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Anthocyanins and Flavonols: Therapeutic Implications of Natural Compounds on Cancer

Therapeutic Implications in ROS-Induced Cancer

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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

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Abstract

Cancer stands among the main causes of death worldwide characterized by a combination of different factors which drive tumor progression and invasiveness. Oxidative stress has been shown to possess a central involvement in cancer development for promoting an imbalanced microenvironment, favoring DNA mutations and damage to biological structures. Flavonoids are naturally occurring compounds present in plant-based foods, mainly fruits and vegetables, which exhibit notable antioxidant and radical scavenging activities. Due to their biological activities and their availability in nature, anthocyanins and flavonols, one of the flavonoids subclasses, have been studied as potential anticarcinogenic agents. This chapter summarizes the main therapeutic implications of some of the most efficacious diet-derivate anthocyanidins and flavonols, and its glycosides, on cancer chemotherapy and chemoprevention.

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Acknowledgments

The authors are thankful for grants and fellowships provided by the Brazilian Agencies Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; Finance Code 001).

Conflict of Interest

None.

Author information

Author notes

  1. Charles Elias Assmann and Grazielle Castagna Cezimbra Weis share the first authorship of this chapter.

Authors and Affiliations

  1. Federal University of Santa Maria, Santa Maria, RS, Brazil

    Charles Elias Assmann, Grazielle Castagna Cezimbra Weis, Jéssica Righi da Rosa & Audrei de Oliveira Alves

  2. Federal University of Santa Catarina, Florianópolis, SC, Brazil

    Beatriz da Silva Rosa Bonadiman

  3. University of the State of Santa Catarina, Pinhalzinho, SC, Brazil

    Felipe Tecchio Borsoi

  4. Federal University of the South Border, Chapecó, SC, Brazil

    Margarete Dulce Bagatini

Authors
  1. Charles Elias Assmann
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  2. Grazielle Castagna Cezimbra Weis
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  3. Jéssica Righi da Rosa
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  4. Beatriz da Silva Rosa Bonadiman
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  5. Audrei de Oliveira Alves
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  6. Felipe Tecchio Borsoi
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  7. Margarete Dulce Bagatini
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Editor information

Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA

    Bimal K. Ray

  3. CSIR-Indian Institute of Chemical Biology, Kolkata, India

    Susanta Roychoudhury

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Assmann, C.E. et al. (2022). Anthocyanins and Flavonols: Therapeutic Implications of Natural Compounds on Cancer. In: Chakraborti, S., Ray, B.K., Roychoudhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-9411-3_139

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