Abstract
Regenerative medicine (RM) and tissue engineering (TE) are the two novel approaches that mankind can bank upon to explore new avenues in understanding the complexities of living systems and to lead the future bio-medical research. Nevertheless, the concepts of TE and RM are based on growth, regeneration, proliferation, and differentiation of cells. As such, stem cells make the core with properties to perform all the functionalities conceptualizing TE and RM. Stem cells along with biomaterials form an integral part of these approaches which underlie the healthcare research and its eventual ensuing advances. Properties, structure, composition, and functionality of biomaterials used play a key role in development of cells and tissues in TE and RM. Since, supporting material is vital for cells for regeneration/repair of tissues or in organ development, different biomaterials as scaffolds are used for the purpose. Understanding the intricate developmental process of cells to tissues to organs is vital in TE and RM. Use of different biomaterials along with various lineages of stem cells supplemented with nutrients, growth factors, etc. will help to decipher the underlying entangled mechanisms. A good understanding of the basic and advanced concepts of biomaterials and stem cells, the different methods involved, and their applications in TE and RM are of at most prerequisite to further the goal of developing functional tissues and organs. Hence, here below in this manuscript, we provided detailed insights of the concepts, methods, and applications of biomaterials and stem cells in TE and RM.
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Abbreviations
- ESC:
-
Embryonic stem cells
- iPSC :
-
Induced pluripotent stem cells
- MSC :
-
Mesenchymal stem cells
- PCL :
-
Poly (ε-caprolactone)
- PLGA :
-
Poly (lactic-co-glycolic acid)
- PLLA :
-
Poly (L-lactic acid)
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Nagarjuna, V. (2021). Biomaterials and Stem Cells in Tissue Engineering and Regenerative Medicine: Concepts, Methods, and Applications. In: Bhaskar, B., Sreenivasa Rao, P., Kasoju, N., Nagarjuna, V., Baadhe, R.R. (eds) Biomaterials in Tissue Engineering and Regenerative Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-16-0002-9_13
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