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Cholesteryl Ester Transfer Protein and Lipid Metabolism and Cardiovascular Diseases

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Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1276))

Abstract

In this chapter, we present the major advances in CETP research since the detection, isolation, and characterization of its activity in the plasma of humans and several species. Since CETP is a major modulator of HDL plasma levels, the clinical importance of CETP activity was recognized very early. We describe the participation of CETP in reverse cholesterol transport, conflicting results in animal and human genetic studies, possible new functions of CETP, and the results of the main clinical trials on CETP inhibition. Despite major setbacks in clinical trials, the hypothesis that CETP inhibitors are anti-atherogenic in humans is still being tested.

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Acknowledgments

We thank our co-authors on the original studies reviewed here, as well as other groups for their original contributions to the field. HCFO and HFR research was supported by Fundação de Amparo a Pesquisa do Estado de São Paulo (Fapesp grants #2017/17728-8, # 2015/17555-0 and # 2013/07607-8) and Conselho Nacional de Desenvolvimento CientÚfico e Tecnológico (CNPq grants #300937/2018-0)

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  1. Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil

    Helena C. F. Oliveira & Helena F. Raposo

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  1. Helena C. F. Oliveira
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  2. Helena F. Raposo
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Correspondence to Helena C. F. Oliveira .

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  1. Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA

    Xian-Cheng Jiang

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Oliveira, H.C.F., Raposo, H.F. (2020). Cholesteryl Ester Transfer Protein and Lipid Metabolism and Cardiovascular Diseases. In: Jiang, XC. (eds) Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease. Advances in Experimental Medicine and Biology, vol 1276. Springer, Singapore. https://doi.org/10.1007/978-981-15-6082-8_2

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