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Prevention of Sudden Cardiac Death

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Sudden Death

Abstract

Sudden death refers to death that occurs unexpectedly within 6 h of the onset of symptoms and in a normal state of health before. Mortality from sudden cardiac death (SCD) exceed the combined mortality of all major cancers. SCD mostly occurs outside the hospital, and most of them are asymptomatic before the onset of event. SCD has the characteristics of burstiness and unpredictability. The out-of-hospital cardiac arrest survival chain emphasizes timely identification and call for help, mainly chest compressions, defibrillation as soon as possible, and waiting for the professional team to transfer to the hospital as soon as possible after arriving. The hospital cardiac arrest survival chain emphasizes strengthening monitoring, establishing a rapid response system, and multidisciplinary and multi-team collaboration. SCD prevention should focus on high-risk populations. Efforts are made to help patients remove the etiology, take effective measures to control risk factors, detect changes in the condition of high-risk patients, and reduce the incidence of SCD.

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References

  1. Kuriachan VP, Sumner GL, Mitchell LB. Sudden cardiac death. Curr Probl Cardiol. 2015;40(4):133–200.

    Article  PubMed  Google Scholar 

  2. Tonnis T, Tack C, Kuck KH. Sudden cardiac death in athletes and its prevention. Herz. 2015;40(3):379–85.

    Article  CAS  PubMed  Google Scholar 

  3. Al Khatib SM, Sanders GD, Carlson M, et al. Preventing tomorrow’s sudden cardiac death today:dissemination of effective therapies for sudden cardiac death prevention. Am Heart J. 2008;156(4):613–22.

    Article  Google Scholar 

  4. Priori SG, Blomstrom-Lundqvist C, Mazzanti A, et al. 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2015;36(41):2793–867.

    Article  PubMed  Google Scholar 

  5. Krokhaleva Y, Vaseghi M. Update on prevention and treatment of sudden cardiac arrest. Trends Cardiovasc Med. 2019;29(7):394–400.

    Article  PubMed  Google Scholar 

  6. Al-Khatib SM, Yancy CW, Solis P, et al. 2016 AHA/ACC clinical performance and quality measures for prevention of sudden cardiac death. J Am Coll Cardiol. 2017;69(6):712–44.

    Article  PubMed  Google Scholar 

  7. Estes NAM. Predicting and preventing sudden cardiac death. Circulation. 2011;124(5):651–6.

    Article  PubMed  Google Scholar 

  8. Zhang S. Sudden cardiac death in China: current status and future perspectives. Europace. 2015;17(Suppl 2):ii14–8.

    Article  PubMed  Google Scholar 

  9. Jazayeri MA, Emert MP. Sudden cardiac death: who is at risk? Med Clin North Am. 2019;103(5):913–30.

    Article  PubMed  Google Scholar 

  10. Winkel BG, Jabbari R, Tfelt-Hansen J. How to prevent SCD in the young? Int J Cardiol. 2017;237:6–9.

    Article  PubMed  Google Scholar 

  11. Bergau L, Seegers J, Zabel M. Sex differences in ICD benefit. J Electrocardiol. 2014;47(6):869–73.

    Article  PubMed  Google Scholar 

  12. Wong CX, Brown A, Lau DH, et al. Epidemiology of sudden cardiac death: global and regional perspectives. Heart Lung Circ. 2019;28(1):6–14.

    Article  PubMed  Google Scholar 

  13. Goyal V, Jassal DS, Dhalla NS. Pathophysiology and prevention of sudden cardiac death. Can J Physiol Pharmacol. 2016;94(3):237–44.

    Article  CAS  PubMed  Google Scholar 

  14. Wasfy MM, Hutter AM, Weiner RB. Sudden cardiac death in athletes. Methodist Debakey Cardiovasc J. 2016;12(2):76–80.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Morin DP, Homoud MK, Estes NAM 3rd. Prediction and prevention of sudden cardiac death. Card Electrophysiol Clin. 2017;9(4):631–8.

    Article  PubMed  Google Scholar 

  16. Sara JD, Eleid MF, Gulati R, Holmes DR Jr. Sudden cardiac death from the perspective of coronary artery disease. Mayo Clin Proc. 2014;89(12):1685–98.

    Article  PubMed  Google Scholar 

  17. Magi S, Lariccia V, Maiolino M, Amoroso S, Gratteri S. Sudden cardiac death: focus on the genetics of channelopathies and cardiomyopathies. J Biomed Sci. 2017;24(1):56.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  18. Kruska M, El-Battrawy I, Behnes M, Borggrefe M, Akin I. Biomarkers in cardiomyopathies and prediction of sudden cardiac death. Curr Pharm Biotechnol. 2017;18(6):472–81.

    Article  CAS  PubMed  Google Scholar 

  19. Calkins H, Corrado D, Marcus F. Risk stratification in arrhythmogenic right ventricular cardiomyopathy. Circulation. 2017;136(21):2068–82.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Haude M. Management von Herzklappenerkrankungen: ESC/EACTS-Leitlinie 2017 [Management of valvular heart disease: ESC/EACTS guidelines 2017]. Herz. 2017;42(8):715–20.

    Article  CAS  PubMed  Google Scholar 

  21. Mrsic Z, Hopkins SP, Antevil JL, Mullenix PS. Valvular heart disease. Prim Care. 2018;45(1):81–94.

    Article  PubMed  Google Scholar 

  22. Iung B, Vahanian A. Epidemiology of acquired valvular heart disease. Can J Cardiol. 2014;30(9):962–70.

    Article  PubMed  Google Scholar 

  23. Abriel H, Rougier JS, Jalife J. Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death. Circ Res. 2015;116(12):1971–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Rabinstein AA. Sudden cardiac death. Handb Clin Neurol. 2014;119:19–24.

    Article  PubMed  Google Scholar 

  25. Schmied C, Borjesson M. Sudden cardiac death in athletes. J Intern Med. 2014;275(2):93–103.

    Article  CAS  PubMed  Google Scholar 

  26. Shenasa M, Shenasa H. Hypertension, left ventricular hypertrophy, and sudden cardiac death. Int J Cardiol. 2017;237:60–3.

    Article  PubMed  Google Scholar 

  27. Shah M. Hypertrophic cardiomyopathy. Cardiol Young. 2017;27(S1):S25–30.

    Article  PubMed  Google Scholar 

  28. Nolan JP. International CPR guidelines-perspective in CPR. Best Pract Res Clin Anaesthesiol. 2013;27(3):317–25.

    Article  PubMed  Google Scholar 

  29. Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society [published correction appears in heart rhythm. 2018 Sep 26]. Heart Rhythm. 2018;15(10):e190–252.

    Article  PubMed  Google Scholar 

  30. Neumar RW, Shuster M, Callaway CW, et al. Part 1: executive summary: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2015;132(18 Suppl 2):S315–67.

    PubMed  Google Scholar 

  31. Idris AH, Guffey D, Pepe PE, et al. Chest compression rates and survival following out-of-hospital cardiac arrest. Crit Care Med. 2015;43(4):840–8.

    Article  PubMed  Google Scholar 

  32. Ringh M, Rosenqvist M, Hollenberg J, et al. Mobile-phone dispatch of laypersons for CPR in out-of-hospital cardiac arrest. N Engl J Med. 2015;372(24):2316–25.

    Article  CAS  PubMed  Google Scholar 

  33. Smith CM, Wilson MH, Ghorbangholi A, et al. The use of trained volunteers in the response to out-of-hospital cardiac arrest – the GoodSAM experience. Resuscitation. 2017;121:123–6.

    Article  PubMed  Google Scholar 

  34. Moler FW, Silverstein FS, Holubkov R, et al. Therapeutic hypothermia after in-hospital cardiac arrest in children. N Engl J Med. 2017;376(4):318–29.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Sandroni C, Nolan J, Cavallaro F, Antonelli M. In-hospital cardiac arrest: incidence, prognosis and possible measures to improve survival. Intensive Care Med. 2007;33(2):237–45.

    Article  PubMed  Google Scholar 

  36. Andersen LW, Holmberg MJ, Berg KM, Donnino MW, Granfeldt A. In-hospital cardiac arrest: a review. JAMA. 2019;321(12):1200–10.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Fishman GI, Chugh SS, Dimarco JP, et al. Sudden cardiac death prediction and prevention: report from a National Heart, lung, and blood institute and Heart Rhythm Society workshop. Circulation. 2010;122(22):2335–48.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Huis In’t Veld MA, Allison MG, Bostick DS, et al. Ultrasound use during cardiopulmonary resuscitation is associated with delays in chest compressions. Resuscitation. 2017;119:95–8.

    Article  Google Scholar 

  39. John RM, Tedrow UB, Koplan BA, et al. Ventricular arrhythmias and sudden cardiac death. Lancet. 2012;380(9852):1520–9.

    Article  PubMed  Google Scholar 

  40. Atkinson P, Bowra J, Milne J, et al. International Federation for Emergency Medicine Consensus Statement: sonography in hypotension and cardiac arrest (SHoC): an international consensus on the use of point of care ultrasound for undifferentiated hypotension and during cardiac arrest. CJEM. 2017;19(6):459–70.

    Article  PubMed  Google Scholar 

  41. Steiger HV, Rimbach K, Muller E, et al. Focused emergency echocardiography: lifesaving tool for a 14-year-old girl suffering out-of-hospital pulseless electrical activity arrest because of cardiac tamponade. Eur J Emerg Med. 2009;16(2):103–5.

    Article  PubMed  Google Scholar 

  42. Chowdhury MA, Moza A, Siddiqui NS, et al. Emergent echocardiography and extracorporeal membrane oxygenation: lifesaving in massive pulmonary embolism. Heart Lung. 2015;44(4):344–6.

    Article  PubMed  Google Scholar 

  43. Cao ZP, Xue JJ, Zhang Y, et al. Differential expression of B-type natriuretic peptide between left and right ventricles, with particular regard to sudden cardiac death. Mol Med Rep. 2017;16(4):4763–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Jappar IA, Chua T, Htoo MM, et al. Diagnosis of anomalous origin and course of coronary arteries using non-contrast cardiac CT scan and detection features. J Cardiovasc Comput Tomogr. 2012;5:335–45.

    Article  Google Scholar 

  45. Deniz A, Demir M. Comments on 2015 ESC guidelines for the Management of Patients with ventricular arrhythmias and the prevention of sudden cardiac death. Turk Kardiyol Dern Ars. 2016;44(1):9–14.

    PubMed  Google Scholar 

  46. Podriguez-Manero M, Barrio-Lopez MT. Primary prevention of sudden death in patients with valvular cardiomyopathy. Rev Esp Cardiol (Engl Ed). 2016;69(3):272–8.

    Article  Google Scholar 

  47. Tsuji Y, Ishikawa T, Makiya N. Molecular mechanisms of heart failure progression associated with implantable cardioverter-defibrillator shocks for ventricular tachyarrhythmias. J Arrhythmia. 2014;30(4):235–41.

    Article  Google Scholar 

  48. Wyllie J, Perlman JM, Kattwinkel J, et al. Part 7: Neonatal resuscitation: 2015 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation. 2015;95:e169–201.

    Article  PubMed  Google Scholar 

  49. Finn JC, Bhanji F, Lockey A, et al. Part 8:Education, implementation, and teams: 2015 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation. 2015;95:e203–24.

    Article  PubMed  Google Scholar 

  50. Peck KY, Lim YZ, Hopper I, et al. Medical therapy versus implantable cardioverter-defibrillator in preventing sudden cardiac death in patients with left ventricular systolic dysfunction and heart failure: a meta-analysis of >35000 patients. Int J Cardiol. 2014;173(2):197–203.

    Article  PubMed  Google Scholar 

  51. Chrispin J, Martin SS, Hasan RK, Joshi PH, Minder CM, McEvoy JW, Kohli P, Johnson AE, Wang L, Blaha MJ, Blumenthal RS. Landmark lipid-lowering trials in the primary prevention of cardiovascular disease. Clin Cardiol. 2013;36:516–23.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Goldberger JJ, Subacius H, Schaechter A, Howard A, Berger R, Shalaby A, Levine J, Kadish AH, DEFINITE Investigators. Effects of statin therapy on arrhythmic events and survival in patients with nonischemic dilated cardiomyopathy. J Am Coll Cardiol. 2006;48:1228–33.

    Article  CAS  PubMed  Google Scholar 

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Chai, Y., Shou, S., Gui, Y. (2021). Prevention of Sudden Cardiac Death. In: Zhu, H. (eds) Sudden Death. Springer, Singapore. https://doi.org/10.1007/978-981-15-7002-5_11

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  • DOI: https://doi.org/10.1007/978-981-15-7002-5_11

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