Abstract
Chronic Obstructive Pulmonary Disease (COPD) is a classical chronic respiratory disease with the pathological changes involving the bronchi and alveoli. Many of the risk factors of COPD can induce autophagy in different kinds of cells in lung tissue including alveolar epithelial cells, broncho epithelial cells, and fibroblasts. Over-activation of autophagy may cause emphysema by inducing autophagic cell death. However, the bronchitis and fibrosis may be mainly caused by autophagic flux blocking. Thus, understanding the role of autophagy in the pathogenesis of COPD is important for the anti-COPD drug development.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Alexandra CR, Sarah AK, Augustine MKC et al (2018) Autophagy and inflammation in chronic respiratory disease. Autophagy 14(2):221–232
Bi R, Dai Y, Ma Z et al (2019) Endothelial cell autophagy in chronic intermittent hypoxia is impaired by miRNA-30a-mediated translational control of Beclin-1. J Cell Biochem 120(3):4214–4224
Chen Z-H, Lam HC, Jin Y, Kim H-P, Cao J, Lee S-J, Ifedigbo E, Parameswaran H, Ryter SW, Choi AMK (2010) Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema. Proc Nat Acad Sci 107(44):18880–18885
Guo Y, Gosker HR, Schols AM et al (2013) Autophagy in locomotor muscles of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 188(11):1313–1320
Haspel JA, Choi AM (2011) Autophagy: a core cellular process with emerging links to pulmonary disease. Am J Respir Crit Care Med 184(11):1237–1246
Li ZY, Wu YF, Xu XC et al (2017) Autophagy as a double-edged sword in pulmonary epithelial injury: a review and perspective. Am J Physiol Lung Cell Mol Physiol 313(2):L207–L217
Morse D, Rosas IO (2014) Tobacco smoke-induced lung fibrosis and emphysema. Ann Rev Physiol 76:493–513
Zhu XM, Wang Q, Xing WW et al (2018) PM2.5 induces autophagy-mediated cell death via NOS2 signaling in human bronchial epithelium cells. Int J Biol Sci 14(5):557–564
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Science Press and Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Lv, X., Li, K., Hu, Z. (2020). Chronic Obstructive Pulmonary Disease and Autophagy. In: Le, W. (eds) Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, vol 1207. Springer, Singapore. https://doi.org/10.1007/978-981-15-4272-5_39
Download citation
DOI: https://doi.org/10.1007/978-981-15-4272-5_39
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-4271-8
Online ISBN: 978-981-15-4272-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)