Abstract
Drug discovery using plants is an emerging task for leads identification. The drug discovery process involves selection of plant material to phytochemical analysis, characterization, and pharmacological investigation followed by detailed preclinical investigation to clinical trials. Up to 1996, approximately 80% of medicinal products were either directly originated from naturally occurring compounds or motivated by a natural product. 1881 new drugs were approved between the years 1981 and 2019, out of them approximately 23.5% were natural products or semi-synthetic derivatives of natural products, and approximately 25% were either natural product mimic or contained pharmacophore from a natural product. Drug discovery requires the development of efficient and feasible leads, which advance from screening a hit to a drug candidate through structural elucidation identification by GC-MS, NMR, IR, HPLC, and HPTLC. The development of new expertise has modernized the evaluation of natural products in new drug discovery.
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Abbreviations
- CE:
-
Capillary electrophoresis
- CML:
-
Chronic myelogenous leukemia
- CPT:
-
Camptothecin
- GBF:
-
German Research Centre for Biotechnology
- GC:
-
Gas chromatography
- HKI:
-
Hans Knöll Institute, Jena, Germany
- HPLC:
-
High performance liquid chromatography
- HPTLC:
-
High performance thin layer chromatography
- HTS:
-
High throughput screening
- IL:
-
Ionic liquid
- LC:
-
Liquid chromatography
- MS:
-
Mass spectrometry
- MS-MS:
-
Tandem mass spectrometry
- NMR:
-
Nuclear magnetic resonance spectroscopy
- NP:
-
Natural product
- PCF:
-
Plant cell fermentation
- PDA:
-
Photo diode array detector
- Pdbu:
-
Phorboldibutyrate
- Rt:
-
Retention time
- SAR:
-
Structure-activity relationships
- SFE:
-
Supercritical fluid extraction
- SPE:
-
Serum protein electrophoresis
- TLC:
-
Thin layer chromatography
- UV-Vis:
-
Ultraviolet-visible
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The author with BG and BS acknowledge IIT (BHU), Varanasi, for providing teaching assistantship.
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Goel, B., Sahu, B., Jain, S.K. (2020). Plant-Derived Drug Discovery: Introduction to Recent Approaches. In: Singh, B. (eds) Botanical Leads for Drug Discovery. Springer, Singapore. https://doi.org/10.1007/978-981-15-5917-4_1
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