Skip to main content

Oxidative Dyshomeostasis in the Mitochondria

A Tumorigenic Etiology

  • Reference work entry
  • First Online:
Handbook of Oxidative Stress in Cancer: Mechanistic Aspects
  • 29 Accesses

Abstract

The etiology of cancer is profoundly associated with variable degrees of oxidative stress in a tissue. Mitochondria, being the paramount seat of oxidative stress generation in a cell, are actively involved in regulating the physiological facets of cancer cells. These organelles maintain a redox imbalance-derived homeostasis in neoplastic cells, which is conducive for the initiation of tumors as well as for cancer progression. Mitochondria achieve such redox imbalance in tumors by inducing oxidative stress only to a certain level, beyond which further stress can kill the cancer cells intrinsically. This chapter is aimed at elucidating the complexities of the mitochondrial paraphernalia in the etiology of cancer. This includes the tumor-associated mitochondrial alterations, such as generation of excessive oxidative stress, mitochondrial antioxidants, mitochondria-governed metabolic adaptations in the tumor microenvironment, oxidative injury to mitochondrial DNA, resistance to apoptosis, and predilection for autophagy. The chapter also explores the role of mitochondrial oxidative stress in tumor growth and metastasis. Moreover, the chapter examines a variety of mitochondrial markers for different types of cancer. A number of mitochondria-targeted cancer therapy approaches have also been reviewed in this chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 799.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 1,599.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gunjan Guha .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Singapore Pte Ltd.

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Guha, G., Bhakta-Guha, D. (2022). Oxidative Dyshomeostasis in the Mitochondria. In: Chakraborti, S., Ray, B.K., Roychoudhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-9411-3_70

Download citation

Publish with us

Policies and ethics