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Crosslinking Strategies to Develop Hydrogels for Biomedical Applications

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Nano Hydrogels

Part of the book series: Gels Horizons: From Science to Smart Materials ((GHFSSM))

Abstract

Hydrogels can be defined as the networks of either chemically or physically crosslinked hydrophilic polymers containing large amounts of water when hydrated. They are usually used as biomaterials for various applications in the biomedical field. These applications vary from 3D cell culture and drug delivery to tissue engineering and regenerative medicine. The most important step in the development of hydrogel-based biomaterials is to make them stable under application conditions. Crosslinking of polymer chains using various approaches is utilized to stabilize the hydrogels and make them appropriate biomaterials. Mechanical and swelling characteristics of the developed materials mainly depend on the crosslinking density. Depending upon the specific requirements, different crosslinking strategies can be adopted. This chapter covers the available methods of crosslinking of polymers and preparing hydrogels. It also provides some of the advantages and disadvantages of each approach along with potential applications.

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Acknowledgements

This article was made possible by the NPRP9-144-3-021 grant funded by Qatar National Research Fund (a part of Qatar Foundation). The statements made here are the sole responsibility of authors.

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Authors and Affiliations

  1. Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha, Qatar

    Robin Augustine, Alap Ali Zahid, Syed Raza Ur Rehman, Rashid Ahmed & Anwarul Hasan

  2. Biomedical Research Center (BRC), Qatar University, Doha, Qatar

    Robin Augustine, Hashim Alhussain, Alap Ali Zahid, Syed Raza Ur Rehman, Rashid Ahmed & Anwarul Hasan

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  1. Robin Augustine
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  2. Hashim Alhussain
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  3. Alap Ali Zahid
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Correspondence to Robin Augustine .

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  1. Mahatma Gandhi University, Kottayam, Kerala, India

    Jiya Jose

  2. Mahatma Gandhi University, Kottayam, Kerala, India

    Sabu Thomas

  3. School of Aerospace, Cranfield University, Cranfield, UK

    Vijay Kumar Thakur

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Augustine, R., Alhussain, H., Zahid, A.A., Raza Ur Rehman, S., Ahmed, R., Hasan, A. (2021). Crosslinking Strategies to Develop Hydrogels for Biomedical Applications. In: Jose, J., Thomas, S., Thakur, V.K. (eds) Nano Hydrogels. Gels Horizons: From Science to Smart Materials. Springer, Singapore. https://doi.org/10.1007/978-981-15-7138-1_2

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