Abstract
Moringa oleifera is a small- to medium-sized multipurpose tree, which grows in tropical and subtropical regions of the world. Moringa oleifera is drought-resistant, preferring regions with dry/wet climate and hence is cultivated in a wide range of habitats on a variety of soils across the world. It contains a significant value including as food, fodder, medicine, fuelwood, and fertilizer from all parts of the plant. Leaves are rich in minerals, vitamins, and other essential phytochemicals. These phytochemicals are used as conventional drugs for antioxidants, antitumor, antidiabetes, antihyperlipidemia, and as antimicrobial agents. The leaves extract is also involved in the treatment of malnutrition, augmenting breast milk in lactating mothers. The production of seeds from elongated capsule fruits is most useful in water purification. The scientific evidence provides insights on the utilization of Moringa oleifera to cure diabetes, cancer. The large-scale commercial cultivation of this species accelerates the medicinal, nutritional, and prominent pharmaceutical values.
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References
Abd El-Hack ME, Alagawany M, Elrys AS, Desoky ESM, Tolba H, Elnahal AS, Elnesr SS, Swelum AA (2018) Effect of forage Moringa oleifera L (moringa) on animal health and nutrition and its beneficial applications in soil, plants and water purification. Agric 8(9):145
Abdull Razis AF, Ibrahim MD, Kntayya SB (2014) Health benefits of Moringa oleifera. Asian Pac J Cancer Prev 15(20):8571–8576
Adebayo IA, Arsad H, Samian MR (2017) Antiproliferative effect on breast cancer (MCF7) of Moringa oleifera seed extracts. Afr J Tradit Complement Altern Med 14(2):282–287
Adeyemi OS, Elebiyo TC (2014) Moringa oleifera supplemented diets prevented nickel-induced nephrotoxicity in wistar rats. J Nutr Metab
Adisakwattana S, Chanathong B (2011) Alpha-glucosidase inhibitory activity and lipid-lowering mechanisms of Moringa oleifera leaf extract. Eur Rev Med Pharmacol Sci 15(7):803–808
Ali A, Akhtar N, Chowdhary F (2014) Enhancement of human skin facial revitalization by moringa leaf extract cream. Postepy Dermatol Alergol 31(2):71–76
Al-Malki AL, El Rabey HA (2015) The antidiabetic effect of low doses of Moringa oleifera L seeds on streptozotocin induced diabetes and diabetic nephropathy in male rats. Biomed Res Int. https://doi.org/10.1155/2015/381040
Almatrafi MM, Vergara-Jimenez M, Murillo AG, Norris GH, Blesso CN, Fernandez ML (2017) Moringa leaves prevent hepatic lipid accumulation and inflammation in Guinea pigs by reducing the expression of genes involved in lipid metabolism. Int J Mol Sci 18(7):1330. https://doi.org/10.3390/ijms18071330
Al-Zahrani AA, Ibrahim AH (2018) Changes in 2S albumin gene expression in Moringa oleifera under drought stress and expected allergenic reactivity in silico analysis. Theor Exp Plant Physiol 30(1):19–27
Anwar F, Latif S, Ashraf M, Gilani AH (2007) Moringa oleifera: a food plant with multiple medicinal uses. Phytother Res 21(1):17–25
Aronson D, Rayfield EJ (2002) How hyperglycemia promotes atherosclerosis: molecular mechanisms. Cardiovasc Diabetol 1:1): 1. https://doi.org/10.1186/1475-2840-1-1
Atawodi SE, Atawodi JC, Idakwo GA, Pfundstein B, Haubner R, Wurtele G, Bartsch H, Owen RW (2010) Evaluation of the polyphenol content and antioxidant properties of methanol extracts of the leaves, stem, and root barks of Moringa oleifera. Lam J Med Food 13(3):710–716
Augustin JM, Kuzina V, Andersen SB, Bak S (2011) Molecular activities, biosynthesis and evolution of triterpenoid saponins. Phytochemistry 72(6):435–457
Ayoola GA, Coker HA, Adesegun SA, Adepoju-Bello AA, Obaweya K, Ezennia EC, Atangbayila TO (2008) Phytochemical screening and antioxidant activities of some selected medicinal plants used for malaria therapy in southwestern Nigeria. Trop J Pharm Res 7(3):1019–1024
Bakre AG, Aderibigbe AO, Ademowo OG (2013) Studies on neuropharmacological profile of ethanol extract of Moringa oleifera leaves in mice. J Ethnopharmacol 149(3):783–789
Berkovich L, Earon G, Ron I, Rimmon A, Vexler A, Lev-Ari S (2013) Moringa oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells. BMC Complement Altern Med 13(1):212. https://doi.org/10.1186/1472-6882-13-212
Bezerra K, Silva NG, de Souza A, Sá G, de Araújo F(2016) Moringa oleifera: A new perspective for the synthesis of natural products. Mol2net 2(14): 1–5. Available on https://sciforum.net/manuscripts/5533/slides.pdf
Bischoff SC (2008) Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care 11(6):733–740
Cerf ME (2013) Beta cell dysfunction and insulin resistance. Front Endocrinol 4:37. https://doi.org/10.3389/fendo.2013.00037
Davinelli S, Bertoglio JC, Zarrelli A, Pina R, Scapagnini G (2015) A randomized clinical trial evaluating the efficacy of an anthocyanin–maqui berry extract (Delphinol®) on oxidative stress biomarkers. J Am Coll Nutr 34:28–33
Devarai LGKD (2005) Moringa Oleifera: a review on nutritive importance. Asian J Plant Sci 4:417–421
Dinkova-Kostova AT, Kostov RV (2012) Glucosinolates and isothiocyanates in health and disease. Trends Mol Med 18(6):337–347
Divi SM, BellamkondaRamesh DSK (2012) Evaluation of antidiabetic and antihyperlipedemic potential of aqueous extract of Moringa oleifera in fructose fed insulin resistant and STZ induced diabetic wistar rats: a comparative study. Asian J Pharm Clin Res 5(1):67–72
D’Souza T, Mengi SA, Hassarajani S, Chattopadhayay S (2007) Efficacy study of the bioactive fraction (F-3) of Acoruscalamus in hyperlipidemia. Indian J Pharm 39(4):196–200
Fahey JW (2005) Moringa oleifera: a review of the medical evidence for its nutritional, therapeutic, and prophylactic properties. Trees Life J 1(5):1–15
Faizi S, Siddiqui BS, Saleem R, Aftab K, Shaheen F (1998) Hypotensive constituents from the pods of Moringa oleifera. Planta Med 64(03):225–228
Ferreira PMP, Farias DF, Oliveira JTDA, Carvalho ADFU (2008) Moringa oleifera: bioactive compounds and nutritional potential. Rev Nutr 21(4):431–437
Flora SJ, Pachauri V (2011) Moringa (Moringa oleifera) seed extract and the prevention of oxidative stress. In: Nuts and seeds in health and disease prevention, pp 775–785
Förster N, Ulrichs C, Schreiner M, Müller CT, Mewis I (2015) Development of a reliable extraction and quantification method for glucosinolates in Moringa oleifera. Food Chem 166:456–464
Fuglie LJ (2005) The Moringa tree: a local solution to malnutrition. Church World Serv Senegal 5:75–83
Gandji K, Chadare FJ, Idohou R, Salako VK, Assogbadjo AE, Kakaï RG (2018) Status and utilisation of Moringa oleifera Lam: a review. Afr Crop Sci J 26(1):137–156
Ghazali HM, Mohammed AS(2011) Moringa (Moringa oleifera) seed oil: composition, nutritional aspects, and health attributes. In: Nuts and seeds in health and disease prevention, pp 787–793
Gopalakrishnan L, Doriya K, Kumar DS (2016) Moringa oleifera: a review on nutritive importance and its medicinal application. Food Sci Human Wellness 5:49–56
Guevara AP, Vargas C, Sakurai H, Fujiwara Y, Hashimoto K, Maoka T, Kozuka M, Ito Y, Tokuda H, Nishino H (1999) An antitumor promoter from Moringa oleifera lam. Mutat Res Genet Toxicol Environ Mutagen 440(2):181–188
Halaby MS, Elmetwaly EM, Omar AAA (2013) Effect of Moringa oleifera on serum lipids and kidney function of hyperlipidemic rats. J Appl Sci Res 9:5189–5198
Iqbal S, Bhanger MI (2006) Effect of season and production location on antioxidant activity of Moringa oleifera leaves grown in Pakistan. J Food Compos Anal 19(6–7):544–551
Kaneto H, Kajimoto Y, Miyagawa JI, Matsuoka TA, Fujitani Y, Umayahara Y, Hanafusa T, Matsuzawa Y, Yamasaki Y, Hori M (1999) Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. J Diabetes 48(12):2398–2406
Karadi RV, Gadge NB, Alagawadi KR, Savadi RV (2006) Effect of Moringa oleifera lam. Root-wood on ethylene glycol induced urolithiasis in rats. J Ethnopharmacol 105(1–2):306–311
Karim NAA, Ibrahim MD, Kntayya SB, Rukayadi Y, Hamid HA, Razis AFA (2016) Moringa oleifera Lam targeting chemoprevention. Asian Pac J Cancer Prev 17(8):3675–3686
Kasolo JN, Bimenya GS, Ojok L, Ochieng J, Ogwal-Okeng JW (2010) Phytochemicals and uses of Moringa oleifera leaves in Ugandan rural communities. J Med Plant Res 4:9
Khor KZ, Lim V, Moses EJ, Abdul Samad N (2018) The in vitro and in vivo anticancer properties of Moringa oleifera. Evid Based Complement Alternat Med. https://doi.org/10.1155/2018/1071243
Kumar S, Pandey AK (2013) Chemistry and biological activities of flavonoids: an overview. Sci World J. https://doi.org/10.1155/2013/162750
Lako J, Trenerry VC, Wahlqvist M, Wattanapenpaiboon N, Sotheeswaran S, Premier R (2007) Phytochemical flavonols, carotenoids and the antioxidant properties of a wide selection of Fijian fruit, vegetables and other readily available foods. Food Chem 101(4):1727–1741
Lalas S, Tsaknis J (2002) Characterization of Moringa oleifera seed oil variety" Periyakulam 1". J Food Compos Anal 15(1):65–78
Lin M, Zhang J, Chen X (2018) Bioactive flavonoids in Moringa oleifera and their health-promoting properties. J Funct Foods 47:469–479
Ma ZF, Ahmad J, Zhang H, KhanI MS (2019) Evaluation of phytochemical and medicinal properties of Moringa (Moringa oleifera) as a potential functional food. S Afr J Bot
Makkar HA, Becker K (1996) Nutrional value and antinutritional components of whole and ethanol extracted Moringa oleifera leaves. Anim Feed Sci Technol 63(1–4):211–228
Manzoor M, Anwar F, Iqbal T, Bhanger MI (2007) Physico-chemical characterization of Moringa concanensis seeds and seed oil. J Am Chem Soc 84(5):413–419
Mbikay M (2012) Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: a review. Front Pharmacol 3:24. https://doi.org/10.3389/fphar.2012.00024
Mishra G, Singh P, Verma R, Kumar S, Srivastav S, Jha KK, Khosa RL (2011) Traditional uses, phytochemistry and pharmacological properties of Moringa oleifera plant: an overview. Der Pharm Lett 3(2):141–164
Muangnoi C, Chingsuwanrote P, Praengamthanachoti P, Svasti S, Tuntipopipat S (2012) Moringa oleifera pod inhibits inflammatory mediator production by lipopolysaccharide-stimulated RAW 264.7 murine macrophage cell lines. Inflammation 35(2):445–455
Murillo AG, Fernandez ML (2017) The relevance of dietary polyphenols in cardiovascular protection. Curr Pharm Des 23(17):2444–2452
Ouédraogo M, Lamien-Sanou A, Ramdé N, Ouédraogo AS, Ouédraogo M, Zongo SP, Goumbri O, Duez P, Guissou PI (2013) Protective effect of Moringa oleifera leaves against gentamicin-induced nephrotoxicity in rabbits. Exp Toxicol Pathol 65(3):335–339
Owusu D, Ellis WO, Oduro I (2008) Nutritional potential of two leafy vegetables: Moringa oleifera and Ipomoea batatas leaves. Sci Res Essay 3(2):57–60
Oyedepo TA, Babarinde SO, Ajayeoba TA (2013) Evaluation of anti-hyperlipidemic effect of aqueous leaves extract of Moringa oleifera in alloxan induced diabetic rats. Int J Biochem Res Rev 3(3):162–170
Panda S, Kar A, Sharma P, Sharma A (2013) Cardioprotective potential of N, α-l-rhamnopyranosylvincosamide, an indole alkaloid, isolated from the leaves of Moringa oleifera in isoproterenol induced cardiotoxic rats: in vivo and in vitro studies. Bioorg Med Chem Lett 23(4):959–962
Pandey A, Pradheep K, Gupta R, Nayar ER, Bhandari DC (2011) Drumstick tree’(Moringa oleifera lam.): a multipurpose potential species in India. Genet Resour Crop Evol 58(3):453–460
Pari L, Kumar NA (2002) Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. J Med Food 5(3):171–177
Posmontier B (2011) The medicinal qualities of Moringa oleifera. Holist Nurs Pract 25(2):80–87
Prabhu K, Murugan K, Nareshkumar A, Ramasubramanian N, Bragadeeswaran S (2011) Larvicidal and repellent potential of Moringa oleifera against malarial vector, Anopheles stephensi Liston (Insecta: Diptera: Culicidae). Asian Pac J Trop Biomed 1(2):124–129
Prentki M, Nolan CJ (2006) Islet β cell failure in type 2 diabetes. J Clin Invest 116(7):1802–1812
Richter N, Siddhuraju P, Becker K (2003) Evaluation of nutritional quality of moringa (Moringa oleifera lam.) leaves as an alternative protein source for Nile tilapia (Oreochromisniloticus L.). Aquaculture 217(1–4):599–611
Rockwood JL, Anderson BG, Casamatta DA (2013) Potential uses of Moringa oleifera and an examination of antibiotic efficacy conferred by M. oleifera seed and leaf extracts using crude extraction techniques available to underserved indigenous populations. Phytother Res 3(2):61–71
Sadek KM, Abouzed TK, Abouelkhair R, Nasr S (2017) The chemo-prophylactic efficacy of an ethanol Moringa oleifera leaf extract against hepatocellular carcinoma in rats. Pharm Biol 55(1):1458–1466
Sahakitpichan P, Mahidol C, Disadee W, Ruchirawat S, Kanchanapoom T (2011) Unusual glycosides of pyrrole alkaloid and 4′-hydroxyphenylethanamide from leaves of Moringa oleifera. Phytochemistry 72(8):791–795
Sánchez-Machado DI, Núñez-Gastélum JA, Reyes-Moreno C, RamÃrez-Wong B, López-Cervantes J (2010) Nutritional quality of edible parts of Moringa oleifera. Food Anal Methods 3(3):175–180
Sandeep G, Anitha T, Vijayalatha KR, Sadasakthi A (2019) Moringa for nutritional security (Moringa oleifera lam.). Int J Bot Stud 4:21–24
Sharifudin SA, Fakurazi S, Hidayat MT, Hairuszah I, ArisMohdMoklas M, Arulselvan P (2013) Therapeutic potential of Moringa oleifera extracts against acetaminophen-induced hepatotoxicity in rats. Pharm Biol 51(3):279–288
Siasos G, Tousoulis D, Tsigkou V, Kokkou E, Oikonomou E, Vavuranakis M, Basdra EK, Papavassiliou AG, Stefanadis C (2013) Flavonoids in atherosclerosis: an overview of their mechanisms of action. Curr Med Chem 20(21):2641–2660
Siddhuraju P, Becker K (2003) Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera lam.) leaves. J Agric Food Chem 51(8):2144–2155
Sikder K, Sinha MA, Das NI, Das DK, Datta SA, Dey SA (2013) Moringa oleifera leaf extract prevents in vitro oxidative DNA damage. Asian J Pharm Clin Res 6(2):157–161
Singh RG, Negi PS, Radha C (2013) Phenolic composition, antioxidant and antimicrobial activities of free and bound phenolic extracts of Moringa oleifera seed flour. J Funct Foods 5(4):1883–1891
Sowmya R, Sachindra NM (2012) Evaluation of antioxidant activity of carotenoid extract from shrimp processing byproducts by in vitro assays and in membrane model system. Food Chem 134(1):308–314
Sultana B, Anwar F (2008) Flavonols (kaempeferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants. Food Chem 108(3):879–884
Sultana S, Akram M, Shah SMA, Ayaz S, Rehman MUR, Ahmad H, Chishti AW (2018) Moringa oleifera Lam. A miraculous medic inal plant. Review. Pak J Med Biol Sci 2(1):60–63
Swatią AK, Kumari C, Ali A, Garg P, Thakur P, Attri C, Kulshrestha S (2018) Moringa Oleifera-A Never Die Tree: An Overview. Asian J Pharm Clin Res 11(12):57–65
Teixeira EMB, Carvalho MRB, Neves VA, Silva MA, Arantes-Pereira L (2014) Chemical characteristics and fractionation of proteins from Moringa oleifera lam. Leaves. Food Chem 147:51–54
Tejas GH, Umang JH, Payal BN, Tusharbinu DR, Pravin TR (2012) A panoramic view on pharmacognostic, pharmacological, nutritional, therapeutic and prophylactic values of Moringa oleifera lam. Int Res J Pharm 3:1–7
Tian X, Tang H, Lin H, Cheng G, Wang S, Zhang X (2013) Saponins: the potential chemotherapeutic agents in pursuing new anti-glioblastoma drugs. Mini Rev J Med Chem 13(12):1709–1724
Toma A, Makonnen E, Debella A, Tesfaye B (2012) Antihyperglycemic effect on chronic administration of butanol fraction of ethanol extract of moringastenopetala leaves in alloxan induced diabetic mice. Asian Pac J Trop Biomed 2(3):606–610
Uphadek B, Shinkar DM, Patil PB, Saudagar RB (2018) Moringa oleifera as a pharmaceutical excipient. Int J Curr Pharm Res 10:13–16
Vergara-Jimenez M, Almatrafi MM, Fernandez ML (2017) Bioactive components in Moringa oleifera leaves protect against chronic disease. Antioxidants 6(4):91
Wu ZY, Raven PH (2001) Flora of China, vol 8. Missouri Botanical Garden Press
Yalew TA, Mekonnen Y, Retta N (2019) Comparison of total phenolic content, free radical scavenging potential and antihyperglycemic condition from leaves extract of Moringa stenopetala and Moringa oleifera. Ethio J Pub Health Nutr:20–27
Yanishlieva-Maslarova NV, Heinonen IM (2001) Sources of natural antioxidants: vegetables, fruits, herbs, spices and tea. In: Pokorny J, Yanishlieva N, Gordon M (eds) Antioxidants in Food- Practical Application. Woodhead Publishing, Cambridge, pp 210–263
Zheng W, Wang SY (2001) Antioxidant activity and phenolic compounds in selected herbs. J Agric Food Chem 49(11):5165–5170
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Kumar, V., Kumar, A., Nayik, G.A., Rafiq, S.M. (2020). Drum Stick (Moringa oleifera). In: Nayik, G.A., Gull, A. (eds) Antioxidants in Vegetables and Nuts - Properties and Health Benefits. Springer, Singapore. https://doi.org/10.1007/978-981-15-7470-2_13
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