Abstract
Macro-autophagy (herein referred to as autophagy) is considered a major degradation pathway for damaged organelles, aggregate-prone proteins, and pathogens. There is substantial evidence stating that dysfunctional autophagy is the cause of the manifestation of multifarious degenerative diseases and cancer. Xenobiotics (here, the known group I carcinogens), substances considered foreign to the human body, are associated with inciting multiple stresses such as the endoplasmic reticulum (ER) stress, mitochondrial stress, and dysfunctional lysosome. Furthermore, autophagy exhibits a dichotomous role in cancer, although a detailed description of the modulation of autophagy by the known important carcinogens is provided only by a limited number of reports. The pro-tumorigenic role of carcinogen-induced autophagy/mitophagy has been explored which maintains homeostasis in cancer. On the contrary, the association of carcinogens with the induction of autophagic cell death has been reported. In addition, certain xenobiotics for protecting cells through dampening of necrosis, inflammation, and maintenance of genome integrity have been proposed. So far, only a few studies exploring the xenobiotic-associated autophagy modulation, both in vitro and in vivo, have been reported. The synergistic effect of environmental carcinogens in relation to autophagy has been explored, although quite little was discovered. Besides describing autophagy modulation by xenobiotics in the normal cells, there are reports illuminating how autophagy modulation could be utilized as an effective therapeutic approach for the impediment of carcinogenesis and to rescue cells from cytotoxicity. In addition, the application of chemopreventive compounds for autophagy modulation mitigating cellular toxicity and carcinogenesis have been described to achieve a safer and healthier human life.
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References
Aggarwal S, Mannam P, Zhang J (2016) Differential regulation of autophagy and mitophagy in pulmonary diseases. Am J Physiol Lung Cell Mol Physiol 311:L433–L452
Ahmad T, Sundar IK, Lerner CA, Gerloff J, Tormos AM, Yao H, Rahman I (2015) Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease. FASEB J 29:2912–2929
Amaravadi RK, Yu D, Lum JJ, Bui T, Christophorou MA, Evan GI, Thomas-Tikhonenko A, Thompson CB (2007) Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 117:326–336
Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Vinodhkumar R, Devaki T (2008) Capsaicin modulates pulmonary antioxidant defense system during benzo(a)pyrene-induced lung cancer in Swiss albino mice. Phytother Res 22:529–533
Androutsopoulos VP, Tsatsakis AM, Spandidos DA (2009) Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention. BMC Cancer 9:187
Ansari MA, Raish M, Ahmad A, Alkharfy KM, Ahmad SF, Attia SM, Alsaad AMS, Bakheet SA (2017) Sinapic acid ameliorate cadmium-induced nephrotoxicity: in vivo possible involvement of oxidative stress, apoptosis, and inflammation via NF-κB downregulation. Environ Toxicol Pharmacol 51:100–107
Arenas-Huertero F, Zaragoza-Ojeda M, Sánchez-Alarcón J, Milić M, Šegvić Klarić M, Montiel-González JM, Valencia-Quintana R (2019) Involvement of Ahr pathway in toxicity of aflatoxins and other mycotoxins. Front Microbiol 10:2347
Ashoor R, Yafawi R, Jessen B, Lu S (2013) The contribution of lysosomotropism to autophagy perturbation. PLoS One 8:e82481
Ashrafizadeh M, Ahmadi Z, Farkhondeh T, Samarghandian S (2019) Back to nucleus: combating with cadmium toxicity using Nrf2 signaling pathway as a promising therapeutic target. Biol Trace Elem Res. https://doi.org/10.1007/s12011-019-01980-4
Ba Q, Li J, Huang C, Qiu H, Li J, Chu R, Zhang W, Xie D, Wu Y, Wang H (2015) Effects of benzo[a]pyrene exposure on human hepatocellular carcinoma cell angiogenesis, metastasis, and NF-κB signaling. Environ Health Perspect 123:246–254
Bansal S, Leu AN, Gonzalez FJ, Guengerich FP, Chowdhury AR, Anandatheerthavarada HK, Avadhani NG (2014) Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction. J Biol Chem 289:9936–9951
Barrett JC (1993) Mechanisms of multistep carcinogenesis and carcinogen risk assessment. Environ Health Perspect 100:9–20
Bartholomeusz C, Gonzalez-Angulo AM (2012) Targeting the PI3K signaling pathway in cancer therapy. Expert Opin Ther Targets 16:121–130
Bassi DE, Cenna J, Zhang J, Cukierman E, Klein-Szanto AJ (2015) Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6). Mol Carcinog 54:1122–1131
Ben-Sahra I, Howell JJ, Asara JM, Manning BD (2013) Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science 339:1323–1328
Bhutia SK, Mukhopadhyay S, Sinha N, Das DN, Panda PK, Patra SK, Maiti TK, Mandal M, Dent P, Wang XY, Das SK, Sarkar D, Fisher PB (2013) Autophagy: cancer’s friend or foe? Adv Cancer Res 118:61–95
Biagioli M, Pifferi S, Ragghianti M, Bucci S, Rizzuto R, Pinton P (2008) Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis. Cell Calcium 43:184–195
Birkett N, Al-Zoughool M, Bird M, Baan RA, Zielinski J, Krewski D (2019) Overview of biological mechanisms of human carcinogens. J Toxicol Environ Health B Crit Rev 22:288–359
Biswas G, Srinivasan S, Anandatheerthavarada HK, Avadhani NG (2008) Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling. Proc Natl Acad Sci U S A 105:186–191
Bolt AM, Zhao F, Pacheco S, Klimecki WT (2012) Arsenite-induced autophagy is associated with proteotoxicity in human lymphoblastoid cells. Toxicol Appl Pharmacol 264:255–261
Boya P, González-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, Métivier D, Meley D, Souquere S, Yoshimori T, Pierron G, Codogno P, Kroemer G (2005) Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 25:1025–1040
Bruick RK, McKnight SL (2001) A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294:1337–1340
Cagnol S, Chambard JC (2010) ERK and cell death: mechanisms of ERK-induced cell death—apoptosis, autophagy and senescence. FEBS J 277:2–21
Casey SC, Vaccari M, Al-Mulla F, Al-Temaimi R, Amedei A, Barcellos-Hoff MH, Brown DG, Chapellier M, Christopher J, Curran CS, Forte S, Hamid RA, Heneberg P, Koch DC, Krishnakumar PK, Laconi E, Maguer-Satta V, Marongiu F, Memeo L, Mondello C, Raju J, Roman J, Roy R, Ryan EP, Ryeom S, Salem HK, Scovassi AI, Singh N, Soucek L, Vermeulen L, Whitfield JR, Woodrick J, Colacci A, Bisson WH, Felsher DW (2015) The effect of environmental chemicals on the tumor microenvironment. Carcinogenesis 1:160–183
Chang JY, Yi HS, Kim HW, Shong M (2017) Dysregulation of mitophagy in carcinogenesis and tumor progression. Biochim Biophys Acta Bioenerg 1858:633–640
Chargui A, Zekri S, Jacquillet G, Rubera I, Ilie M, Belaid A, Duranton C, Tauc M, Hofman P, Poujeol P, El May MV, Mograb B (2011) Cadmium-induced autophagy in rat kidney: an early biomarker of subtoxic exposure. Toxicol Sci 121:31–42
Chen ZH, Lam HC, Jin Y, Kim HP, Cao J, Lee SJ, Ifedigbo E, Parameswaran H, Ryter SW, Choi AM (2010) Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema. Proc Natl Acad Sci U S A 107:18880–18885
Chen RJ, Siao SH, Hsu CH, Chang CY, Chang LW, Wu CH, Lin P, Wang YJ (2014) TCDD promotes lung tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways. PLoS One 9:e99586
Chen ZH, Wu YF, Wang PL, Wu YP, Li ZY, Zhao Y, Zhou JS, Zhu C, Cao C, Mao YY, Xu F, Wang BB, Cormier SA, Ying SM, Li W, Shen HH (2019a) Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium. Autophagy 12:297–311
Chen W, Wang Q, Xu X, Saxton B, Tessema M, Leng S, Choksi S, Belinsky SA, Liu ZG, Lin Y (2019b) Vasorin/ATIA promotes cigarette smoke-induced transformation of human bronchial epithelial cells by suppressing autophagy-mediated apoptosis. Transl Oncol 13:32–41
Chowdhury R, Chatterjee R, Giri AK, Mandal C, Chaudhuri K (2010) Arsenic-induced cell proliferation is associated with enhanced ROS generation, Erk signaling and Cyclin A expression. Toxicol Lett 198:263–271
Corelle E, Nebout M, Bekri S, Gauthier N, Hofman P, Poujeol P, Fénichel P, Mograbi B (2006) Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity. Cancer Res 66:6861–6869
Crighton D, O’Prey J, Bell HS, Ryan KM (2007) p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. Cell Death Differ 14:1071–1079
Csordas A, Kreutmayer S, Ploner C, Braun PR, Karlas A, Backovic A, Wick G, Bernhard D (2011) Cigarette smoke extract induces prolonged endoplasmic reticulum stress and autophagic cell death in human umbilical vein endothelial cells. Cardiovasc Res 92:141–148. https://doi.org/10.1093/cvr/cvr165
Das DN, Naik PP, Nayak A, Panda PK, Mukhopadhyay S, Sinha N, Bhutia SK (2016) Bacopa monnieri-induced protective autophagy inhibits benzo[a]pyrene-mediated apoptosis. Phytother Res 30:1794–1801
Das DN, Panda PK, Naik PP, Mukhopadhyay S, Sinha N, Bhutia SK (2017a) Phytotherapeutic approach: a new hope for polycyclic aromatic hydrocarbons induced cellular disorders, autophagic and apoptotic cell death. Toxicol Mech Methods 27:1–17
Das DN, Panda PK, Sinha N, Mukhopadhyay S, Naik PP, Bhutia SK (2017b) DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced p53-mediated apoptosis through activation of cytochrome P450/aryl hydrocarbon receptor. Environ Toxicol Pharmacol 55:175–185
Das DN, Naik PP, Mukhopadhyay S, Panda PK, Sinha N, Meher BR, Bhutia SK (2017c) Elimination of dysfunctional mitochondria through mitophagy suppresses benzo[a]pyrene-induced apoptosis. Free Radic Biol Med 112:452–463
De Abrew KN, Thomas-Virnig CL, Rasmussen CA, Bolterstein EA, Schlosser SJ, Allen-Hoffmann BL (2014) TCDD induces dermal accumulation of keratinocyte-derived matrix metalloproteinase-10 in an organotypic model of human skin. Toxicol Appl Pharmacol 276:171–178
de Oliveira Alves N, Vessoni AT, Quinet A, Fortunato RS, Kajitani GS, Peixoto MS, Hacon SS, Artaxo P, Saldiva P, Menck CFM, Batistuzzo de Medeiros SR (2017) Biomass burning in the Amazon region causes DNA damage and cell death in human lung cells. Sci Rep 7:10937
Deng X, Zhang F, Rui W, Long F, Wang L, Feng Z, Chen D, Ding W (2013) PM2.5-induced oxidative stress triggers autophagy in human lung epithelial A549 cells. Toxicol In Vitro 27:1762–1770
Deng X, Zhang F, Wang L, Rui W, Long F, Zhao Y, Chen D, Ding W (2014) Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells. Apoptosis 19:1099–1112
Di Gioacchino M, Petrarca C, Perrone A, Farina M, Sabbioni E, Hartung T, Martino S, Esposito DL, Lotti LV, Mariani-Costantini R (2008) Autophagy as an ultrastructural marker of heavy metal toxicity in human cord blood hematopoietic stem cells. Sci Total Environ 392:50–58
Dietrich C, Kaina B (2010) The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth. Carcinogenesis 31:1319–1328
Dino P, D’Anna C, Sangiorgi C, Di Sano C, Di Vincenzo S, Ferraro M, Pace E (2019) Cigarette smoke extract modulates E-Cadherin, Claudin-1 and miR-21 and promotescancer invasiveness in human colorectal adenocarcinoma cells. Toxicol Lett 317:102–109
Divekar SD, Li HH, Parodi DA, Ghafouri TB, Chen R, Cyrus K, Foxworth AE, Fornace AJ, Byrne C, Martin MB (2019) Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. https://doi.org/10.1093/carcin/bgz176
Duan Z, Zhao J, Fan X, Tang C, Liang L, Nie X, Liu J, Wu Q, Xu G (2014a) The PERK-eIF2α signaling pathway is involved in TCDD-induced ER stress in PC12 cells. Neurotoxicology 44:149–159
Duan J, Yu Y, Yu Y, Li WJ, Geng W, Jiang L, Li Q, Zhou X, Sun Z (2014b) Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway. Int J Nanomedicine 9:5131–5141
El-Demerdash FM, Tousson EM, Kurzepa J, Habib SL (2018) Xenobiotics, oxidative stress, and antioxidants. Oxidative Med Cell Longev 2018:9758951
Fan T, Chen Y, He Z, Wang Q, Yang X, Ren Z, Zhang S (2019) Inhibition of ROS/NUPR1-dependent autophagy antagonises repeated cadmium exposure-induced oral squamous cell carcinoma cell migration and invasion. Toxicol Lett 314:142–152
Fiorito F, Ciarcia R, Granato GE, Marfe G, Iovane V, Florio S, De Martino L, Pagnini U (2011) 2,3,7,8-tetrachlorodibenzo-p-dioxin induced autophagy in a bovine kidney cell line. Toxicology 290:258–270
Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, Gonzalez-Baron M (2004) PI3K/Akt signalling pathway and cancer. Cancer Treat Rev 30:193–204
Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT (2017) The PI3K pathway in human disease. Cell 170:605–635
Fujishiro H, Liu Y, Ahmadi B, Templeton DM (2018) Protective effect of cadmium-induced autophagy in rat renal mesangial cells. Arch Toxicol 92:619–631
Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, Penninger J, Piacentini M, Rubinsztein DC, Simon HU, Simonsen A, Thorburn AM, Velasco G, Ryan KM, Kroemer G (2015) Autophagy in malignant transformation and cancer progression. EMBO J 34:856–880
Gannon AM, Stämpfli MR, Foster WG (2013) Cigarette smoke exposure elicits increased autophagy and dysregulation of mitochondrial dynamics in murine granulosa cells. Biol Reprod 88:63
Gelboin HV (1980) Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. Physiol Rev 60:1107–1166
Gu X, Han M, Du Y, Wu Y, Xu Y, Zhou X, Ye D, Wang HL (2019) Pb disrupts autophagic flux through inhibiting the formation and activity of lysosomes in neural cells. Toxicol In Vitro 55:43–50
Guo L, Li L, Wang W, Pan Z, Zhou Q, Wu Z (2012) Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible factor-1α expression in human non-small cell lung cancer cells. Biochim Biophys Acta 822:852–861
Guo J, Xu Y, Ji W, Song L, Dai C, Zhan L (2015) Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling. Toxicol Lett 234:201–210
Guo C, Yang M, Jing L et al (2016) Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling. Int J Nanomedicine 11:5257–5276
Gyongyosi A, Szoke K, Fenyvesi F, Fejes Z, Debreceni IB, Nagy B Jr, Tosaki A, Lekli I (2019) Inhibited autophagy may contribute to heme toxicity in cardiomyoblast cells. Biochem Biophys Res Commun 511:732–738
Hamanaka RB, Chandel NS (2010) Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci 35:505–513
Hankinson O (2016) The role of AHR-inducible cytochrome P450s in metabolism of polyunsaturated fatty acids. Drug Metab Rev 48:342–350
Hansson MJ, Månsson R, Morota S, Uchino H, Kallur T, Sumi T, Ishii N, Shimazu M, Keep MF, Jegorov A, Elmér E (2008) Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition. Free Radic Biol Med 45:284–294
He B, Chen Q, Zhou D, Wang L, Liu Z (2019) Role of reciprocal interaction between autophagy and endoplasmic reticulum stress in apoptosis of human bronchial epithelial cells induced by cigarette smoke extract. IUBMB Life 71:66–80
Hoffmann RF, Zarrintan S, Brandenburg SM, Kol A, de Bruin HG, Jafari S, Dijk F, Kalicharan D, Kelders M, Gosker HR, Ten Hacken NH, van der Want JJ, van Oosterhout AJ, Heijink IH (2013) Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells. Respir Res 14:97
Houghton AM (2013) Mechanistic links between COPD and lung cancer. Nat Rev Cancer 13:233–245
Huang H, Zhu J, Li Y, Zhang L, Gu J, Xie Q, Jin H, Che X, Li J, Huang C, Chen LC, Lyu J, Gao J, Huang C (2016) Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells. Autophagy 12:1687–1703
Hwang HJ, Dornbos P, Steidemann M, Dunivin TK, Rizzo M, LaPres JJ (2016) Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome. Toxicol Appl Pharmacol 304:121–132
Jahangirnejad R, Goudarzi M, Kalantari H, Najafzadeh H, Rezaei M (2020) Subcellular organelle toxicity caused by arsenic nanoparticles in isolated rat hepatocytes. Int J Occup Environ Med 11:41–52
Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN (2014) Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol 7:60–72
Jancova P, Anzenbacher P, Anzenbacherova E (2010) Phase II drug metabolizing enzymes. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 154:103–116
Jang HS, Lee JE, Myung CH, Park JI, Jo CS, Hwang JS (2019) Particulate matter-induced aryl hydrocarbon receptor regulates autophagy in keratinocytes. Biomol Ther (Seoul) 11:570–576
Jeong JK, Gurunathan S, Kang MH et al (2016) Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells. Sci Rep 6:21688
Ji K, Xing C, Jiang F, Wang X, Guo H, Nan J, Qian L, Yang P, Lin J, Li M, Li J, Liao L, Tang J (2013) Benzo[a]pyrene induces oxidative stress and endothelial progenitor cell dysfunction via the activation of the NF-κB pathway. Int J Mol Med 31:922–930
Ji X, Xu B, Yao M, Mao Z, Zhang Y, Xu G, Tang Q, Wang X, Xia Y (2016) Graphene oxide quantum dots disrupt autophagic flux by inhibiting lysosome activity in GC-2 and TM4 cell lines. Toxicology 374:10–17
Jiang Y, Zhou X, Chen X, Yang G, Wang Q, Rao K, Xiong W, Yuan J (2011) Benzo(a)pyrene-induced mitochondrial dysfunction and cell death in p53-null Hep3B cells. Mutat Res 726:75–83
Jiang Y, Chen X, Yang G, Wang Q, Wang J, Xiong W, Yuan J (2013) BaP-induced DNA damage initiated p53-independent necroptosis via the mitochondrial pathway involving Bax and Bcl-2. Hum Exp Toxicol 32:1245–1257
Jimma Y, Jimma K, Yachi M, Hakata S, Habano W, Ozawa S, Terashima J (2019) Aryl hydrocarbon receptor mediates cell proliferation enhanced by benzo[a]pyrene in human lung cancer 3D spheroids. Cancer Investig 37:367–375
Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, Xie M, Zhang Q, McMichael JF, Wyczalkowski MA, Leiserson MDM, Miller CA, Welch JS, Walter MJ, Wendl MC, Ley TJ, Wilson RK, Raphae J, Ding L (2013) Mutational landscape and significance across 12 major cancer types. Nature 502:333–339
Kang YT, Hsu WC, Wu CH, Hsin IL, Wu PR, Yeh KT, Ko JL (2017) Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells. Oncotarget 8:105536–105552
Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S (2005) Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene 24:980–991
Kim SM, Lee HM, Hwang KA, Choi KC (2017) Benzo(a)pyrene induced cell cycle arrest and apoptosis in human choriocarcinoma cancer cells through reactive oxygen species-induced endoplasmic reticulum-stress pathway. Food Chem Toxicol 107:339–348
Kim HR, Kang SY, Kim HO, Park CW, Chung BY (2020) Role of aryl hydrocarbon receptor activation and autophagy in psoriasis-related inflammation. Int J Mol Sci 21:E2195
Kimmelman AC, White E (2017) Autophagy and tumor metabolism. Cell Metab 25:1037–1043
Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, Blagosklonny MV, El-Deiry WS, Golstein P, Green DR, Hengartner M, Knight RA, Kumar S, Lipton SA, Malorni W, Nuñez G, Peter ME, Tschopp J, Yuan J, Piacentini M, Zhivotovsky B, Melino G (2009) Classification of cell death: recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ 16:3–11
Kudo I, Hosaka M, Haga A, Tsuji N, Nagata Y, Okada H, Fukuda K, Kakizaki Y, Okamoto T, Grave E, Itoh H (2018) The regulation mechanisms of AhR by molecular chaperone complex. J Biochem 163:223–232
Kvitko K, Bandinelli E, Henriques JA, Heuser VD, Rohr P, da Silva FR, Schneider NB, Fernandes S, Ancines C, da Silva J (2012) Susceptibility to DNA damage in workers occupationally exposed to pesticides, to tannery chemicals and to coal dust during mining. Genet Mol Biol 35:1060–1068
Lafleur MA, Stevens JL, Lawrence JW (2013) Xenobiotic perturbation of ER stress and the unfolded protein response. Toxicol Pathol 41:235–262
Le Y, Wang Y, Zhou L, Xiong J, Tian J, Yang X, Gai X, Sun Y (2020) Cigarette smoke-induced HMGB1 translocation and release contribute to migration and NF-κB activation through inducing autophagy in lung macrophages. J Cell Mol Med 24:1319–1331
Lee J, Jeong H, Park EJ, Hwang JW, Bae EK, Ahn JK, Ahn KS, Koh EM, Cha HS (2013) A role for benzo[a]pyrene and slug in invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis: a potential molecular link between smoking and radiographic progression. Joint Bone Spine 80:621–625
Levine B (2007) Cell biology: autophagy and cancer. Nature 446:745–747
Levine B, Klionsky DJ (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6:463–477
Li Q, Gao C, Deng H, Song Q, Yuan L (2019a) Benzo[a]pyrene induces pyroptotic and autophagic death through inhibiting PI3K/Akt signaling pathway in HL-7702 human normal liver cells. J Toxicol Sci 44:121–131
Li Z, Li Q, Lv W, Jiang L, Geng C, Yao X, Shi X, Liu Y, Cao J (2019b) The interaction of Atg4B and Bcl-2 plays an important role in Cd-induced crosstalk between apoptosis and autophagy through disassociation of Bcl-2-Beclin1 in A549 cells. Free Radic Biol Med 130:76–591
Li R, Yang L, Jiang N, Wang F, Zhang P, Zhou R, Zhang J (2020) Activated macrophages are crucial during acute PM2.5 exposure-induced angiogenesis in lung cancer. Oncol Lett 19:725–734
Liao TL, Chen SC, Tzeng CR, Kao SH (2014) TCDD induces the hypoxia-inducible factor (HIF)-1α regulatory pathway in human trophoblastic JAR cells. Int J Mol Sci 15:17733–17750
Lin T, Mak NK, Yang MS (2008) MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation. Toxicology 247:145–153
Lin YF, Chiu IJ, Cheng FY et al (2016) The role of hypoxia-inducible factor-1 alpha in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo. Part Fibre Toxicol 13:52
Lin H, Zhang X, Feng N, Wang R, Zhang W, Deng X, Wang Y, Yu X, Ye X, Li L, Qian Y, Yu H, Qian B (2018) LncRNA LCPAT1 mediates smoking/particulate matter 2.5-induced cell autophagy and epithelial-mesenchymal transition in lung cancer cells via RCC2. Cell Physiol Biochem 47:1244–1258
Liu F, Inageda K, Nishitai G, Matsuoka M (2006) Cadmium induces the expression of Grp78, an endoplasmic reticulum molecular chaperone, in LLC-PK1 renal epithelial cells. Environ Health Perspect 114:859–864
Liu T, Wu B, Wang Y, He H, Lin Z, Tan J, Yang L, Kamp DW, Zhou X, Tang J, Huang H, Zhang L, Bin L, Liu G (2015a) Particulate matter 2.5 induces autophagy via inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin kinase signaling pathway in human bronchial epithelial cells. Mol Med Rep 12:1914–1922
Liu Y, Wu YM, Yu Y, Cao CS, Zhang JH, Li K, Zhang PY (2015b) Curcumin and resveratrol in combination modulate drug-metabolizing enzymes as well as antioxidant indices during lung carcinogenesis in mice. Hum Exp Toxicol 34:620–627
Liu XJ, Wang LN, Zhang ZH, Liang C, Li Y, Luo JS, Peng CJ, Zhang XL, Ke ZY, Huang LB, Tang YL, Luo XQ (2020) Arsenic trioxide induces autophagic degradation of the FLT3-ITD mutated protein in FLT3-ITD acute myeloid leukemia cells. J Cancer 11:3476–3482
Luo YH, Wu SB, Wei YH, Chen YC, Tsai MH, Ho CC, Lin SY, Yang CS, Lin P (2013) Cadmium-based quantum dot induced autophagy formation for cell survival via oxidative stress. Chem Res Toxicol 26:662–673
Luo C, Li Y, Yang L et al (2014) Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts. Int J Nanomedicine 9:4763–4772
Mannino DM, Aguayo SM, Petty TL, Redd SC (2003) Low lung function and incident lung cancer in the United States: data From the First National Health and Nutrition Examination Survey follow-up. Arch Intern Med 163:1475–1480
Mao J, Ma L, Shen Y, Zhu K, Zhang R, Xi W, Ruan Z, Luo C, Chen Z, Xi X, Chen S (2018) Arsenic circumvents the gefitinib resistance by binding to P62 and mediating autophagic degradation of EGFR in non-small cell lung cancer. Cell Death Dis 9:963
Marchi S, Bittremieux M, Missiroli S, Morganti C, Patergnani S, Sbano L, Rimessi A, Kerkhofs M, Parys JB, Bultynck G, Giorgi C, Pinton P (2017) Endoplasmic reticulum-mitochondria communication through Ca(2+) signaling: the importance of mitochondria-associated membranes (MAMs). Adv Exp Med Biol 997:49–67
Martini-Stoica H, Xu Y, Ballabio A, Zheng H (2016) The autophagy-lysosomal pathway in neurodegeneration: a TFEB perspective. Trends Neurosci 39:221–234
Mathew R, White E (2011) Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Curr Opin Genet Dev 21:113–119
Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, Chen G, Jin S, White E (2007) Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 21:1367–1381
McAuliffe PF, Meric-Bernstam F, Mills GB, Gonzalez-Angulo AM (2010) Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis. Clin Breast Cancer 3:S59–S65
Memmott RM, Dennis PA (2010) The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis. Clin Cancer Res 16:4–10
Messner B, Türkcan A, Ploner C, Laufer G, Bernhard D (2016) Cadmium overkill: autophagy, apoptosis and necrosis signalling in endothelial cells exposed to cadmium. Cell Mol Life Sci 73:1699–1713
Micale RT, La Maestra S, Di Pietro A, Visalli G, Baluce B, Balansky R, Steele VE, De Flora S (2013) Oxidative stress in the lung of mice exposed to cigarette smoke either early in life or in adulthood. Arch Toxicol 87:915–918
Mizumura K, Cloonan SM, Nakahira K, Bhashyam AR, Cervo M, Kitada T, Glass K, Owen CA, Mahmood A, Washko GR, Hashimoto S, Ryter SW, Choi AM (2014) Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. J Clin Invest 124:3987–4003
Moreau K, Luo S, Rubinsztein DC (2010) Cytoprotective roles for autophagy. Curr Opin Cell Biol 22:206–211
Naveenkumar C, Raghunandakumar S, Asokkumar S, Binuclara J, Rajan B, Premkumar T, Devaki T (2014) Mitigating role of baicalein on lysosomal enzymes and xenobiotic metabolizing enzyme status during lung carcinogenesis of Swiss albino mice induced by benzo(a)pyrene. Fundam Clin Pharmacol 28:310–322
Nebert DW, Dalton TP (2006) The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nat Rev Cancer 6:947–960
Ng Kee Kwong F, Nicholson AG, Harrison CL, Hansbro PM, Adcock IM, Chung KF (2017) Is mitochondrial dysfunction a driving mechanism linking COPD to nonsmall cell lung carcinoma? Eur Respir Rev 26:170040
Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, Shiosaka S, Hammarback JA, Urano F, Imaizumi K (2006) Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 26:9220–9231
Ogier-Denis E, Pattingre S, El Benna J et al (2000) Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. J Biol Chem 275:39090–39095
Pal D, Suman S, Kolluru V, Sears S, Das TP, Alatassi H, Ankem MK, Freedman JH, Damodaran C (2017) Inhibition of autophagy prevents cadmium-induced prostate carcinogenesis. Br J Cancer 117:56–64
Palanisamy K, Krishnaswamy R, Paramasivan P, Chih-Yang H, Vishwanadha VP (2015) Eicosapentaenoic acid prevents TCDD-induced oxidative stress and inflammatory response by modulating MAP kinases and redox-sensitive transcription factors. Br J Pharmacol 172:4726–4740
Panda PK, Mukhopadhyay S, Das DN, Sinha N, Naik PP, Bhutia SK (2015) Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics. Semin Cell Dev Biol 39:43–55
Park SY, Lee SM, Ye SK, Yoon SH, Chung MH, Choi J (2006) Benzo[a]pyrene-induced DNA damage and p53 modulation in human hepatoma HepG2 cells for the identification of potential biomarkers for PAH monitoring and risk assessment. Toxicol Lett 167:27–33
Park EJ, Umh HN, Kim SW et al (2014) ERK pathway is activated in bare-FeNPs-induced autophagy. Arch Toxicol 88:323–336
Patterson AD, Gonzalez FJ, Perdew GH, Peters JM (2018) Molecular regulation of carcinogenesis: friend and foe. Toxicol Sci 165:277–283
Pelissier-Rota MA, Pelosi L, Meresse P, Jacquier-Sarlin MR (2015) Nicotine-induced cellular stresses and autophagy in human cancer colon cells: a supportive effect on cell homeostasis via up-regulation of Cox-2 and PGE(2) production. Int J Biochem Cell Biol 65:239–256
Peng H, Zhao XH, Bi TT, Yuan XY, Guo JB, Peng SQ (2017) PM (2.5) obtained from urban areas in Beijing induces apoptosis by activating nuclear factor-kappa B. Mil Med Res 4:27
Person RJ, Tokar EJ, Xu Y, Orihuela R, Ngalame NN, Waalkes MP (2013) Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells. Toxicol Appl Pharmacol 273:281–288
Petrache Voicu SN, Dinu D, Sima C et al (2015) Silica nanoparticles induce oxidative stress and autophagy but not apoptosis in the MRC-5 cell line. Int J Mol Sci 16:29398–29416
Piao MJ, Ahn MJ, Kang KA, Ryu YS, Hyun YJ, Shilnikova K, Zhen AX, Jeong JW, Choi YH, Kang HK, Koh YS, Hyun JW (2018) Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis. Arch Toxicol 92:2077–2091
Purdue MP, Gold L, Jarvholm B, Alavanja MC, Ward MH, Vermeulen R (2007) Impaired lung function and lung cancer incidence in a cohort of Swedish construction workers. Thorax 62:51–56
Qin H, Gao F, Wang Y, Huang B, Peng L, Mo B, Wang C (2019) Nur77 promotes cigarette smoke-induced autophagic cell death by increasing the dissociation of Bcl2 from Beclin-1. Int J Mol Med 44:25–36
Rainey NE, Saric A, Leberre A, Dewailly E, Slomianny C, Vial G, Zeliger HI, Petit PX (2017) Synergistic cellular effects including mitochondrial destabilization, autophagy and apoptosis following low-level exposure to a mixture of lipophilic persistent organic pollutants. Sci Rep 7:4728
Ratovitski EA (2011) ΔNp63α/IRF6 interplay activates NOS2 transcription and induces autophagy upon tobacco exposure. Arch Biochem Biophys 506:208–215
Reyes H, Reisz-Porszasz S, Hankinson O (1992) Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 256:1193–1195
Rinna A, Magdolenova Z, Hudecova A et al (2015) Effect of silver nanoparticles on mitogen-activated protein kinases activation: role of reactive oxygen species and implication in DNA damage. Mutagenesis 30:59–66
Rizzuto R, Bernardi P, Pozzan T (2000) Mitochondria as all-round players of the calcium game. J Physiol 529(Pt 1):37–47
Roy R, Singh SK, Chauhan LK, Das M, Tripathi A, Dwivedi PD (2014) Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition. Toxicol Lett 227:29–40
Ryter SW, Rosas IO, Owen CA, Martinez FJ, Choi ME, Lee CG, Elias JA, Choi AMK (2018) Mitochondrial dysfunction as a pathogenic mediator of chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Ann Am Thorac Soc 15:S266–S272
Salem AF, Al-Zoubi MS, Whitaker-Menezes D, Martinez-Outschoorn UE, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Galbiati F, Bevilacqua G, Sotgia F, Lisanti MP (2013) Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment. Cell Cycle 12:818–825
Shen J, Xu L, Owonikoko TK, Sun SY, Khuri FR, Curran WJ, Deng X (2012) NNK promotes migration and invasion of lung cancer cells through activation of c-Src/PKCι/FAK loop. Cancer Lett 318:106–113
Smith DM, Patel S, Raffoul F, Haller E, Mills GB, Nanjundan M (2010) Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells. Cell Death Differ 17:1867–1881
Song D, Chen Y, Wang B, Li D, Xu C, Huang H, Huang S, Liu R (2019) Bisphenol A inhibits autophagosome-lysosome fusion and lipid droplet degradation. Ecotoxicol Environ Saf 183:109492
Soto AM, Sonnenschein C (2010) Environmental causes of cancer: endocrine disruptors as carcinogens. Nat Rev Endocrinol 6:363–370
Su R, Jin X, Zhang W, Li Z, Liu X, Ren J (2017) Particulate matter exposure induces the autophagy of macrophages via oxidative stress mediated PI3K/AKT/mTOR pathway. Chemosphere 167:444–453
Sui L, Zhang RH, Zhang P, Yun KL, Zhang HC, Liu L, Hu MX (2015) Lead toxicity induces autophagy to protect against cell death through mTORC1 pathway in cardiofibroblasts. Biosci Rep 35:e00186
Tai H, Wang Z, Gong H, Han X, Zhou J, Wang X, Wei X, Ding Y, Huang N, Qin J, Zhang J, Wang S, Gao F, Chrzanowska-Lightowlers ZM, Xiang R, Xiao H (2017) Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence. Autophagy 13:99–113
Tam LM, Price NE, Wang Y (2020) Molecular mechanisms of arsenic-induced disruption of DNA repair. Chem Res Toxicol 33:709–726
Tang MS, Wu XR, Lee HW, Xia Y, Deng FM, Moreira AL, Chen LC, Huang WC, Lepor H (2019) Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice. Proc Natl Acad Sci U S A 116:21727–21731
Tsai MJ, Wang TN, Lin YS, Kuo PL, Hsu YL, Huang MS (2015) Aryl hydrocarbon receptor agonists upregulate VEGF secretion from bronchial epithelial cells. J Mol Med (Berl) 93:1257–1269
Tsay JJ, Tchou-Wong KM, Greenberg AK, Pass H, Rom WN (2013) Aryl hydrocarbon receptor and lung cancer. Anticancer Res 33:1247–1256
Ueng TH, Chang YL, Tsai YY, Su JL, Chan PK, Shih JY, Lee YC, Ma YC, Kuo ML (2010) Potential roles of fibroblast growth factor-9 in the benzo(a)pyrene-induced invasion in vitro and the metastasis of human lung adenocarcinoma. Arch Toxicol 84:651–660
Valvezan AJ, Turner M, Belaid A, Lam HC, Miller SK, McNamara MC, Baglini C, Housden BE, Perrimon N, Kwiatkowski DJ, Asara JM, Henske EP, Manning BD (2017) mTORC1 couples nucleotide synthesis to nucleotide demand resulting in a targetable metabolic vulnerability. Cancer Cell 32:624–638.e5
Villano CM, Murphy KA, Akintobi A, White LA (2006) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces matrix metalloproteinase (MMP) expression and invasion in A2058 melanoma cells. Toxicol Appl Pharmacol 210:212–224
Volkov MS, Kobliakov VA (2011) Activation of transcription factor NF-kappaB by carcinogenic polycyclic aromatic hydrocarbons. Tsitologiia 53:418–422
Wang BY, Wu SY, Tang SC, Lai CH, Ou CC, Wu MF, Hsiao YM, Ko JL (2015) Benzo[a]pyrene-induced cell cycle progression occurs via ERK-induced Chk1 pathway activation in human lung cancer cells. Mutat Res 773:1–8
Wang J, Yu Y, Lu K et al (2017a) Silica nanoparticles induce autophagy dysfunction via lysosomal impairment and inhibition of autophagosome degradation in hepatocytes. Int J Nanomedicine 12:809–825
Wang G, Zhang T, Sun W, Wang H, Yin F, Wang Z, Zuo D, Sun M, Zhou Z, Lin B, Xu J, Hua Y, Li H, Cai Z (2017b) Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma. Free Radic Biol Med 106:24–37
Wang Y, Mandal AK, Son YO, Pratheeshkumar P, Wise JTF, Wang L, Zhang Z, Shi X, Chen Z (2018) Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane. Toxicol Appl Pharmacol 353:23–30
Wang Y, Shi L, Li J, Li L, Wang H, Yang H (2019a) Involvement of p38 MAPK pathway in benzo(a)pyrene-induced human hepatoma cell migration and invasion. Environ Sci Pollut Res Int 26:35838–35845
Wang L, Kumar M, Deng Q, Wang X, Liu M, Gong Z, Zhang S, Ma X, Xu-Monette ZY, Xiao M, Yi Q, Young KH, Ramos KS, Li Y (2019b) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces peripheral blood abnormalities and plasma cell neoplasms resembling multiple myeloma in mice. Cancer Lett 440–441:135–144
Wang K, Fang Zhang Q, Zhang Y, Yang Zhao Z (2019c) S-Allylcysteine as an inhibitor of benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells via inhibiting activation of nuclear factor-kappa. Nat Prod Commun 14:12
Watabe Y, Nazuka N, Tezuka M, Shimba S (2010) Aryl hydrocarbon receptor functions as a potent coactivator of E2F1-dependent transcription activity. Biol Pharm Bull 33:389–397
Wei X, Qi Y, Zhang X, Qiu Q, Gu X, Tao C, Huang D, Zhang Y (2014) Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway. Toxicol Mech Methods 24:504–511
Wu H, Lin J, Liu P et al (2015) Is the autophagy a friend or foe in the silver nanoparticles associated radiotherapy for glioma? Biomaterials 62:47–57
Wu JC, Tsai ML, Lai CS, Lo CY, Ho CT, Wang YJ, Pan MH (2018) Polymethoxyflavones prevent benzo[a]pyrene/dextran sodium sulfate-induced colorectal carcinogenesis through modulating xenobiotic metabolism and ameliorate autophagic defect in ICR mice. Int J Cancer 142:1689–1701
Wu X, Sun R, Wang H, Yang B, Wang F, Xu H, Chen S, Zhao R, Pi J, Xu Y (2019) Enhanced p62-NRF2 feedback loop due to impaired autophagic flux contributes to arsenic-induced malignant transformation of human keratinocytes. Oxidative Med Cell Longev 2019:1038932
Wu YF, Li ZY, Dong LL, Li WJ, Wu YP, Wang J, Chen HP, Liu HW, Li M, Jin CL, Huang HQ, Ying SM, Li W, Shen HH, Chen ZH (2020a) Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation. Autophagy 16:435–450
Wu Y, Niu Y, Leng J, Xu J, Chen H, Li H, Wang L, Hu J, Xia D, Wu Y (2020b) Benzo(a)pyrene regulated A549 cell migration, invasion and epithelial-mesenchymal transition by up-regulating long non-coding RNA linc00673. Toxicol Lett 320:37–45
Xu C, Bailly-Maitre B, Reed JC (2005) Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115:2656–2664
Xu XC, Wu YF, Zhou JS, Chen HP, Wang Y, Li ZY, Zhao Y, Shen HH, Chen ZH (2017) Autophagy inhibitors suppress environmental particulate matter-induced airway inflammation. Toxicology 280:206–212
Xu Z, Ding W, Deng X (2019) PM(2.5), fine particulate matter: a novel player in the epithelial-mesenchymal transition? Front Physiol 10:1404
Xueyi L, Shenyuan H, Chunxia G, Deng H, Liu Y, Li C, Yuan L, Luo Y (2019) Isoorientin attenuates benzo[a]pyrene-induced liver injury by inhibiting autophagy and pyroptosis in vitro and vivo. Food Agric Immunol 1:841–861
Yang H, Zhang H, Pan T, Wang H, Wang Y (2018) Benzo(a)pyrene promotes migration, invasion and metastasis of lung adenocarcinoma cells by upregulating TGIF. Toxicol Lett 294:11–19
Yang X, Ku T, Sun Z, Liu QS, Yin N, Zhou Q, Faiola F, Liao C, Jiang G (2019) Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo. Toxicol Lett 312:139–147
Yecies JL, Manning BD (2011) Transcriptional control of cellular metabolism by mTOR signaling. Cancer Res 71:2815–2820
Yim WW, Mizushima N (2020) Lysosome biology in autophagy. Cell Discov 6:6
Yin L, Yu X (2018) Arsenic-induced apoptosis in the p53-proficient and p53-deficient cells through differential modulation of NFkB pathway. Food Chem Toxicol 118:849–860
Yu KN, Yoon TJ, Minai-Tehrani A, Kim JE, Park SJ, Jeong MS, Ha SW, Lee JK, Kim JS, Cho MH (2013) Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation. Toxicol In Vitro 27:1187–1195
Zahedi A, Phandthong R, Chaili A, Leung S, Omaiye E, Talbot P (2019) Mitochondrial stress response in neural stem cells exposed to electronic cigarettes. iScience 16:250–269
Zhai H, Pan T, Yang H, Wang H, Wang Y (2019) Cadmium induces A549 cell migration and invasion by activating ERK. Exp Ther Med 18:1793–1799
Zhang Q, Tang X, Zhang ZF, Velikina R, Shi S, Le AD (2007) Nicotine induces hypoxia-inducible factor-1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways. Clin Cancer Res 13:4686–4694
Zhang W, Liu N, Wang X, Jin X, Du H, Peng G, Xue J (2015) Benzo(a)pyrene-7,8-diol-9,10-epoxide induced p53-independent necrosis via the mitochondria-associated pathway involving Bax and Bak activation. Hum Exp Toxicol 34:179–190
Zhang L, Xia Q, Zhou Y, Li J (2019a) Endoplasmic reticulum stress and autophagy contribute to cadmium-induced cytotoxicity in retinal pigment epithelial cells. Toxicol Lett 311:105–113
Zhang M, Shi R, Zhang Y, Shan H, Zhang Q, Yang X, Li Y, Zhang J (2019b) Nix/BNIP3L-dependent mitophagy accounts for airway epithelial cell injury induced by cigarette smoke. J Cell Physiol 234:14210–14220
Zhao J, Tang C, Nie X, Xi H, Jiang S, Jiang J, Liu S, Liu X, Liang L, Wan C, Yang J (2016) Autophagy potentially protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin induced apoptosis in SH-SY5Y cells. Environ Toxicol 31:1068–1079
Zilfou JT, Lowe SW (2009) Tumor suppressive functions of p53. Cold Spring Harb Perspect Biol 1:a001883
Zimta AA, Schitcu V, Gurzau E, Stavaru C, Manda G, Szedlacsek S, Berindan-Neagoe I (2019) Biological and molecular modifications induced by cadmium and arsenic during breast and prostate cancer development. Environ Res 178:108700
Zou H, Wang T, Yuan J, Sun J, Yuan Y, Gu J, Liu X, Bian J, Liu Z (2020) Cadmium-induced cytotoxicity in mouse liver cells is associated with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes. Toxicol Lett 321:32–43
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Das, D.N., Panda, P.K. (2020). Role of Xenobiotic in Autophagy Inflection in Cell Death and Carcinogenesis. In: Bhutia, S.K. (eds) Autophagy in tumor and tumor microenvironment . Springer, Singapore. https://doi.org/10.1007/978-981-15-6930-2_1
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