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Stem Cell Therapy for Parkinson’s Disease

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Stem Cell-based Therapy for Neurodegenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1266))

Abstract

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases caused by specific degeneration and loss of dopamine neurons in substantia nigra of the midbrain. PD is clinically characterized by motor dysfunctions and non-motor symptoms. Even though the dopamine replacement can improve the motor symptoms of PD, it cannot stop the neural degeneration and disease progression. Electrical deep brain stimulation (DBS) to the specific brain areas can improve the symptoms, but it eventually loses the effectiveness. Stem cell transplantation provides an exciting potential for the treatment of PD. Current available cell sources include neural stem cells (NSCs) from fetal brain tissues, human embryonic stem cells (hESCs) isolated from blastocyst, and induced pluripotent stem cells (iPSCs) reprogrammed from the somatic cells such as the fibroblasts and blood cells. Here, we summarize the research advance in experimental and clinical studies to transplant these cells into animal models and clinical patients, and specifically highlight the studies to use hESCs /iPSCs-derived dopaminergic precursor cells and dopamine neurons for the treatment of PD, at last propose future challenges for developing clinical-grade dopaminergic cells for treating the PD.

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Acknowledgment

This work was supported by National Natural Science Foundation of China (NSFC 81571241), Department of Science and Technology of Shandong Province, China (2017GSF18104), Science and Technology Innovation Committee of Shenzhen Municipality, China (JCYJ201803051642562) and Basic Research Fund from Natural Science Foundation of Shandong Province, China (ZR2019ZD39). We also thank Wei Wang, Jing Duan, Xianjie Lu, Hao Song, Nan Zhang, and Yanming Liu in our lab for technically editing the references and preparing figures of the manuscript.

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  1. The Institute for Translational Medicine, Affiliated Hospital, Shandong University, Jinan, Shandong, China

    Fabin Han

  2. The Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/Liaocheng People’s Hospital, Liaocheng, Shandong, China

    Fabin Han

  3. Shenzhen Research Institute, Shandong University, Shenzhen, Guangdong, China

    Fabin Han

  4. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

    Baoyang Hu

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  1. Fabin Han
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Correspondence to Fabin Han .

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  1. The Second Affiliated Hospital, Shandong University, Jinan, Shandong, China

    Fabin Han

  2. School of Medicine, University of California at San Diego, La Jolla, CA, USA

    Pengzhe (Paul) Lu

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Han, F., Hu, B. (2020). Stem Cell Therapy for Parkinson’s Disease. In: Han, F., Lu, P.(. (eds) Stem Cell-based Therapy for Neurodegenerative Diseases. Advances in Experimental Medicine and Biology, vol 1266. Springer, Singapore. https://doi.org/10.1007/978-981-15-4370-8_3

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