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Application of Optogenetics in Epilepsy Research

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Optogenetics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1293))

Abstract

Epilepsy is a disease characterized by seizures arising from paroxysmal and self-limited hypersynchrony of neurons. However, the mechanism by which the normal brain develops epilepsy, which involves a chronic process of structural and morphological changes known as epileptogenesis, is not fully understood. Optogenetics involves the use of genetic engineering and optics to monitor or control nerve cell activity. Compared to classical electrophysiological experiments, the application of optogenetics in epilepsy research has many advantages because it allows selective photic stimulation of cell types and electrical observation without introducing artifacts.

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Abbreviations

AEDs:

Antiepileptic drugs

DBS:

Deep brain stimulation

GABA:

Gamma-aminobutyric acid

VNS:

Vagus nerve stimulation

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Acknowledgments

This work was supported by JSPS KAKENHI Grant Number 18 K08960, JERF TENKAN 18003 and The Clinical Research Promotion Program for Young Investigators of Tohoku University Hospital 2018.

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Authors and Affiliations

  1. Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan

    Shin-Ichiro Osawa & Teiji Tominaga

Authors
  1. Shin-Ichiro Osawa
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  2. Teiji Tominaga
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Corresponding author

Correspondence to Shin-Ichiro Osawa .

Editor information

Editors and Affiliations

  1. The Institute for Solid State Physics, The University of Tokyo, Kashiwa, Japan

    Hiromu Yawo

  2. OptoBioTechnology Research Center, Nagoya Institute of Technology, Nagoya, Japan

    Hideki Kandori

  3. National Institutes of Natural Sciences, Tokyo, Japan

    Amane Koizumi

  4. Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

    Ryoichiro Kageyama

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Osawa, SI., Tominaga, T. (2021). Application of Optogenetics in Epilepsy Research. In: Yawo, H., Kandori, H., Koizumi, A., Kageyama, R. (eds) Optogenetics. Advances in Experimental Medicine and Biology, vol 1293. Springer, Singapore. https://doi.org/10.1007/978-981-15-8763-4_39

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