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Interplay Between Redox Homeostasis and Oxidative Stress in the Perspective of Ovarian and Cervical Cancer Immunopathogenesis

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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

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Abstract

Generation of reactive oxygen species (ROS) is an inevitable part of cellular metabolism that is controlled by the antioxidant defense mechanism to maintain redox homeostasis. Under external or internal stress, this redox balance gets perturbed leading to high ROS levels and thus oxidative stress. Persistent oxidative stress contributes to the neoplastic transformation of healthy tissues. Oxidative stress is a crucial factor in the process of carcinogenesis as it aids in the initiation, promotion, and progression of tumor cells. ROS stimulates the growth of cancer cells by regulating various signaling pathways and suppressing antitumor immune responses. Tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) present in the tumor inflammatory microenvironment utilize ROS to inactivate antitumor T-cell activity. Ovarian and cervical cancer are the most lethal gynecological cancers that are associated with inflammation related to oxidative stress. The standard medications for ovarian and cervical cancer treatment are surpassed by the tumor cells leading to more aggressive cancer phenotypes. The modulation of ROS levels by the action of chemotherapeutics along with immunotherapy is a potential strategy to cure cancer patients. The use of T-cell based therapy is a well-known approach for treatment of cancer. However, the efficacy of treatment is hampered by the functional inactivation of T cells when these cells enter into highly oxidative tumor microenvironment. Thus, to increase the efficacy of T-cell based therapy, the use of antioxidants to decrease the ROS levels, can prove to be a potential strategy to treat cancer.

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Authors and Affiliations

  1. Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Kolkata, India

    Saurav Kumar, Vaishali Mulchandani, Anurag Banerjee & Jayasri Das Sarma

Authors
  1. Saurav Kumar
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  2. Vaishali Mulchandani
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  3. Anurag Banerjee
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  4. Jayasri Das Sarma
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Corresponding author

Correspondence to Jayasri Das Sarma .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA

    Bimal K. Ray

  3. CSIR-Indian Institute of Chemical Biology, Kolkata, India

    Susanta Roychoudhury

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Kumar, S., Mulchandani, V., Banerjee, A., Das Sarma, J. (2022). Interplay Between Redox Homeostasis and Oxidative Stress in the Perspective of Ovarian and Cervical Cancer Immunopathogenesis. In: Chakraborti, S., Ray, B.K., Roychoudhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-9411-3_69

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