. Mol Biol Evol 33(5):1177–1187
Markiewicz E, Idowu OC (2020) Melanogenic difference consideration in ethnic skin type: a balance approach between skin brightening applications and beneficial Sun exposure. Clin Cosmet Investig Dermatol 13:215–232
Orthaber K, Pristovnik M et al (2017) Skin cancer and its treatment: novel treatment approaches with emphasis on nanotechnology. J Nanomater 2017:2606271
Domingues B, Lopes JM et al (2018) Melanoma treatment in review. Immunotargets Ther 7:35–49
Sun X, Zhang N et al (2020) Ultraviolet radiation and melanomagenesis: from mechanism to immunotherapy. Front Oncol 10:951
Kadekaro AL, Kavanagh RJ et al (2003) Cutaneous photobiology. The melanocyte vs. the sun: who will win the final round? Pigment Cell Res 16(5):434–447
Halder RM, Bang KM (1988) Skin cancer in blacks in the United States. Dermatol Clin 6(3):397–405
Szabo G, Gerald AB et al (1969) Racial differences in the fate of melanosomes in human epidermis. Nature 222(5198):1081–1082
Kobayashi N, Nakagawa A et al (1998) Supranuclear melanin caps reduce ultraviolet induced DNA photoproducts in human epidermis. J Invest Dermatol 110(5):806–810
Hill HZ, Hill GJ (2000) UVA, pheomelanin and the carcinogenesis of melanoma. Pigment Cell Res 13(Suppl 8):140–144
Hill HZ, Li W et al (1997) Melanin: a two edged sword? Pigment Cell Res 10(3):158–161
Napolitano A, Panzella L et al (2014) Pheomelanin-induced oxidative stress: bright and dark chemistry bridging red hair phenotype and melanoma. Pigment Cell Melanoma Res 27(5):721–733
Takeuchi S, Zhang W et al (2004) Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin. Proc Natl Acad Sci US A101(42):15076–15081
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Bhattacharya, B., Chauhan, D., Singh, A.K., Chatterjee, M. (2021). Melanin Based Classification of Skin Types and Their Susceptibility to UV-Induced Cancer. In: Dwivedi, A., Tripathi, A., Ray, R.S., Singh, A.K. (eds) Skin Cancer: Pathogenesis and Diagnosis. Springer, Singapore. https://doi.org/10.1007/978-981-16-0364-8_3
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DOI: https://doi.org/10.1007/978-981-16-0364-8_3
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