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Oncologic Properties of Retinoblastoma Genes

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Advances in Vision Research, Volume III

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

Retinoblastoma is the commonest pediatric intraocular cancer across various populations. Following the “two-hit model,” both alleles are inactivated at the disease-causing gene, RB1. RB has been well studied to establish its “classical” function in regulating cell cycle progression and the transcription machinery. Recent studies have identified additional genetic factors contributing to retinoblastoma tumor development. Some of these newly identified genetic factors, including MGMT and MLH1, are well known for their roles in maintaining genome stability. On the other hand, novel functions have also been found in RB in preserving genome stability. As genome instability is a major driving force of cancer, understanding the oncologic properties of RB and other retinoblastoma related genes could improve our knowledge and disease management in retinoblastoma and other RB mutated cancers.

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Wai Kit Chu, Jason C. S. Yam, Li Jia Chen & Chi Pui Pang

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  1. Wai Kit Chu
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  2. Jason C. S. Yam
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Correspondence to Wai Kit Chu .

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Editors and Affiliations

  1. National Eye Institute, National Institutes of Health, Bethesda, MD, USA

    Gyan Prakash

  2. National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan

    Takeshi Iwata

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Chu, W.K., Yam, J.C.S., Chen, L.J., Pang, C.P. (2021). Oncologic Properties of Retinoblastoma Genes. In: Prakash, G., Iwata, T. (eds) Advances in Vision Research, Volume III. Essentials in Ophthalmology. Springer, Singapore. https://doi.org/10.1007/978-981-15-9184-6_27

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  • DOI: https://doi.org/10.1007/978-981-15-9184-6_27

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-9183-9

  • Online ISBN: 978-981-15-9184-6

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