Abstract
Cancer is a grievous challenge to human health owing to a colossal heterogeneity in its etiology. Initiation of tumorigenesis is facilitated by genomic instability that, in turn, is promoted by accumulation of damage in the DNA. Oxidative stress, a chief contributor of such damage, therefore, plays a crucial role in the onset of genomic instability. By altering structural and functional integrity of DNA, oxidative stress paves a path for onset of comprehensive genomic dyshomeostasis, which snowballs into neoplastic transformation. These alterations, exhibited as the chromosomal instability, microsatellite instability, oncogenic replication stress, and epigenetic modifications, are exploited by cancer cells to effectuate unencumbered proliferation. Furthermore, oxidative stress tends to damage critical components of the endogenous cellular repair machineries that otherwise could have inhibited such anomalous progressions. In the ambit of the critical role that oxidative stress plays in governing genomic instability in different types of cancers, this chapter provides an insight into the variegated molecular mechanisms that are involved in the process. Also, the therapeutic strategies aimed at ameliorating oxidative stress to annihilate cancer cells have been discussed here. Overall, the chapter aims at highlighting the mechanistic significance of oxidative stress in orchestrating genomic instability-associated cancer progression.
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Bhakta-Guha, D., Guha, G. (2022). Oxidative Stress in Orchestrating Genomic Instability-Associated Cancer Progression. In: Chakraborti, S., Ray, B.K., Roychoudhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-9411-3_50
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DOI: https://doi.org/10.1007/978-981-15-9411-3_50
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