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Genomic Profiling of ADHD

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Proteins Associated with Neurodevelopmental Disorders

Part of the book series: Nutritional Neurosciences ((NN))

Abstract

The inheritance of attention-deficit hyperactivity disorder (ADHD) is more common in children and adults and therefore more research in the field of genetics was carried out. The experiments indicated that the genetic factors played a crucial role in the etiology and course of the disease. Numerous studies initially focused on the candidate genes for ADHD particularly those genes involved in the dopaminergic, noradrenergic, and serotonergic neurotransmission systems. In the recent past, the association of ADHD with the candidate genes linked to neuronal growth and plasticity, and the glutaminergic system, has been published. This chapter reviews the single-nucleotide polymorphisms found in the candidate genes and recaps the results of genome-wide association studies (GWAS). GWAS helps in the discovery of new ADHD genes in a hypothesis-free manner. The GWAS findings are redirecting the future of the ADHD research towards novel gene systems and processes. The association between genetic experts (researchers), clinicians, and statisticians is needed in the future to identify more novel ADHD genes.

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Authors and Affiliations

  1. Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, India

    Arokiasamy Justin Thenmozhi

  2. Department of Pathology, University of Arizona College of Medicine and College of Pharmacy, Tucson, AZ, USA

    Chinnasamy Dhanalakshmi

  3. Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Chidambaram, Tamil Nadu, India

    Arokiasamy Justin Thenmozhi & Thamilarasan Manivasagam

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  1. Arokiasamy Justin Thenmozhi
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  2. Chinnasamy Dhanalakshmi
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  3. Thamilarasan Manivasagam
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Editors and Affiliations

  1. Research & Policy Division, Q3CG Research Institute (QRI), Ann Arbor, MI, USA

    M. Walid Qoronfleh

  2. College of Agricultural and Marine, Sultan Qaboos University, Al Khoudh, Oman

    Musthafa Mohamed Essa

  3. Department of Pharmacology, JSS Academy of Higher Education and Research, Mysore, Karnataka, India

    Chidambaram Saravana Babu

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Justin Thenmozhi, A., Dhanalakshmi, C., Manivasagam, T. (2022). Genomic Profiling of ADHD. In: Qoronfleh, M.W., Essa, M.M., Saravana Babu, C. (eds) Proteins Associated with Neurodevelopmental Disorders. Nutritional Neurosciences. Springer, Singapore. https://doi.org/10.1007/978-981-15-9781-7_6

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