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Synthesis, Structural Modification and Physiochemical Response of Chitosan Built Nanohydrogel for Control Drug Delivery Applications

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Nano Hydrogels

Part of the book series: Gels Horizons: From Science to Smart Materials ((GHFSSM))

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Abstract

The present chapter explains the progressive synthesis, structural modification and physicochemical response of chitosan built hydrogel for controlled drug delivery applications. The name chitosan built referred to the hydrogel where chitosan can be used as the main component in addition to other monomers. An overview of hydrogel classification, processing, drug loading and release mechanism is highly stressed to discover the production of in-situ gelling system and their functionalization with induced sensitivity (hydrophilicity, hydrophobicity, glucose sensing and self-assembling) for the controlled release of versatile hydrophilic and hydrophobic drugs. The detailed chemistry of various stimuli-responsive hydrogel in biomedical and pharmaceutical applications has been clarified to state of the art of physicochemical responses at physiological conditions. Particular attention is paid to stimuli, including glucose, pH, temperature, ionic strength and urea-responsive hydrogel at physiological conditions. The use of chitosan built hydrogel as a controlled drug delivery system is not only limited to structure–property–relationship but needs a fundamental understanding in terms of chemical, thermal, morphological, optical and interfacial properties. These areas are addressed in terms of synthesis of chitosan built hydrogel, the respective functionalization with induced moieties along with detailed characterization and physicochemical responses for controlled drug delivery applications.

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Acknowledgments

The authors would like to acknowledge Universiti Sains Malaysia (USM) for sponsoring this research under Grant RUI 1001/PBAHAN/8014047.

Dr. Fatima Javd also acknowledge the Higher Commission (HEC) Pakistan, for providing a platform under IPFP program to accomplish this research at Shaheed Benazir Bhutto Women Univrsity Peshawar, Pakistan.

Author information

Authors and Affiliations

  1. School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, Seri Ampangan, 14300, Nibong Tebal, Pulau Pinang, Malaysia

    Faheem Ullah, Fatima Javed & Hazizan Md. Akil

  2. Institute of Chemical Sciences, University of Peshawar, Peshawar, 25120, KPK, Pakistan

    Faheem Ullah

  3. Department of Chemistry, Shaheed Benazir Bhutto Women University, Charssada Road, Peshawar, 25000, Larama, Pakistan

    Fatima Javed

Authors
  1. Faheem Ullah
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  2. Fatima Javed
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  3. Hazizan Md. Akil
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Corresponding author

Correspondence to Hazizan Md. Akil .

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Editors and Affiliations

  1. Mahatma Gandhi University, Kottayam, Kerala, India

    Jiya Jose

  2. Mahatma Gandhi University, Kottayam, Kerala, India

    Sabu Thomas

  3. School of Aerospace, Cranfield University, Cranfield, UK

    Vijay Kumar Thakur

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Ullah, F., Javed, F., Akil, H.M. (2021). Synthesis, Structural Modification and Physiochemical Response of Chitosan Built Nanohydrogel for Control Drug Delivery Applications. In: Jose, J., Thomas, S., Thakur, V.K. (eds) Nano Hydrogels. Gels Horizons: From Science to Smart Materials. Springer, Singapore. https://doi.org/10.1007/978-981-15-7138-1_15

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