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An Intergenic Variant rs4779584 Between SCG5 and GREM1 Contributes to the Increased Risk of Colorectal Cancer: A Meta-Analysis

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Novel therapeutic approaches for gastrointestinal malignancies

Part of the book series: Diagnostics and Therapeutic Advances in GI Malignancies ((DTAGIM))

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Abstract

Colorectal cancer (CRC) is very common malignancy all over the world. Adoption of Western diet (red meat and high fat foods) in many countries has increased the incidence of colorectal cancer. There are genetic factors as well as environmental factors contributed to the etiology of CRC. Current meta-analysis is envisioned to investigate the association between rs4779584 variant and risk of CRC. PubMed, Google Scholar, and Embase were used for the collection of publication to retrieve data. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association between rs4779584 variant and risk of CRC. To determine heterogeneity, Cochrane Q test and I2 statistic were employed. Subgroup analysis and sensitivity analysis were performed to assess between-study heterogeneity. Publication bias was determined through Funnel plots and Egger’s test. Total 14 publications with 26 different studies comprising 25,469 CRC cases and 32,745 controls were finally considered for meta-analysis. Overall, a positive association of rs4779584 polymorphism with CRC risk was found in all genetic models (allelic model: OR = 1.13; 95% CI 1.08–1.18; p = <0.001; I2: 53%; dominant model: OR = 1.14; 95% CI 1.08–1.21; p < 0.001; I2: 41%; and recessive model: OR = 1.19; 95% CI 1.09–1.30; p < 0.001; I2: 44%). The level of heterogeneity was significant for all ethnic groups. No significant publication bias was found in this meta-analysis. Based on this meta-analysis, it can be confirmed that the rs4779584 polymorphism and CRC risk shares a positive correlation in patients where T allele was a susceptible factor.

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Abbreviations

BMP:

Bone morphogenetic protein

CI:

Confidence interval

CRC:

Colorectal cancer

FEM:

Fixed-effects model

FMN 1:

Formin 1

GREM1:

Gremlin 1

GWAS:

Genome-wide association studies

IBD:

Inflammatory bowel disease

OR:

Odds ratio

REM:

Random-effects model

SCG5:

Secretogranin V

SNP:

Single nucleotide polymorphism

TGF-β:

Transforming growth factor β

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Authors and Affiliations

  1. Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, CG, India

    Samrat Rakshit & L. V. K. S. Bhaskar

Authors
  1. Samrat Rakshit
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  2. L. V. K. S. Bhaskar
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Editor information

Editors and Affiliations

  1. Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Dr. B.R. Ambedkar University, Srikakulam, Andhra Pradesh, India

    Sujatha Peela

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Rakshit, S., Bhaskar, L.V.K.S. (2020). An Intergenic Variant rs4779584 Between SCG5 and GREM1 Contributes to the Increased Risk of Colorectal Cancer: A Meta-Analysis. In: Nagaraju, G.P., Peela, S. (eds) Novel therapeutic approaches for gastrointestinal malignancies. Diagnostics and Therapeutic Advances in GI Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-15-5471-1_10

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