Abstract
Toxicity of benzo(a)pyrene [B(a)P] is frequently intervened by oxidative metabolism to reactive intermediates that interrelate with macromolecules prompting changes in the structure and function of target cells. Hence, the human body is continually under oxidative stress merging from exogenous sources mainly through tobacco smoke and cellular endogenous roots which involve mitochondria. Where such oxidative stress surpasses the limit of the body’s oxidation-reduction system, gene mutations may result, or intracellular signal transduction and transcription factors might be influenced legitimately or through antioxidants, leading to carcinogenesis. Increasing evidence indicates that oncogenic incitement has expanded metabolic action, and malfunction of mitochondria is the main reason for increased intrinsic reactive oxygen species (ROS) stress in cancer cells. In cancer cells, the enormous production of endogenous ROS is the major source of DNA-damaging agents, which leads to genetic instability, and as a consequence, the cancer cells become drug resistant. Mitochondrial respiratory chain (electron transport complexes) is the major source of ROS generation in the cell which causes damages in the mitochondrial DNA. ROS-interceded damage appears to be a mechanism for augmenting ROS stress in cancer cells. This present chapter discusses the role of oxidative stress derived from B(a)P metabolism relating to lung cancer.
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Chandrashekar, N. (2021). Benzo(a)pyrene-Induced Oxidative Stress During Lung Cancer and Treatment with Baicalein. In: Chakraborti, S., Ray, B.K., Roychowdhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-4501-6_183-1
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